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anti-Acvr2a antibody :: Mouse anti-Human Activin Receptor Type IIA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6002407 anti-Acvr2a antibody
Unit / Price
100 Tests  /  $740 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin Receptor Type IIA (Acvr2a), Monoclonal Antibody

 Also Known As   

Activin Receptor Type IIA (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2) (APC)

 Product Synonym Names    Anti -Activin Receptor Type IIA (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2) (APC)
 Product Gene Name   

anti-Acvr2a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_005102.3 (38113728..38197531). Location: 3q12
 3D Structure    ModBase 3D Structure for P38444
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 Clonality    Monoclonal
 Isotype    IgG2A
 Clone Number    12K5
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Activin RIIA.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
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 Immunogen    Recombinant corresponding to human Activin Receptor IIA extracellular domain expressed in SF-21 cells.
 Emission    660-670nm
 Excitation    620-650nm
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 Preparation and Storage    May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
 Other Notes    Small volumes of anti-Acvr2a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Acvr2a antibody

   Activin isoforms and other members of the TGF-B superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActRI(A), ActRIB, ActRII(A) and ActRIIB, have been cloned from mammals. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% aa sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.
 Product Categories/Family for anti-Acvr2a antibody    Antibodies; Abs to Activin Receptors
 Applications Tested/Suitable for anti-Acvr2a antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-Acvr2a antibody    Suitable for use in Flow Cytometry.
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NCBI/Uniprot data below describe general gene information for Acvr2a. It may not necessarily be applicable to this product.
 NCBI GI #    73853745
 NCBI GeneID    29263
 NCBI Accession #    NP_113759.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031571.2 [Other Products]
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 UniProt Primary Accession #    P38444 [Other Products]
 UniProt Related Accession #    P38444 [Other Products]
 Molecular Weight    57,893 Da [Similar Products]
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 NCBI Official Full Name    activin receptor type-2A
 NCBI Official Synonym Full Names    activin A receptor, type IIA
 NCBI Official Symbol    Acvr2a [Similar Products]
 NCBI Official Synonym Symbols   
Acvr2; rActR-II
[Similar Products]
 NCBI Protein Information    activin receptor type-2A; ACTR-IIA; activin receptor IIA; type II activin receptor; activin receptor type IIA
 UniProt Protein Name    Activin receptor type-2A
 UniProt Synonym Protein Names   
Activin receptor type IIA
 Protein Family    Activin receptor
 UniProt Gene Name    Acvr2a [Similar Products]
 UniProt Synonym Gene Names    Actrii; Acvr2; ACTR-IIA [Similar Products]
 UniProt Entry Name    AVR2A_RAT
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 NCBI Summary for Acvr2a    acts as a receptor for activin A and inhibin A [RGD, Feb 2006]
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 UniProt Comments for Acvr2a    ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.

Protein type: EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Protein kinase, TKL; TKL group; STKR family; Type2 subfamily

Cellular Component: cell surface; cytoplasm; integral to membrane; activin receptor complex; receptor complex

Molecular Function: protein serine/threonine kinase activity; activin receptor activity; protein self-association; metal ion binding; growth factor binding; activin binding; coreceptor activity; activin receptor activity, type II; ATP binding; transmembrane receptor protein serine/threonine kinase activity; PDZ domain binding; receptor signaling protein serine/threonine kinase activity

Biological Process: embryonic skeletal development; positive regulation of erythrocyte differentiation; male gonad development; regulation of BMP signaling pathway; activin receptor signaling pathway; regulation of signal transduction; Sertoli cell proliferation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; BMP signaling pathway; response to organic substance; anterior/posterior pattern formation; positive regulation of osteoblast differentiation; positive regulation of activin receptor signaling pathway; spermatogenesis; mesoderm development; positive regulation of follicle-stimulating hormone secretion; sperm ejaculation; regulation of nitric-oxide synthase activity; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; penile erection
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 Research Articles on Acvr2a    1. In a rat model of HF, we demonstrated a concerted induction of the gene expression of activin betaA and activin receptors IA, IB, IIA, and IIB after myocardial infarction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Acvr2a antibodyPathways associated with anti-Acvr2a antibody
 Reference Product  PubMed Publications
 Bmpr2 antibody  >8 publications with Acvr2a and Bmpr2
 Acvr1 antibody  >7 publications with Acvr2a and Acvr1
 Bmpr1a antibody  >6 publications with Acvr2a and Bmpr1a
 Bmp2 antibody  >4 publications with Acvr2a and Bmp2
 Smad2 antibody  >4 publications with Acvr2a and Smad2
 Acvr1b antibody  >1 publications with Acvr2a and Acvr1b
 Smad4 antibody  >1 publications with Acvr2a and Smad4
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-Acvr2a antibodyOrgans/Tissues associated with anti-Acvr2a antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with Acvr2a and Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with Acvr2a and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >3 publications with Acvr2a and Congenital Abnormalities
 Nervous System Diseases Antibodies  >2 publications with Acvr2a and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >2 publications with Acvr2a and Craniofacial Abnormalities
 Disease Models, Animal Antibodies  >2 publications with Acvr2a and Disease Models, Animal
 Nervous System Malformations Antibodies  >1 publications with Acvr2a and Nervous System Malformations
 Heart Defects, Congenital Antibodies  >1 publications with Acvr2a and Heart Defects, Congenital
 Fibrosis Antibodies  >1 publications with Acvr2a and Fibrosis
 Breast Neoplasms Antibodies  >1 publications with Acvr2a and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with Acvr2a and Muscle
 Brain Antibodies  >1 publications with Acvr2a and Brain
 Connective Tissue Antibodies  >1 publications with Acvr2a and Connective Tissue
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