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anti-ACVR2B antibody :: Mouse anti-Human Activin Receptor Type IIB Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS605715 anti-ACVR2B antibody
Unit / Price
0.1 mg  /  $645 +1 FREE 8GB USB
0.5 mg  /  $1,320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin Receptor Type IIB (ACVR2B), Monoclonal Antibody

 Also Known As   

Activin Receptor Type IIB (RIIB)

 Product Synonym Names    Anti -Activin Receptor Type IIB (RIIB)
 Product Gene Name   

anti-ACVR2B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (38495790..38534633). Location: 3p22
 OMIM    602730
 3D Structure    ModBase 3D Structure for Q13705
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9H21
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes recombinant human Activin RIIB. Shows ~5% crossreactivity with recombinant human Activin RIIA.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS.
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 Immunogen    Recombinant protein corresponding to the extracellular domain of human Activin RIIB, expressed in NSO cells.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ACVR2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACVR2B antibody

   Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta) family members, including Activin, Nodal, BMP-7, GDF-1, GDF-3, Myostatin (GDF-8), and GDF-11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.
 Product Categories/Family for anti-ACVR2B antibody    Antibodies; Abs to Activin Receptors
 Applications Tested/Suitable for anti-ACVR2B antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-ACVR2B antibody    Suitable for use in Direct ELISA and Western Blot.
Dilution: Direct ELISA: 0.5-1.0ug/ml. The detection limit for recombinant human Activin RIIB is ~2ng/well.
Western Blot: 1-2ug/ml. The detection limit for recombinant human Activin RIIB is ~20ng/lane under reducing and non-reducing conditions.
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NCBI/Uniprot data below describe general gene information for ACVR2B. It may not necessarily be applicable to this product.
 NCBI GI #    5731735
 NCBI GeneID    93
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 UniProt Primary Accession #    Q13705 [Other Products]
 UniProt Secondary Accession #    Q4VAV0 [Other Products]
 UniProt Related Accession #    Q13705; Q4VAU9; Q59FL1; Q71UM3 [Other Products]
 Molecular Weight    57,724 Da [Similar Products]
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 NCBI Official Full Name    activin receptor type IIB
 NCBI Official Synonym Full Names    activin A receptor, type IIB
 NCBI Official Symbol    ACVR2B [Similar Products]
 NCBI Official Synonym Symbols   
HTX4; ACTRIIB; ActR-IIB; MGC116908
[Similar Products]
 NCBI Protein Information    activin receptor type-2B; OTTHUMP00000161965
 UniProt Protein Name    Activin receptor type-2B
 UniProt Synonym Protein Names   
Activin receptor type IIB
 Protein Family    Activin receptor
 UniProt Gene Name    ACVR2B [Similar Products]
 UniProt Entry Name    AVR2B_HUMAN
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 NCBI Summary for ACVR2B    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]
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 UniProt Comments for ACVR2B    ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: Membrane protein, integral; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Kinase, protein; Protein kinase, TKL; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; metal ion binding; growth factor binding; activin binding; protein serine/threonine/tyrosine kinase activity; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; embryonic foregut morphogenesis; lymphangiogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; pancreas development; response to glucose stimulus; mesoderm development; kidney development; gastrulation with mouth forming second; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; organ growth; positive regulation of osteoblast differentiation; insulin secretion; skeletal morphogenesis; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development

Disease: Heterotaxy, Visceral, 4, Autosomal
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 Research Articles on ACVR2B    1. discussion of crystal structure of kinase domain of ActRIIB; structural analysis may be of help in developing selective inhibitors [REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACVR2B antibodyPathways associated with anti-ACVR2B antibody
 Reference Product  PubMed Publications
 BMP7 antibody  >5 publications with ACVR2B and BMP7
 BMP2 antibody  >5 publications with ACVR2B and BMP2
 MSTN antibody  >4 publications with ACVR2B and MSTN
 GDF11 antibody  >3 publications with ACVR2B and GDF11
 INHBA antibody  >1 publications with ACVR2B and INHBA
 ACVR1B antibody  >1 publications with ACVR2B and ACVR1B
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-ACVR2B antibodyOrgans/Tissues associated with anti-ACVR2B antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >9 publications with ACVR2B and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >4 publications with ACVR2B and Heart Defects, Congenital
 Craniofacial Abnormalities Antibodies  >2 publications with ACVR2B and Craniofacial Abnormalities
 Dextrocardia Antibodies  >2 publications with ACVR2B and Dextrocardia
 Lung Neoplasms Antibodies  >1 publications with ACVR2B and Lung Neoplasms
 Carcinoma Antibodies  >1 publications with ACVR2B and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with ACVR2B and Breast Neoplasms
 Hepatitis Antibodies  >1 publications with ACVR2B and Hepatitis
 Body Weight Changes Antibodies  >1 publications with ACVR2B and Body Weight Changes
 Atrophy Antibodies  >1 publications with ACVR2B and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >4 publications with ACVR2B and Ovary
 Heart Antibodies  >4 publications with ACVR2B and Heart
 Kidney Antibodies  >3 publications with ACVR2B and Kidney
 Lung Antibodies  >2 publications with ACVR2B and Lung
 Embryonic Tissue Antibodies  >2 publications with ACVR2B and Embryonic Tissue
 Ear Antibodies  >1 publications with ACVR2B and Ear
 Testis Antibodies  >1 publications with ACVR2B and Testis
 Stomach Antibodies  >1 publications with ACVR2B and Stomach
 Uncharacterized Tissue Antibodies  >1 publications with ACVR2B and Uncharacterized Tissue
 Mammary Gland Antibodies  >1 publications with ACVR2B and Mammary Gland
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