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anti-ADARB1 antibody :: Mouse anti-Human Adenosine Deaminase, RNA-specific, B1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS607515 anti-ADARB1 antibody
Unit / Price
0.05 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adenosine Deaminase, RNA-specific, B1 (ADARB1), Monoclonal Antibody

 Also Known As   

Adenosine Deaminase, RNA-specific, B1 (ADARB1, ADAR2, Double-stranded RNA-specific Editase 1, DRABA2, DRADA2, dsRNA Adenosine Deaminase, RNA Editase, RNA-editing Deaminase 1, RED1, RNA-editing Enzyme 1)

 Product Synonym Names    Anti -Adenosine Deaminase, RNA-specific, B1 (ADARB1, ADAR2, Double-stranded RNA-specific Editase 1, DRABA2, DRADA2, dsRNA Adenosine Deaminase, RNA Editase, RNA-editing Deaminase 1, RED1, RNA-editing Enzyme 1)
 Product Gene Name   

anti-ADARB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (46494493..46646478). Location: 21q22.3
 3D Structure    ModBase 3D Structure for O43263
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9j17
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human ADARB1.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
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 Immunogen    Partial recombinant sequence from the N-terminus of human ADARB1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ADARB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADARB1 antibody

   The mammalian Adenosine Deaminases Acting on RNA (ADAR) constitute a family of sequence-related proteins involved in pre-mRNA editing of nuclear transcripts through site-speci c adenosine modi cation. ADARs are not active on adenosine-mononucleotide and are only distantly related by sequence to adenosine and AMP deaminases involved in purine metabolism. The ADARs convert certain adenosine bases in an RNA transcript into inosines by removing an amino group involved in Watson-Crick base pairing. The ADARs recognize a double stranded RNA (dsRNA) structure in the transcript that is formed between the editing site complementary sequence (ECS), usually located in the downstream 3' intron of the transcript, and the sequence to be edited. The ADAR family of proteins consists of ADAR1 and ADAR2 which are expressed in many tissues and ADAR3 which is expressed in the brain. Regulated levels of ADAR1 expression are critical for embryonic erythropoiesis in the liver. Results show a requirement of regulated increase in the ADAR1 expression in liver at E12 and E13 stages. Failure to increase ADAR1 expression may result in underediting of the RNA of currently unknown target genes, which in turn affects proliferation and/or differentiation of erythrocytes. The absence of mature erythrocytes would lead to tissue hypoxia and the eventual death of the embryo. The best characterized target transcripts that undergo RNA editing by ADARs encode glutamate-sensitive ion channels that are expressed by neurons of the central nervous system.
 Product Categories/Family for anti-ADARB1 antibody    Antibodies; Abs to Enzymes
 Applications Tested/Suitable for anti-ADARB1 antibody   

Western Blot (WB), Gel Shift Assay (GS/EMSA)

 Application Notes for anti-ADARB1 antibody    Suitable for use in Western Blot and Dot Blot.
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NCBI/Uniprot data below describe general gene information for ADARB1. It may not necessarily be applicable to this product.
 NCBI GI #    119629766
 NCBI GeneID    104
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 UniProt Primary Accession #    O43263 [Other Products]
 UniProt Related Accession #    O43263; P78563; Q4AE77; Q4AE81; Q6P0M9; Q86XN4; Q8NFA1; Q8TCX7 [Other Products]
 Molecular Weight    75,970 Da [Similar Products]
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 NCBI Official Full Name    adenosine deaminase, RNA-specific, B1 (RED1 homolog rat), isoform CRA_e
 NCBI Official Synonym Full Names    adenosine deaminase, RNA-specific, B1
 NCBI Official Symbol    ADARB1 [Similar Products]
 NCBI Official Synonym Symbols   
RED1; ADAR2; DRABA2; DRADA2
[Similar Products]
 NCBI Protein Information    double-stranded RNA-specific editase 1; RNA editase; RED1 homolog; OTTHUMP00000115339; OTTHUMP00000115340; OTTHUMP00000115341; OTTHUMP00000115342; OTTHUMP00000174981; OTTHUMP00000214128; RNA-editing enzyme 1; RNA editing deaminase 1; RNA-editing deaminase 1; dsRNA adenosine deaminase; human dsRNA adenosine deaminase DRADA2; adenosine deaminase, RNA-specific, B1 (RED1 homolog rat); adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)
 UniProt Protein Name    RNA editing deaminase 1
 Protein Family    Double-stranded RNA-specific editase
 UniProt Gene Name    hRED1 [Similar Products]
 UniProt Entry Name    O43263_HUMAN
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 NCBI Summary for ADARB1    This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq]
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 Research Articles on ADARB1    1. The authors found that, analogously to ADAR1, ADAR2 enhances the release of progeny virions by an editing-dependent mechanism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ADARB1 antibodyDiseases associated with anti-ADARB1 antibody
 Products by Pathway  Pathway Diagram
 C6 Deamination Of Adenosine Pathway antibodies  C6 Deamination Of Adenosine Pathway Diagram
 Formation Of Editosomes By ADAR Proteins Pathway antibodies  Formation Of Editosomes By ADAR Proteins Pathway Diagram
 MRNA Editing Pathway antibodies  MRNA Editing Pathway Diagram
 MRNA Editing: A To I Conversion Pathway antibodies  MRNA Editing: A To I Conversion Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with ADARB1 and Neoplasms
 Mood Disorders Antibodies  >2 publications with ADARB1 and Mood Disorders
 Atherosclerosis Antibodies  >1 publications with ADARB1 and Atherosclerosis
 Obesity Antibodies  >1 publications with ADARB1 and Obesity
 Prostatic Neoplasms Antibodies  >1 publications with ADARB1 and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with ADARB1 and Cell Transformation, Neoplastic
 Hypertension Antibodies  >1 publications with ADARB1 and Hypertension
 Brain Diseases Antibodies  >1 publications with ADARB1 and Brain Diseases
 Lung Neoplasms Antibodies  >1 publications with ADARB1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with ADARB1 and Neoplasms, Experimental
Organs/Tissues associated with anti-ADARB1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with ADARB1 and Brain
 Prostate Antibodies  >2 publications with ADARB1 and Prostate
 Testis Antibodies  >1 publications with ADARB1 and Testis
 Kidney Antibodies  >1 publications with ADARB1 and Kidney
 Lung Antibodies  >1 publications with ADARB1 and Lung
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