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anti-ALPI antibody :: Mouse anti-Human, Cow Alkaline Phosphatase Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS438805 anti-ALPI antibody
Unit / Price
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 Product Name   

Alkaline Phosphatase (ALPI), Monoclonal Antibody

 Also Known As   

Alkaline Phosphatase (Intestinal) Mouse Monoclonal Antibody

 Product Synonym Names    Alkaline phosphatase, germ cell; Alkaline phosphatase, testicular and thymus; Akp2; Alkaline phosphatase intestinal; Alkaline phosphatase liver/bone/kidney; Alkaline phosphatase placental; Alkaline phosphatase placental like 2; Alkaline phosphatase, tissue-nonspecific; ALPG; ALPI; ALPL; ALPP; ALPPL; ALPPL2; AP TNAP; Germ cell alkaline phosphatase; HOPS; Intestinal alkaline phosphatase (IAP); Kasahara isozyme; Nagao isozyme; PLAP; PLAP like; Regan isozyme; Testicular and thymus alkaline phosphatase; Tissue non-specific alkaline phosphatase; Tissue nonspecific ALP (TNAP or TNSALP)
 Product Gene Name   

anti-ALPI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146300
 3D Structure    ModBase 3D Structure for P05186
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    SPM372
 Host    Mouse
 Species Reactivity    Human, Cow
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 Specificity    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface
 Immunogen    Bovine intestinal alkaline phosphatase
 Hu-Chromosome Location    2q37.1
 Positive Control    Intestine
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-ALPI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ALPI antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-ALPI antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Frozen) (0.5-1ug/ml for 30 minutes at RT)
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NCBI/Uniprot data below describe general gene information for ALPI. It may not necessarily be applicable to this product.
 NCBI GI #    116734717
 NCBI GeneID    249
 NCBI Accession #    NP_000469.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000478.5 [Other Products]
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 UniProt Primary Accession #    P05186 [Other Products]
 UniProt Secondary Accession #    O75090; Q2TAI7; Q59EJ7; Q5BKZ5; Q5VTG5; Q6NZI8; Q8WU32; A1A4E7; B2RMP8; B7Z387; B7Z4Y6 [Other Products]
 UniProt Related Accession #    P05186 [Other Products]
 Molecular Weight    55kDa
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 NCBI Official Full Name    alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein
 NCBI Official Synonym Full Names    alkaline phosphatase, liver/bone/kidney
 NCBI Official Symbol    ALPL [Similar Products]
 NCBI Official Synonym Symbols   
HOPS; TNAP; APTNAP; TNSALP; AP-TNAP
[Similar Products]
 NCBI Protein Information    alkaline phosphatase, tissue-nonspecific isozyme
 UniProt Protein Name    Alkaline phosphatase, tissue-nonspecific isozyme
 UniProt Synonym Protein Names   
Alkaline phosphatase liver/bone/kidney isozyme
 Protein Family    Alkaline phosphatase
 UniProt Gene Name    ALPL [Similar Products]
 UniProt Synonym Gene Names    AP-TNAP; TNSALP [Similar Products]
 UniProt Entry Name    PPBT_HUMAN
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 NCBI Summary for ALPI    This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
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 UniProt Comments for ALPI    ALPL: This isozyme may play a role in skeletal mineralization. Defects in ALPL are a cause of hypophosphatasia (HOPS). HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC). Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI). Belongs to the alkaline phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.1.3.1

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: membrane

Molecular Function: protein binding; pyrophosphatase activity

Biological Process: osteoblast differentiation; response to vitamin D; skeletal development

Disease: Hypophosphatasia, Adult; Hypophosphatasia, Childhood; Hypophosphatasia, Infantile
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Product References and Citations for anti-ALPI antibody

   Moss, D.W. 1987. Diagnostic aspects of alkaline phosphatase and its isoenzymes. Clin. Biochem. 20: 225-230. Griffin, C.A., et al. 1987. Human placental and intestinal alkaline phosphatase genes map to 2q34-q37. Am. J. Hum. Genet. 41: 1025-1034.
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 Research Articles on ALPI    1. The presence of TNAP increased the dynamics and decreased the ordering of model membranes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALPI antibodyPathways associated with anti-ALPI antibody
 Reference Product  PubMed Publications
 ENPP1 antibody  >12 publications with ALPI and ENPP1
 IBSP antibody  >10 publications with ALPI and IBSP
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-ALPI antibodyOrgans/Tissues associated with anti-ALPI antibody
 Disease Name  Pubmed Publications
 Seizures Antibodies  >20 publications with ALPI and Seizures
 Kidney Diseases Antibodies  >19 publications with ALPI and Kidney Diseases
 Cardiovascular Diseases Antibodies  >14 publications with ALPI and Cardiovascular Diseases
 Inflammation Antibodies  >13 publications with ALPI and Inflammation
 Pain Antibodies  >11 publications with ALPI and Pain
 Calcinosis Antibodies  >9 publications with ALPI and Calcinosis
 Liver Diseases Antibodies  >7 publications with ALPI and Liver Diseases
 Hypertrophy Antibodies  >6 publications with ALPI and Hypertrophy
 Necrosis Antibodies  >5 publications with ALPI and Necrosis
 Heart Diseases Antibodies  >5 publications with ALPI and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >229 publications with ALPI and Bone
 Blood Antibodies  >64 publications with ALPI and Blood
 Kidney Antibodies  >53 publications with ALPI and Kidney
 Connective Tissue Antibodies  >49 publications with ALPI and Connective Tissue
 Liver Antibodies  >43 publications with ALPI and Liver
 Mouth Antibodies  >22 publications with ALPI and Mouth
 Brain Antibodies  >19 publications with ALPI and Brain
 Adipose Tissue Antibodies  >17 publications with ALPI and Adipose Tissue
 Skin Antibodies  >11 publications with ALPI and Skin
 Heart Antibodies  >8 publications with ALPI and Heart
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