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anti-SERPINA1 antibody :: Mouse Alpha-1-antitrypsin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190009 anti-SERPINA1 antibody
Unit / Price
0.1 mg  /  $195 +1 FREE 8GB USB
0.5 mg  /  $330 +1 FREE 8GB USB
1 mg  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-1-antitrypsin (SERPINA1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Alpha-1-Antitrypsin Monoclonal Antibody

 Product Synonym Names    Anti-Alpha-1-antitrypsin; Alpha-1- Anti-Trypsin
 Product Gene Name   

anti-SERPINA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107400
 3D Structure    ModBase 3D Structure for P01009
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
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 Specificity    Anti-Alpha-1-antitrypsin [Human serum alpha-1-antitrypsin (4 clones). LP]
These antibodies specifically recognize alpha-1-antitrypsin.They do not crossreact with alpha-1-antichymotrypsin.
 Form/Format    1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4
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 Antigen    Purified human serum alpha- 1-antitrypsin.
 Activity    Ig mg/ml* :22.0
ELISA Titer**:1:204,800
(Note: * Determined by radial immunodiffusion for several lots of ascites.
**ELISA is an indirect assay against alpha-1-antitrypsin on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1)
 Stabilizer    None
 Preservatives    None. Available on request
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-SERPINA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SERPINA1 antibody    Enzyme and Enzyme Inhibitor Antibodies
 Applications Tested/Suitable for anti-SERPINA1 antibody   

Immunoassay

 Application Notes for anti-SERPINA1 antibody    These antibodies may be used in immunoassays to detect and quantitate alpha-1-antitrypsin. Other applications are under investigation.
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NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.
 NCBI GI #    151302818
 NCBI Accession #    CAJ15161.1 [Other Products]
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 UniProt Primary Accession #    P01009 [Other Products]
 UniProt Secondary Accession #    Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8 [Other Products]
 Molecular Weight    46,737 Da [Similar Products]
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 NCBI Official Full Name    alpha-1-antitrypsin
 UniProt Protein Name    Alpha-1-antitrypsin
 UniProt Synonym Protein Names   
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
 Protein Family    Alpha-1-antitrypsin
 UniProt Gene Name    SERPINA1 [Similar Products]
 UniProt Synonym Gene Names    AAT; PI [Similar Products]
 UniProt Entry Name    A1AT_HUMAN
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 NCBI Summary for SERPINA1    The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPINA1    SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding

Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; acute-phase response; response to methanol; response to hypoxia; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus

Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SERPINA1 antibodyPathways associated with anti-SERPINA1 antibody
 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with SERPINA1 and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Diseases associated with anti-SERPINA1 antibodyOrgans/Tissues associated with anti-SERPINA1 antibody
 Disease Name  Pubmed Publications
 alpha 1-Antitrypsin Deficiency Antibodies  >82 publications with SERPINA1 and alpha 1-Antitrypsin Deficiency
 Liver Diseases Antibodies  >72 publications with SERPINA1 and Liver Diseases
 Lung Diseases Antibodies  >72 publications with SERPINA1 and Lung Diseases
 Neoplasms Antibodies  >32 publications with SERPINA1 and Neoplasms
 Carcinoma Antibodies  >29 publications with SERPINA1 and Carcinoma
 Pulmonary Disease, Chronic Obstructive Antibodies  >25 publications with SERPINA1 and Pulmonary Disease, Chronic Obstructive
 Pulmonary Emphysema Antibodies  >23 publications with SERPINA1 and Pulmonary Emphysema
 Liver Cirrhosis Antibodies  >20 publications with SERPINA1 and Liver Cirrhosis
 Carcinoma, Hepatocellular Antibodies  >17 publications with SERPINA1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >17 publications with SERPINA1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >76 publications with SERPINA1 and Liver
 Blood Antibodies  >55 publications with SERPINA1 and Blood
 Lung Antibodies  >36 publications with SERPINA1 and Lung
 Skin Antibodies  >11 publications with SERPINA1 and Skin
 Kidney Antibodies  >9 publications with SERPINA1 and Kidney
 Vascular Antibodies  >7 publications with SERPINA1 and Vascular
 Pancreas Antibodies  >7 publications with SERPINA1 and Pancreas
 Intestine Antibodies  >6 publications with SERPINA1 and Intestine
 Bone Antibodies  >5 publications with SERPINA1 and Bone
 Heart Antibodies  >5 publications with SERPINA1 and Heart
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