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anti-AFP antibody :: anti-Human Alpha Fetoprotein (AFP) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS311666 anti-AFP antibody
Unit / Price
1 mg  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha Fetoprotein (AFP), Monoclonal Antibody

★Popular Item★
 Also Known As   

MAb to Alpha Fetoprotein (AFP)

 Product Synonym Names    MAb to AFP; Monoclonal Antibody to Human Alpha Fetoprotein
 Product Gene Name   

anti-AFP antibody

[Similar Products]
 Matching Pairs    Capture Antibody: Alpha Fetoprotein (AFP) Clone #131-12210 (TB-4B2-10) (MBS311665)
Detection Antibody: Alpha Fetoprotein (AFP) Clone #057-11301 (MBS311666)
 Matching Pairs    Capture Antibody: Alpha Fetoprotein (AFP) Clone #057-11301 (MBS311666)
Detection Antibody: Alpha Fetoprotein, (AFP) (MBS316744)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    chromosome: 4; Location: 4q11-q13
 OMIM    104150
 3D Structure    ModBase 3D Structure for P02771
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    057-11301
 Host    Host: Mouse
Source: Ascites
 Species Reactivity    Human
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 Specificity    Alpha Fetoprotein (AFP)
Human Alpha Fetoprotein (AFP)
 Purity/Purification    >90% pure (SDS-PAGE). Protein A chromatography
 Form/Format    Purified, Liquid
 Concentration    4.71 mg/ml (OD280nm, E^0.1% = 1.4) (lot specific)
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 Immunogen    Human AFP
 Affinity Constant    Not determined
 Buffer    10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
 Preservative    0.1% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short-term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-20 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-AFP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-AFP antibody    Monoclonal Antibodies for Cancer Research
 Applications Tested/Suitable for anti-AFP antibody   

ELISA; Immunoassay Antibody Pairs

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NCBI/Uniprot data below describe general gene information for AFP. It may not necessarily be applicable to this product.
 NCBI GI #    178236
 NCBI GeneID    174
 NCBI Accession #    AAB58754.1 [Other Products]
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 UniProt Primary Accession #    P02771 [Other Products]
 UniProt Secondary Accession #    B2RBU3 [Other Products]
 UniProt Related Accession #    P02771 [Other Products]
 Molecular Weight    68,678 Da [Similar Products]
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 NCBI Official Full Name    alpha-fetoprotein
 NCBI Official Synonym Full Names    alpha-fetoprotein
 NCBI Official Symbol    AFP [Similar Products]
 NCBI Official Synonym Symbols   
FETA; HPAFP; AFP
[Similar Products]
 NCBI Protein Information    alpha-fetoprotein
 UniProt Protein Name    Alpha-fetoprotein
 UniProt Synonym Protein Names   
Alpha-1-fetoprotein; Alpha-fetoglobulin
 Protein Family    Alpha-fetoprotein
 UniProt Gene Name    AFP [Similar Products]
 UniProt Synonym Gene Names    HPAFP [Similar Products]
 UniProt Entry Name    FETA_HUMAN
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 NCBI Summary for AFP    This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AFP    Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

Subunit structure: Dimeric and trimeric forms have been found in addition to the monomeric form.

Subcellular location: Secreted.

Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac.

Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.

Post-translational modification: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.Sulfated.

Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.
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 Research Articles on AFP    1. Assessment of Dkk3 and AFP may be useful in the diagnosis of hepatic tumors.
2. AFP promoter enhancer increased specific expression of the human sodium iodide symporter (hNIS) for targeted radioiodine therapy of hepatocellular carcinoma.
3. Alpha-fetoprotein was more sensitive than des-gamma carboxyprothrombin and lectin-bound alpha-fetoprotein in diagnosing early hepatocellular carcinoma.
4. Case Report: Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman.
5. The utility of the tumour markers carcinoembryonic antigen, cancer antigen 125, carbohydrate antigen 19-9, carbohydrate antigen 15-3, alpha-fetoprotein and human chorionic gonadotropin for the diagnosis solitary pulmonary nodules, was investigated.
6. Case Report: Alpha-fetoprotein expressing metastastic adenocarcinoma of the esophago-gastric junction responding favorably to capecitabine and oxaliplatin.
7. small amplitude undulations in AFP are associated with recurrence of germ cell neoplasm
8. Low Alphafetoprotein levels and increased CA 19-9 levels can be used as tumor markers in diagnosis of molar pregnancies in conjunction with clinical and sonographic findings and serum levels of human chorionic gonadotropin
9. Report des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma.
10. These data support the idea that ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer.
11. In hepatocellular carcinoma, pre-transplant AFP levels >400 ng/ml were associated with higher tumor recurrence.
12. Serum samples were investigated for carcinoembryonic antigen (CEA), CA125 and MUC1, alpha-foetoprotein, neuron-specific enolase and CA19.9.
13. In patients with hepatocellular carcinoma, a high frequency of AFP-specific CD8(+) T cells directed against different epitopes suggest that AFP has a strong and broad immunogenicity.
14. Molecular background of AFP in liver cancer cells as revealed by global RNA expression analysis is reported.
15. results suggest that AFP may positively regulate cell proliferation by enhancing the apoptosis resistance via dysfunction of the p53/Bax/cytochrome c/caspase-3 signaling pathway in AFP
16. Elevated alpha-fetoprotein is associated with primary central nervous system germ cell tumors.
17. Results indicate that the poor prognosis associated with high alpha-fetoprotein in hepatocellular carcinoma is due to high cell proliferation, high angiogenesis, and low apoptosis.
18. targeting of AFP with siRNA could be a potential therapeutic approach for hepatoma
19. substitution of aa 70 of HCV-1b core region is an important predictor of elevated AFP in non-HCC (hepatocellular carcinoma) patients.
20. The N-glycan structures of the Lens culinaris agglutinin (LCA)-reactive fraction of alpha-fetoprotein (AFP-L3), a tumor marker of hepatocellular carcinomas (HCC), were analyzed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AFP antibodyPathways associated with anti-AFP antibody
 Reference Product  PubMed Publications
 CCR5 antibody  >2 publications with AFP and CCR5
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
Diseases associated with anti-AFP antibodyOrgans/Tissues associated with anti-AFP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4487 publications with AFP and Neoplasms
 Carcinoma Antibodies  >3321 publications with AFP and Carcinoma
 Liver Diseases Antibodies  >3093 publications with AFP and Liver Diseases
 Liver Neoplasms Antibodies  >3033 publications with AFP and Liver Neoplasms
 Adenocarcinoma Antibodies  >2675 publications with AFP and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2652 publications with AFP and Carcinoma, Hepatocellular
 Hepatitis Antibodies  >872 publications with AFP and Hepatitis
 Liver Cirrhosis Antibodies  >837 publications with AFP and Liver Cirrhosis
 Congenital Abnormalities Antibodies  >730 publications with AFP and Congenital Abnormalities
 Male Urogenital Diseases Antibodies  >638 publications with AFP and Male Urogenital Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3740 publications with AFP and Liver
 Blood Antibodies  >3032 publications with AFP and Blood
 Vascular Antibodies  >395 publications with AFP and Vascular
 Lung Antibodies  >334 publications with AFP and Lung
 Brain Antibodies  >294 publications with AFP and Brain
 Embryonic Tissue Antibodies  >260 publications with AFP and Embryonic Tissue
 Muscle Antibodies  >163 publications with AFP and Muscle
 Kidney Antibodies  >161 publications with AFP and Kidney
 Placenta Antibodies  >153 publications with AFP and Placenta
 Heart Antibodies  >92 publications with AFP and Heart
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