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anti-ACY1 antibody :: Rat anti-Human Aminoacylase 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS606305 anti-ACY1 antibody
Unit / Price
0.1 mg  /  $630 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aminoacylase 1 (ACY1), Monoclonal Antibody

 Also Known As   

Aminoacylase 1 (ACY1)

 Product Synonym Names    Anti -Aminoacylase 1 (ACY1)
 Product Gene Name   

anti-ACY1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (52017563..52023218). Location: 3p21.1
 OMIM    104620
 3D Structure    ModBase 3D Structure for Q03154
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 Clonality    Monoclonal
 Isotype    IgG2B
 Clone Number    9L801
 Host    Rat
 Species Reactivity    Human
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 Specificity    Recognizes human Aminocyclase. Species sequence homology: chimpanzee (100%), canine (88%), mouse and rat (86%).
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS.
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 Immunogen    Purified, insect cell-derived, recombinant human aminoacylase (aa2-408).
 Hybridoma    Mouse myeloma cells with B cells obtained from a rat immunized with purified, insect cell-derived, recombinant human aminoacylase (aa2-408).
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ACY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACY1 antibody

   Aminoacylase (ACY1) is an intracellular soluble homodimeric zinc-binding enzyme. It is involved in the breakdown of acetylated amino acids generated during protein degradation by catalyzing the formation of free aliphatic amino acids from N-acetylated precursors. Mutations in the ACY1 gene might cause inborn metabolic disorders. The aa sequence of human ACY1 is 100%, 88% and 86% identical to that of chimpanzee, dog and mouse/rat.
 Product Categories/Family for anti-ACY1 antibody    Antibodies; Abs to Enzymes
 Applications Tested/Suitable for anti-ACY1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-ACY1 antibody    Suitable for use in ELISA, Western Blot, and Immunoprecipitation.
Dilution: ELISA: 0.5-1ug/ml
Immunoprecipitation: 25ug/ml
Western Blot: 1-2ug/ml
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NCBI/Uniprot data below describe general gene information for ACY1. It may not necessarily be applicable to this product.
 NCBI GI #    12804329
 NCBI GeneID    95
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 UniProt Primary Accession #    Q03154 [Other Products]
 UniProt Related Accession #    Q03154 [Other Products]
 Molecular Weight    45,885 Da [Similar Products]
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 NCBI Official Full Name    Aminoacylase 1
 NCBI Official Synonym Full Names    aminoacylase 1
 NCBI Official Symbol    ACY1 [Similar Products]
 NCBI Official Synonym Symbols   
ACY-1; ACY1D
[Similar Products]
 NCBI Protein Information    aminoacylase-1; OTTHUMP00000212459; OTTHUMP00000212462; OTTHUMP00000212463; OTTHUMP00000212464; OTTHUMP00000220363; N-acyl-L-amino-acid amidohydrolase
 UniProt Protein Name    Aminoacylase-1
 UniProt Synonym Protein Names   
N-acyl-L-amino-acid amidohydrolase
 Protein Family    Aminoacylase
 UniProt Gene Name    ACY1 [Similar Products]
 UniProt Entry Name    ACY1_HUMAN
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 NCBI Summary for ACY1    This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq]
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 UniProt Comments for ACY1    ACY1: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Belongs to the peptidase M20A family.

Protein type: Hydrolase; Amino Acid Metabolism - arginine and proline; EC 3.5.1.14

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cytosol

Molecular Function: metallopeptidase activity; metal ion binding; aminoacylase activity

Biological Process: amino acid metabolic process; xenobiotic metabolic process; proteolysis

Disease: Aminoacylase 1 Deficiency
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 Research Articles on ACY1    1. aminoacylase 1 proteins with the mutations p.Arg378Trp, p.Arg378Gln and p.Arg393His were also detected in Western blot analysis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ACY1 antibodyDiseases associated with anti-ACY1 antibody
 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Urea Cycle And Metabolism Of Amino Groups Pathway antibodies  Urea Cycle And Metabolism Of Amino Groups Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >9 publications with ACY1 and Carcinoma
 Neoplasms Antibodies  >7 publications with ACY1 and Neoplasms
 Carcinoma, Renal Cell Antibodies  >5 publications with ACY1 and Carcinoma, Renal Cell
 Adenocarcinoma Antibodies  >4 publications with ACY1 and Adenocarcinoma
 Kidney Diseases Antibodies  >3 publications with ACY1 and Kidney Diseases
 Urologic Neoplasms Antibodies  >3 publications with ACY1 and Urologic Neoplasms
 Carcinoma, Small Cell Antibodies  >3 publications with ACY1 and Carcinoma, Small Cell
 Kidney Neoplasms Antibodies  >3 publications with ACY1 and Kidney Neoplasms
 Lung Neoplasms Antibodies  >2 publications with ACY1 and Lung Neoplasms
 Aminoacylase 1 deficiency Antibodies  >2 publications with ACY1 and Aminoacylase 1 deficiency
Organs/Tissues associated with anti-ACY1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >7 publications with ACY1 and Lung
 Kidney Antibodies  >5 publications with ACY1 and Kidney
 Liver Antibodies  >3 publications with ACY1 and Liver
 Blood Antibodies  >2 publications with ACY1 and Blood
 Brain Antibodies  >2 publications with ACY1 and Brain
 Adrenal Gland Antibodies  >1 publications with ACY1 and Adrenal Gland
 Testis Antibodies  >1 publications with ACY1 and Testis
 Bone Antibodies  >1 publications with ACY1 and Bone
 Muscle Antibodies  >1 publications with ACY1 and Muscle
 Embryonic Tissue Antibodies  >1 publications with ACY1 and Embryonic Tissue
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