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anti-AREG antibody :: Mouse anti-Human Amphiregulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690007 anti-AREG antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Amphiregulin (AREG), Monoclonal Antibody

 Also Known As   

Mouse Anti-Human Amphiregulin

 Product Synonym Names    AREG; AR; SDGF; AREGB; CRDGF
 Product Gene Name   

anti-AREG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.12 (74445136..74455009). Location: 4q13.3
 OMIM    104640
 3D Structure    ModBase 3D Structure for P15514
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    (8K16)
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human Amphiregulin recombinant protein.
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-AREG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AREG antibody

   Amphiregulin (AR) is a member of the EGF family of cytokines which is comprised of at least ten proteins including EGF, TGFalpha, HBEGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or several EGF structural units in their extracellular domain. The soluble forms of these cytokines are released by proteolytic cleavage. Amphiregulin was originally isolated from the conditioned media of a PMAtreated MCF 7 human breast carcinoma cell line. The AR cDNA encodes a 252 amino acid (aa) residue transmembrane precursor. Multiple forms of native AR containing either 78 or 84 aa residues and both N- and O- linked oligosaccharides have been found. Amphiregulin mRNA expression can be detected in numerous carcinoma cell lines and the epithelial cells of various human tissues including colon, stomach, breast, ovary, kidney, etc. Human AR stimulates the proliferation of various human and mouse keratinocytes, mammary epithelial cells and some fibroblasts. AR is also a growth inhibitor for various tumor cell lines. In certain colon carcinoma cell lines, AR has been shown to be an autocrine growth factor. Amphiregulin can bind to the EGF receptor. It has been suggested that in certain cell types, AR bioactivity may be mediated through the EGF receptor. The 98 aa residue long form of recombinant amphiregulin has shown to be approximately 510 fold more active than the 78 aa residue form of recombinant AR in an in vitro proliferation assay using Balb/3T3 fibroblasts.
 Applications Tested/Suitable for anti-AREG antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for AREG. It may not necessarily be applicable to this product.
 NCBI GI #    4502199
 NCBI GeneID    374
 NCBI Accession #    NP_001648.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001657.2 [Other Products]
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 UniProt Primary Accession #    P15514 [Other Products]
 UniProt Secondary Accession #    Q5U026 [Other Products]
 UniProt Related Accession #    P15514 [Other Products]
 Molecular Weight    27,895 Da [Similar Products]
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 NCBI Official Full Name    amphiregulin preproprotein
 NCBI Official Synonym Full Names    amphiregulin
 NCBI Official Symbol    AREG [Similar Products]
 NCBI Official Synonym Symbols   
AR; SDGF; CRDGF
[Similar Products]
 NCBI Protein Information    amphiregulin; schwannoma-derived growth factor; colorectum cell-derived growth factor
 UniProt Protein Name    Amphiregulin
 UniProt Synonym Protein Names   
Colorectum cell-derived growth factor
 Protein Family    Amphiregulin
 UniProt Gene Name    AREG [Similar Products]
 UniProt Synonym Gene Names    SDGF; AR; CRDGF [Similar Products]
 UniProt Entry Name    AREG_HUMAN
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 NCBI Summary for AREG    The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AREG    Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Subunit structure: The immature precursor interacts with CNIH. Ref.12

Subcellular location: Membrane; Single-pass membrane protein.

Induction: By phorbol 12-myristate 13-acetate (PMA).

Miscellaneous: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.

Sequence similarities: Belongs to the amphiregulin family.Contains 1 EGF-like domain.
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 Research Articles on AREG    1. Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AREG antibodyPathways associated with anti-AREG antibody
 Reference Product  PubMed Publications
 EGFR antibody  >93 publications with AREG and EGFR
 PTGS2 antibody  >32 publications with AREG and PTGS2
 PGR antibody  >13 publications with AREG and PGR
 ERBB2 antibody  >13 publications with AREG and ERBB2
 ERBB3 antibody  >5 publications with AREG and ERBB3
 CYP11A1 antibody  >3 publications with AREG and CYP11A1
 ATF3 antibody  >2 publications with AREG and ATF3
 PTHLH antibody  >1 publications with AREG and PTHLH
 AKT1 antibody  >1 publications with AREG and AKT1
 Products by Pathway  Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with anti-AREG antibodyOrgans/Tissues associated with anti-AREG antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >85 publications with AREG and Neoplasms
 Breast Neoplasms Antibodies  >28 publications with AREG and Breast Neoplasms
 Necrosis Antibodies  >17 publications with AREG and Necrosis
 Inflammation Antibodies  >16 publications with AREG and Inflammation
 Adenocarcinoma Antibodies  >14 publications with AREG and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >12 publications with AREG and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >9 publications with AREG and Neoplasm Metastasis
 Liver Diseases Antibodies  >9 publications with AREG and Liver Diseases
 Liver Neoplasms Antibodies  >8 publications with AREG and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >8 publications with AREG and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >25 publications with AREG and Blood
 Mammary Gland Antibodies  >20 publications with AREG and Mammary Gland
 Lung Antibodies  >20 publications with AREG and Lung
 Skin Antibodies  >12 publications with AREG and Skin
 Liver Antibodies  >12 publications with AREG and Liver
 Vascular Antibodies  >8 publications with AREG and Vascular
 Prostate Antibodies  >8 publications with AREG and Prostate
 Intestine Antibodies  >6 publications with AREG and Intestine
 Bone Marrow Antibodies  >6 publications with AREG and Bone Marrow
 Placenta Antibodies  >5 publications with AREG and Placenta
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