NP_001112360.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
angiopoietin-2 isoform c
NCBI Official Synonym Full Names
angiopoietin 2
NCBI Official Synonym Symbols
NCBI Protein Information
angiopoietin-2
UniProt Protein Name
Angiopoietin-2
UniProt Synonym Gene Names
UniProt Entry Name
ANGP2_HUMAN
NCBI Summary for Ang-2
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for Ang-2
ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: cell projection; extracellular region; extracellular space; nucleus; plasma membrane
Molecular Function: metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding
Biological Process: angiogenesis; germ cell development; leukocyte migration; maternal process involved in pregnancy; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of positive chemotaxis; organ regeneration; positive regulation of angiogenesis; response to activity; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to organic cyclic substance; response to radiation; signal transduction; Tie receptor signaling pathway
Research Articles on Ang-2
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Products associated with anti-Ang-2 antibody
Pathways associated with anti-Ang-2 antibody
Diseases associated with anti-Ang-2 antibody
Organs/Tissues associated with anti-Ang-2 antibody
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