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anti-Ang-2 antibody :: Mouse Ang-2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS335758 anti-Ang-2 antibody
Unit / Price
0.5 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ang-2, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Human Ang-2 Azide Free

 Product Gene Name   

anti-Ang-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601922
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 Clonality    Monoclonal
 Isotype    IgG2b Kappa light chain
 Clone Number    B-C57
 Host    Mouse
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 Specificity    Recognises both natural and recombinant human Angiopoietin-2
 Form/Format    Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free. Azide free
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 Hybridoma    Myeloma X63/AG.8653 x Balb/c node cells
 Immunisation    Recombinant human Angiopoietin-2
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 Preparation and Storage    Store at 2-8 degree C for 12 months. For longer storage freeze aliquots.
 Other Notes    Small volumes of anti-Ang-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Ang-2 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for Ang-2. It may not necessarily be applicable to this product.
 NCBI GI #    169646754
 NCBI GeneID    285
 NCBI Accession #    NP_001112360.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001118888.1 [Other Products]
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 UniProt Secondary Accession #    Q9NRR7; Q9P2Y7; A0AV38; A8K205; B7ZLM7 [Other Products]
 UniProt Related Accession #    O15123 [Other Products]
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 NCBI Official Full Name    angiopoietin-2 isoform c
 NCBI Official Synonym Full Names    angiopoietin 2
 NCBI Official Symbol    ANGPT2 [Similar Products]
 NCBI Official Synonym Symbols   
ANG2; AGPT2
[Similar Products]
 NCBI Protein Information    angiopoietin-2
 UniProt Protein Name    Angiopoietin-2
 UniProt Gene Name    ANGPT2 [Similar Products]
 UniProt Synonym Gene Names    ANG-2 [Similar Products]
 UniProt Entry Name    ANGP2_HUMAN
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 NCBI Summary for Ang-2    The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Ang-2    ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: cell projection; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding

Biological Process: angiogenesis; germ cell development; leukocyte migration; maternal process involved in pregnancy; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of positive chemotaxis; organ regeneration; positive regulation of angiogenesis; response to activity; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to organic cyclic substance; response to radiation; signal transduction; Tie receptor signaling pathway
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 Research Articles on Ang-2    1. Serum and urine TNF-alpha, IL-18 and 8-OHdG levels increased significantly with the degree of albuminuria, and were positively correlated with increased Ang-2
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Ang-2 antibodyPathways associated with anti-Ang-2 antibody
 Reference Product  PubMed Publications
 ANGPT1 antibody  >360 publications with Ang-2 and ANGPT1
 VEGFA antibody  >184 publications with Ang-2 and VEGFA
 FGF2 antibody  >69 publications with Ang-2 and FGF2
 TEK antibody  >52 publications with Ang-2 and TEK
 TIE1 antibody  >42 publications with Ang-2 and TIE1
 KDR antibody  >39 publications with Ang-2 and KDR
 FLT1 antibody  >26 publications with Ang-2 and FLT1
 FOXO1 antibody  >10 publications with Ang-2 and FOXO1
 ETS1 antibody  >7 publications with Ang-2 and ETS1
 FLT4 antibody  >2 publications with Ang-2 and FLT4
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Tie2 Signaling Pathway antibodies  Tie2 Signaling Pathway Diagram
Diseases associated with anti-Ang-2 antibodyOrgans/Tissues associated with anti-Ang-2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >302 publications with Ang-2 and Cardiovascular Diseases
 Inflammation Antibodies  >278 publications with Ang-2 and Inflammation
 Disease Models, Animal Antibodies  >190 publications with Ang-2 and Disease Models, Animal
 Necrosis Antibodies  >133 publications with Ang-2 and Necrosis
 Adenocarcinoma Antibodies  >109 publications with Ang-2 and Adenocarcinoma
 Liver Diseases Antibodies  >88 publications with Ang-2 and Liver Diseases
 Kidney Diseases Antibodies  >88 publications with Ang-2 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >87 publications with Ang-2 and Neoplasms, Experimental
 Heart Diseases Antibodies  >86 publications with Ang-2 and Heart Diseases
 Neoplasm Metastasis Antibodies  >82 publications with Ang-2 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1492 publications with Ang-2 and Vascular
 Muscle Antibodies  >195 publications with Ang-2 and Muscle
 Lung Antibodies  >169 publications with Ang-2 and Lung
 Brain Antibodies  >159 publications with Ang-2 and Brain
 Embryonic Tissue Antibodies  >153 publications with Ang-2 and Embryonic Tissue
 Liver Antibodies  >135 publications with Ang-2 and Liver
 Kidney Antibodies  >125 publications with Ang-2 and Kidney
 Eye Antibodies  >109 publications with Ang-2 and Eye
 Placenta Antibodies  >79 publications with Ang-2 and Placenta
 Bone Marrow Antibodies  >76 publications with Ang-2 and Bone Marrow
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