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anti-ANGPT2 antibody :: Mouse Angiopoietin 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS838047 anti-ANGPT2 antibody
Unit / Price
0.1 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Angiopoietin 2 (ANGPT2), Monoclonal Antibody

 Also Known As   

Angiopoietin 2 antibody

 Product Synonym Names    Monoclonal Angiopoietin 2; Anti-Angiopoietin 2; angiopoietin-2a; angiopoietin-2B; ANGP2; ANGPT2; Tie2-ligand; AGPT2; ANG-2; ANG2; angiopoietin2; Angiopoietin-2
 Product Gene Name   

anti-ANGPT2 antibody

[Similar Products]
 Matching Pairs    Capture Antibody: Angiopoietin 2 Clone #M72047 (MBS838277)
Detection Antibody: Angiopoietin 2 Clone #M72048 (MBS838047)
Comments: Excellent pair for ELISA
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601922
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 Clonality    Monoclonal
 Isotype    IgG1 kappa - Fab fragment
 Clone Number    M72048
 Host    Mouse
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 Specificity    Human
 Purity/Purification    > 95% pure
Angiopoietin 2 antibodies screened using Phage Display system. Expressed in and purified from E Coli.
 Form/Format    Supplied as liquid in 50 mM Potassium Phosphate, 10 mM Boric Acid, 150 mM NaCl, pH 7
 Concentration    > 1 mg/ml (lot specific)
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 Protein Type    Recombinant
 Biological Significance    Angiopoietin 2 binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin 2 antibody was produced as a recombinant Fab monoclonal antibody in a Phage Display system. This anti-Angiopoietin 2 antibody is used for detection of human Angiopoietin 2 in ELISA. The concentration of the antibody ranges from 1 mg/ml to 25 mg/ml depending on the lot. Recombinant Fab monoclonal antibodies have a number of advantages over standard antibodies including; improved scale up for batch consistency, more efficient binding so less antibody required, more accurate binding meaning fewer conjugation issues, less non specific due to removal of the Fc region, more flexibility for purification and labeling through a C-terminal His tag.
 Expression System    E Coli
 Tag/Conjugate    His tag
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 Preparation and Storage    Store at -20 degree C in small aliquots. Avoid repeated freeze thawing.
 Other Notes    Small volumes of anti-ANGPT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ANGPT2 antibody

   Recombinant Fab monoclonal Angiopoietin 2 antibody
 Product Categories/Family for anti-ANGPT2 antibody    Differentiation & Development
 Applications Tested/Suitable for anti-ANGPT2 antibody   

ELISA (EIA)

 Application Notes for anti-ANGPT2 antibody    Angiopoietin 2 antibody pair: MBS838277 can be used as the capture antibody with MBS838047 as the detection antibody for detection of human Angiopoietin 2 in ELISA
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NCBI/Uniprot data below describe general gene information for ANGPT2. It may not necessarily be applicable to this product.
 NCBI GI #    219518053
 NCBI GeneID    285
 NCBI Accession #    AAI43903.1 [Other Products]
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 UniProt Secondary Accession #    Q9NRR7; Q9P2Y7; A0AV38; A8K205; B7ZLM7 [Other Products]
 UniProt Related Accession #    O15123 [Other Products]
 Molecular Weight    56,848 Da [Similar Products]
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 NCBI Official Full Name    Angiopoietin 2
 NCBI Official Synonym Full Names    angiopoietin 2
 NCBI Official Symbol    ANGPT2 [Similar Products]
 NCBI Official Synonym Symbols   
ANG2; AGPT2
[Similar Products]
 NCBI Protein Information    angiopoietin-2
 UniProt Protein Name    Angiopoietin-2
 Protein Family    Angiopoietin
 UniProt Gene Name    ANGPT2 [Similar Products]
 UniProt Synonym Gene Names    ANG-2 [Similar Products]
 UniProt Entry Name    ANGP2_HUMAN
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 NCBI Summary for ANGPT2    The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANGPT2    ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; cell projection; plasma membrane; extracellular region; nucleus

Molecular Function: protein binding; metal ion binding; receptor tyrosine kinase binding; receptor binding

Biological Process: Tie receptor signaling pathway; organ regeneration; maternal process involved in pregnancy; signal transduction; negative regulation of blood vessel endothelial cell migration; response to organic cyclic substance; germ cell development; negative regulation of positive chemotaxis; positive regulation of angiogenesis; response to radiation; negative regulation of angiogenesis; response to mechanical stimulus; response to hypoxia; response to glucose stimulus; angiogenesis; response to activity; blood coagulation; leukocyte migration
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 Research Articles on ANGPT2    1. the positive correlation between Ang-2 and Tie-2 levels in metastatic subjects, implies that cases with a Tie-2 level above the upper limits, together with higher level of Ang-2 seem to be highly predictive of metastases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANGPT2 antibodyPathways associated with anti-ANGPT2 antibody
 Reference Product  PubMed Publications
 ANGPT1 antibody  >333 publications with ANGPT2 and ANGPT1
 VEGFA antibody  >153 publications with ANGPT2 and VEGFA
 FGF2 antibody  >63 publications with ANGPT2 and FGF2
 TEK antibody  >49 publications with ANGPT2 and TEK
 TIE1 antibody  >36 publications with ANGPT2 and TIE1
 KDR antibody  >34 publications with ANGPT2 and KDR
 FLT1 antibody  >24 publications with ANGPT2 and FLT1
 FOXO1 antibody  >8 publications with ANGPT2 and FOXO1
 ETS1 antibody  >6 publications with ANGPT2 and ETS1
 FLT4 antibody  >2 publications with ANGPT2 and FLT4
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Tie2 Signaling Pathway antibodies  Tie2 Signaling Pathway Diagram
Diseases associated with anti-ANGPT2 antibodyOrgans/Tissues associated with anti-ANGPT2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >285 publications with ANGPT2 and Cardiovascular Diseases
 Inflammation Antibodies  >251 publications with ANGPT2 and Inflammation
 Disease Models, Animal Antibodies  >174 publications with ANGPT2 and Disease Models, Animal
 Necrosis Antibodies  >122 publications with ANGPT2 and Necrosis
 Heart Diseases Antibodies  >84 publications with ANGPT2 and Heart Diseases
 Liver Diseases Antibodies  >84 publications with ANGPT2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >82 publications with ANGPT2 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >80 publications with ANGPT2 and Kidney Diseases
 Liver Neoplasms Antibodies  >77 publications with ANGPT2 and Liver Neoplasms
 Hypertension Antibodies  >74 publications with ANGPT2 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1388 publications with ANGPT2 and Vascular
 Muscle Antibodies  >186 publications with ANGPT2 and Muscle
 Lung Antibodies  >150 publications with ANGPT2 and Lung
 Embryonic Tissue Antibodies  >149 publications with ANGPT2 and Embryonic Tissue
 Brain Antibodies  >144 publications with ANGPT2 and Brain
 Liver Antibodies  >127 publications with ANGPT2 and Liver
 Kidney Antibodies  >114 publications with ANGPT2 and Kidney
 Eye Antibodies  >100 publications with ANGPT2 and Eye
 Placenta Antibodies  >75 publications with ANGPT2 and Placenta
 Bone Marrow Antibodies  >69 publications with ANGPT2 and Bone Marrow
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