NP_000028.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Detects ~200kDa.
NCBI Official Full Name
ankyrin-1 isoform 3
NCBI Official Synonym Full Names
ankyrin 1
NCBI Protein Information
ankyrin-1
UniProt Protein Name
Ankyrin-1
UniProt Synonym Protein Names
Ankyrin-R; Erythrocyte ankyrin
UniProt Synonym Gene Names
UniProt Entry Name
ANK1_HUMAN
NCBI Summary for ANK
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
UniProt Comments for ANK
Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.
Product References and Citations for anti-ANK antibody
1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353-92.
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Products associated with anti-ANK antibody
Pathways associated with anti-ANK antibody
Diseases associated with anti-ANK antibody
Organs/Tissues associated with anti-ANK antibody
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