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anti-PROC antibody :: Anti-Human Protein C, Clone 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135033 anti-PROC antibody
Unit / Price
0.1 mg  /  $315 +1 FREE 8GB USB
0.5 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Anti-Human Protein C, Clone 2 (PROC), Monoclonal Antibody

 Also Known As   

Anti-Human Protein C, Clone 2

 Product Gene Name   

anti-PROC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (128175996..128186822). Location: 2q13-q14
 OMIM    176860
 3D Structure    ModBase 3D Structure for P04070
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    5072
 Host    Host: Mouse; Source: Mouse ascites
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Liquid
 Concentration    5.0 mg/ml (lot specific)
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 Immunogen    Full length native protein (purified) (Human).
 Target Information    Recognises Protein C
 Target Molecular Weight    62000
 Buffer    50% Glycerol
 Extinction Coefficient    1.36
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 Preparation and Storage    Store at -20 degree C. Shelf Life: 12 months from delivery
 Other Notes    Small volumes of anti-PROC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PROC antibody

   Clone number AHPC-5072. Recognizes human protein C. Mouse monoclonal of isotype IgG2b.
 Product Categories/Family for anti-PROC antibody    Protein C; Monoclonal Antibodies to Human Protein C
 Applications Tested/Suitable for anti-PROC antibody   

ELISA (EIA), Western Blot (WB), AP

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NCBI/Uniprot data below describe general gene information for PROC. It may not necessarily be applicable to this product.
 NCBI GI #    4506115
 NCBI GeneID    5624
 NCBI Accession #    NP_000303.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000312.3 [Other Products]
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 UniProt Primary Accession #    P04070 [Other Products]
 UniProt Secondary Accession #    Q15189; Q15190; Q16001; Q53S74; Q9UC55 [Other Products]
 UniProt Related Accession #    P04070 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    vitamin K-dependent protein C preproprotein
 NCBI Official Synonym Full Names    protein C (inactivator of coagulation factors Va and VIIIa)
 NCBI Official Symbol    PROC [Similar Products]
 NCBI Official Synonym Symbols   
PC; APC; PROC1; THPH3; THPH4
[Similar Products]
 NCBI Protein Information    vitamin K-dependent protein C; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV
 UniProt Protein Name    Vitamin K-dependent protein C
 UniProt Synonym Protein Names   
Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV
 Protein Family    Vitamin K-dependent protein
 UniProt Gene Name    PROC [Similar Products]
 UniProt Entry Name    PROC_HUMAN
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 NCBI Summary for PROC    This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
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 UniProt Comments for PROC    PROC: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive (THPH4). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare. Belongs to the peptidase S1 family.

Protein type: Protease; Apoptosis; EC 3.4.21.69

Chromosomal Location of Human Ortholog: 2q13-q14

Cellular Component: Golgi lumen; endoplasmic reticulum lumen; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: cellular protein metabolic process; negative regulation of blood coagulation; post-translational protein modification; proteolysis; blood coagulation; peptidyl-glutamic acid carboxylation; leukocyte migration; negative regulation of apoptosis

Disease: Thrombophilia Due To Protein C Deficiency, Autosomal Recessive; Thrombophilia Due To Protein C Deficiency, Autosomal Dominant
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 Research Articles on PROC    1. These results show a variable contribution of basic residues comprising the activated protein C exosite, with significant contributions from Lys39, Arg67, and Arg74 to forming a FVIIIa-interactive site.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PROC antibodyPathways associated with anti-PROC antibody
 Reference Product  PubMed Publications
 GGCX antibody  >6 publications with PROC and GGCX
 PROS1 antibody  >4 publications with PROC and PROS1
 THBD antibody  >2 publications with PROC and THBD
 PROCR antibody  >2 publications with PROC and PROCR
 SERPINA5 antibody  >1 publications with PROC and SERPINA5
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with anti-PROC antibodyOrgans/Tissues associated with anti-PROC antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >716 publications with PROC and Neoplasms
 Cardiovascular Diseases Antibodies  >129 publications with PROC and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >119 publications with PROC and Cell Transformation, Neoplastic
 Drug Toxicity Antibodies  >118 publications with PROC and Drug Toxicity
 Liver Diseases Antibodies  >90 publications with PROC and Liver Diseases
 Thrombosis Antibodies  >76 publications with PROC and Thrombosis
 Kidney Diseases Antibodies  >65 publications with PROC and Kidney Diseases
 Liver Neoplasms Antibodies  >65 publications with PROC and Liver Neoplasms
 Protein C Deficiency Antibodies  >59 publications with PROC and Protein C Deficiency
 Blood Coagulation Disorders Antibodies  >59 publications with PROC and Blood Coagulation Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >699 publications with PROC and Brain
 Liver Antibodies  >597 publications with PROC and Liver
 Kidney Antibodies  >382 publications with PROC and Kidney
 Lung Antibodies  >200 publications with PROC and Lung
 Spleen Antibodies  >87 publications with PROC and Spleen
 Connective Tissue Antibodies  >87 publications with PROC and Connective Tissue
 Testis Antibodies  >61 publications with PROC and Testis
 Uterus Antibodies  >22 publications with PROC and Uterus
 Mammary Gland Antibodies  >15 publications with PROC and Mammary Gland
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