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anti-PROS1 antibody :: Anti-Human Protein S Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135099 anti-PROS1 antibody
Unit / Price
0.1 mg  /  $320 +1 FREE 8GB USB
0.5 mg  /  $605 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Anti-Human Protein S (PROS1), Monoclonal Antibody

 Also Known As   

Anti-Human Protein S

 Product Gene Name   

anti-PROS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (93591881..93692934, complement). Location: 3q11.2
 OMIM    176880
 3D Structure    ModBase 3D Structure for P07225
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    5092
 Host    Host: Mouse; Source: Mouse ascites
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Liquid
 Concentration    5.0 mg/ml (lot specific)
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 Immunogen    Full length native protein (purified) (Human).
 Target Information    Recognises Protein S
 Target Molecular Weight    69000
 Buffer    50% Glycerol
 Extinction Coefficient    1.36
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 Preparation and Storage    Store at -20 degree C. Shelf Life: 12 months from delivery
 Other Notes    Small volumes of anti-PROS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PROS1 antibody

   Clone number AHPS-5092. Reactive to: Human protein S. Mouse monoclonal of isotype IgG1.
 Product Categories/Family for anti-PROS1 antibody    Protein S; Monoclonal Antibodies to Human Protein S
 Applications Tested/Suitable for anti-PROS1 antibody   

ELISA (EIA), Radioimmunoassay (RIA), Western Blot (WB), AP

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NCBI/Uniprot data below describe general gene information for PROS1. It may not necessarily be applicable to this product.
 NCBI GI #    192447438
 NCBI GeneID    5627
 NCBI Accession #    NP_000304.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000313.3 [Other Products]
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 UniProt Primary Accession #    P07225 [Other Products]
 UniProt Secondary Accession #    Q15518; Q7Z715; Q9UCZ8; A8KAC9; D3DN28 [Other Products]
 UniProt Related Accession #    P07225 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    vitamin K-dependent protein S preproprotein
 NCBI Official Synonym Full Names    protein S (alpha)
 NCBI Official Symbol    PROS1 [Similar Products]
 NCBI Official Synonym Symbols   
PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6
[Similar Products]
 NCBI Protein Information    vitamin K-dependent protein S; protein Sa; vitamin K-dependent plasma protein S
 UniProt Protein Name    Vitamin K-dependent protein S
 Protein Family    Proline--tRNA ligase
 UniProt Gene Name    PROS1 [Similar Products]
 UniProt Synonym Gene Names    PROS [Similar Products]
 UniProt Entry Name    PROS_HUMAN
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 NCBI Summary for PROS1    This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]
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 UniProt Comments for PROS1    PROS1: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal dominant (THPH5). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal recessive (THPH6). A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: Golgi membrane; extracellular space; endoplasmic reticulum membrane; Golgi lumen; plasma membrane; extracellular region

Molecular Function: endopeptidase inhibitor activity; calcium ion binding

Biological Process: platelet activation; fibrinolysis; platelet degranulation; cellular protein metabolic process; regulation of complement activation; innate immune response; blood coagulation; post-translational protein modification; proteolysis; leukocyte migration; peptidyl-glutamic acid carboxylation

Disease: Thrombophilia Due To Protein S Deficiency, Autosomal Recessive; Thrombophilia Due To Protein S Deficiency, Autosomal Dominant
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 Research Articles on PROS1    1. The tyrosine kinase receptor MER is activated by PROS and mediates its inhibitory effect on VEGF-A-induced EC proliferation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PROS1 antibodyPathways associated with anti-PROS1 antibody
 Reference Product  PubMed Publications
 PROC antibody  >4 publications with PROS1 and PROC
 C4BPB antibody  >2 publications with PROS1 and C4BPB
 C4BPA antibody  >2 publications with PROS1 and C4BPA
 TYRO3 antibody  >1 publications with PROS1 and TYRO3
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-PROS1 antibodyOrgans/Tissues associated with anti-PROS1 antibody
 Disease Name  Pubmed Publications
 Blood Coagulation Disorders Antibodies  >62 publications with PROS1 and Blood Coagulation Disorders
 Thrombosis Antibodies  >50 publications with PROS1 and Thrombosis
 Cardiovascular Diseases Antibodies  >37 publications with PROS1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >37 publications with PROS1 and Vascular Diseases
 Venous Thrombosis Antibodies  >28 publications with PROS1 and Venous Thrombosis
 Thromboembolism Antibodies  >10 publications with PROS1 and Thromboembolism
 Venous Thromboembolism Antibodies  >9 publications with PROS1 and Venous Thromboembolism
 Neoplasms Antibodies  >7 publications with PROS1 and Neoplasms
 THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT Antibodies  >4 publications with PROS1 and THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT
 Inflammation Antibodies  >3 publications with PROS1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >8 publications with PROS1 and Vascular
 Liver Antibodies  >5 publications with PROS1 and Liver
 Thyroid Antibodies  >2 publications with PROS1 and Thyroid
 Kidney Antibodies  >2 publications with PROS1 and Kidney
 Brain Antibodies  >2 publications with PROS1 and Brain
 Heart Antibodies  >1 publications with PROS1 and Heart
 Lung Antibodies  >1 publications with PROS1 and Lung
 Muscle Antibodies  >1 publications with PROS1 and Muscle
 Intestine Antibodies  >1 publications with PROS1 and Intestine
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