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anti-APOA1 antibody :: anti-Human Apolipoprotein AI (Apo AI) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS311600 anti-APOA1 antibody
Unit / Price
1 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein AI (Apo AI) (APOA1), Monoclonal Antibody

 Also Known As   

MAb to Apolipoprotein AI

 Product Synonym Names    Monoclonal Antibody to Human Apolipoprotein AI (Apo AI)
 Product Gene Name   

anti-APOA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (116706469..116708338, complement). Location: 11q23-q24
 OMIM    105200
 3D Structure    ModBase 3D Structure for P02647
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 Clonality    Monoclonal
 Isotype    IgG2a, kappa
 Clone Number    057-10029
 Host    Host: Mouse
Source: Ascites
 Species Reactivity    Human
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 Specificity    Apolipoprotein AI (Apo AI)
This product does not cross react with Apo AII or Apo B in competitive RIA.
 Purity/Purification    >90% pure (SDS-PAGE). Protein A chromatography
Product is 0.2um filtered.
 Form/Format    Purified, Liquid
 Concentration    5.3mg/ml (OD280nm, E^0.1% = 1.4) (lot specific)
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 Immunogen    Human high density lipoprotein
 Affinity Constant    5 x 10^6 L/m (determined by RIA followed by Scatchard plot analysis)
 Buffer    10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
 Preservative    0.1% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-APOA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-APOA1 antibody    Monoclonal Antibodies to Lipoproteins
NCBI/Uniprot data below describe general gene information for APOA1. It may not necessarily be applicable to this product.
 NCBI GI #    296635
 NCBI GeneID    335
 NCBI Accession #    CAA25519.1 [Other Products]
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 UniProt Primary Accession #    P02647 [Other Products]
 UniProt Secondary Accession #    Q6LDN9; Q6Q785; Q9UCS8; Q9UCT8; A8K866 [Other Products]
 UniProt Related Accession #    P02647; Q6LEJ8; Q8TDB0; Q9Y355 [Other Products]
 Molecular Weight    30,778 Da [Similar Products]
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 NCBI Official Full Name    apolipoprotein AI
 NCBI Official Synonym Full Names    apolipoprotein A-I
 NCBI Official Symbol    APOA1 [Similar Products]
 NCBI Official Synonym Symbols   
MGC117399
[Similar Products]
 NCBI Protein Information    apolipoprotein A-I; apo-AI; apoA-I; OTTHUMP00000043268; OTTHUMP00000069346; OTTHUMP00000069347; OTTHUMP00000069348
 UniProt Protein Name    Apolipoprotein A-I
 UniProt Synonym Protein Names   
Apolipoprotein A1
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOA1 [Similar Products]
 UniProt Entry Name    APOA1_HUMAN
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 NCBI Summary for APOA1    This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq]
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 UniProt Comments for APOA1    Function: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Ref.20

Subunit structure: Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Ref.25 Ref.31

Subcellular location: Secreted.

Tissue specificity: Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. Ref.33

Post-translational modification: Palmitoylated. Ref.28Phosphorylation sites are present in the extracelllular medium.

Involvement in disease: Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [

MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant. Ref.37 Ref.38Defects in APOA1 are a cause of the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1) [

MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by the absence of plasma HDL, accumulation of cholesteryl esters, premature coronary artery disease, hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. In HDLD1 patients, ApoA-I fails to associate with HDL probably because of the faulty conversion of pro-ApoA-I molecules into mature chains, either due to a defect in the converting enzyme activity or a specific structural defect in Tangier ApoA-I. Ref.37 Ref.38Defects in APOA1 are the cause of amyloid polyneuropathy-nephropathy Iowa type (AMYLIOWA) [

MIM:107680]; also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III. AMYLIOWA is a hereditary generalized amyloidosis due to deposition of amyloid mainly constituted by apolipoprotein A1. The clinical picture is dominated by neuropathy in the early stages of the disease and nephropathy late in the course. Death is due in most cases to renal amyloidosis. Severe peptic ulcer disease can occurr in some and hearing loss is frequent. Cataracts is present in several, but vitreous opacities are not observed. Ref.37 Ref.38 Ref.43 Ref.44Defects in APOA1 are a cause of amyloidosis type 8 (AMYL8) [

MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Ref.37 Ref.38 Ref.46

Sequence similarities: Belongs to the apolipoprotein A1/A4/E family.
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 Research Articles on APOA1    1. Apolipoprotein A1, the major protein of sHDL, forms a hollow structure that cradles a central compact lipid core.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOA1 antibodyPathways associated with anti-APOA1 antibody
 Reference Product  PubMed Publications
 APOB antibody  >325 publications with APOA1 and APOB
 ABCA1 antibody  >77 publications with APOA1 and ABCA1
 CETP antibody  >36 publications with APOA1 and CETP
 LCAT antibody  >27 publications with APOA1 and LCAT
 SCARB1 antibody  >18 publications with APOA1 and SCARB1
 Products by Pathway  Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
Diseases associated with anti-APOA1 antibodyOrgans/Tissues associated with anti-APOA1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >280 publications with APOA1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >218 publications with APOA1 and Vascular Diseases
 Atherosclerosis Antibodies  >168 publications with APOA1 and Atherosclerosis
 Coronary Disease Antibodies  >126 publications with APOA1 and Coronary Disease
 Dyslipidemias Antibodies  >125 publications with APOA1 and Dyslipidemias
 Arteriosclerosis Antibodies  >110 publications with APOA1 and Arteriosclerosis
 Hyperlipidemias Antibodies  >96 publications with APOA1 and Hyperlipidemias
 Diabetes Mellitus Antibodies  >76 publications with APOA1 and Diabetes Mellitus
 Obesity Antibodies  >63 publications with APOA1 and Obesity
 Insulin Resistance Antibodies  >61 publications with APOA1 and Insulin Resistance
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >512 publications with APOA1 and Blood
 Heart Antibodies  >109 publications with APOA1 and Heart
 Liver Antibodies  >104 publications with APOA1 and Liver
 Muscle Antibodies  >20 publications with APOA1 and Muscle
 Brain Antibodies  >15 publications with APOA1 and Brain
 Ovary Antibodies  >9 publications with APOA1 and Ovary
 Intestine Antibodies  >7 publications with APOA1 and Intestine
 Lung Antibodies  >4 publications with APOA1 and Lung
 Pancreas Antibodies  >4 publications with APOA1 and Pancreas
 Embryonic Tissue Antibodies  >3 publications with APOA1 and Embryonic Tissue
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