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anti-APOB antibody :: Mouse anti-Rat Apolipoprotein B (APOB) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2061921 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-APOB antibody
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $290 +1 FREE 8GB USB
1 mg  /  $690 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein B (APOB), Monoclonal Antibody

 Also Known As   

PE-Linked Monoclonal Antibody to Apolipoprotein B (APOB)

 Product Gene Name   

anti-APOB antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Apolipoprotein B (APOB) (MBS2012785)
PE Conjugated Antibody: Apolipoprotein B (APOB) (MBS2061921)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X04506 mRNA
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Rat
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 Concentration    500ug/ml (lot specific)
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 Immunogen    Phe3329~Arg3494
 Conjugation    PE
 Unconjugated Antibody    The unconjugated antibody version of this item is also available as catalog #MBS2012785
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 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-APOB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-APOB antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for APOB. It may not necessarily be applicable to this product.
 NCBI GI #    553189
 NCBI GeneID    338
 NCBI Accession #    AAA51752.1 [Other Products]
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 UniProt Secondary Accession #    O00502; P78479; P78480; P78481; Q13779; Q13785; Q13786; Q13787; Q13788; Q4ZG63; Q53QC8 [Other Products]
 UniProt Related Accession #    P04114 [Other Products]
 Molecular Weight    515,605 Da
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 NCBI Official Full Name    apolipoprotein B, partial
 NCBI Official Synonym Full Names    apolipoprotein B
 NCBI Official Symbol    APOB [Similar Products]
 NCBI Official Synonym Symbols   
FLDB; LDLCQ4; apoB-48; apoB-100
[Similar Products]
 NCBI Protein Information    apolipoprotein B-100
 UniProt Protein Name    Apolipoprotein B-100
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOB [Similar Products]
 UniProt Synonym Gene Names    Apo B-100; Apo B-48 [Similar Products]
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 NCBI Summary for APOB    This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APOB    APOB: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Defects in APOB are a cause of familial hypobetalipoproteinemia type 1 (FHBL1). A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.

Protein type: Carrier; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p24.1

Cellular Component: actin cytoskeleton; cell soma; chylomicron; cytoplasm; cytosol; early endosome; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endosome membrane; extracellular region; extracellular space; Golgi apparatus; intracellular membrane-bound organelle; plasma membrane

Molecular Function: cholesterol transporter activity; heparin binding; low-density lipoprotein receptor binding; phospholipid binding; protein binding

Biological Process: cellular protein catabolic process; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; leukocyte migration; lipoprotein biosynthetic process; lipoprotein catabolic process; lipoprotein metabolic process; receptor-mediated endocytosis; response to virus; retinoid metabolic process

Disease: Hypercholesterolemia, Autosomal Dominant, Type B; Hypobetalipoproteinemia, Familial, 1
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 Research Articles on APOB    1. LDLR A(+)A(+) genotype, ApoB X(+) allele and ApoE E4 allele increased the risk of premature coronary artery disease by 1.8, 2.1 and 12.1 respectively.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-APOB antibodyDiseases associated with anti-APOB antibody
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 LDL-mediated Lipid Transport Pathway antibodies  LDL-mediated Lipid Transport Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3466 publications with APOB and Cardiovascular Diseases
 Dyslipidemias Antibodies  >3011 publications with APOB and Dyslipidemias
 Atherosclerosis Antibodies  >2567 publications with APOB and Atherosclerosis
 Hyperlipidemias Antibodies  >2474 publications with APOB and Hyperlipidemias
 Coronary Disease Antibodies  >1871 publications with APOB and Coronary Disease
 Heart Diseases Antibodies  >1618 publications with APOB and Heart Diseases
 Hypercholesterolemia Antibodies  >1496 publications with APOB and Hypercholesterolemia
 Hyperlipoproteinemia Type II Antibodies  >725 publications with APOB and Hyperlipoproteinemia Type II
 Insulin Resistance Antibodies  >711 publications with APOB and Insulin Resistance
 Hypertriglyceridemia Antibodies  >628 publications with APOB and Hypertriglyceridemia
Organs/Tissues associated with anti-APOB antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8096 publications with APOB and Blood
 Liver Antibodies  >2245 publications with APOB and Liver
 Heart Antibodies  >1483 publications with APOB and Heart
 Intestine Antibodies  >596 publications with APOB and Intestine
 Kidney Antibodies  >433 publications with APOB and Kidney
 Muscle Antibodies  >314 publications with APOB and Muscle
 Brain Antibodies  >145 publications with APOB and Brain
 Lung Antibodies  >126 publications with APOB and Lung
 Embryonic Tissue Antibodies  >57 publications with APOB and Embryonic Tissue
 Spleen Antibodies  >57 publications with APOB and Spleen
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