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anti-APOE antibody :: anti-Human Apolipoprotein E (E2, E3, E4) (Apo E) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS310899 anti-APOE antibody
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 Product Name   

Apolipoprotein E (E2, E3, E4) (Apo E) (APOE), Monoclonal Antibody

 Also Known As   

MAb to Apolipoprotein E

 Product Synonym Names    Monoclonal Antibody to Apolipoprotein E (Apo E)
 Product Gene Name   

anti-APOE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (45409039..45412650). Location: 19q13.2
 OMIM    104310
 3D Structure    ModBase 3D Structure for P02649
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    E6D7
 Host    Host: Mouse
Source: Ascites
 Species Reactivity    Human
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 Specificity    Apolipoprotein E (E2, E3, E4) (Apo E)
Specific to Human Apo E. Does not cross-react with mouse and rabbit. Reacts to the E2, E3 and E4 isoforms of apolipoprotein E.
 Purity/Purification    Protein A chromatography
 Form/Format    Purified, Liquid
 Concentration    1mg/ml (OD280nm) (lot specific)
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 Immunogen    Synthetic peptide spanning the polymorphic aa position 158 of Apo E
 Affinity Constant    Not determined
 Buffer    PBS
 Preservative    No
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
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 Preparation and Storage    Short-term store at 2 to 8 degree C. Long term, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-APOE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-APOE antibody    Monoclonal Antibodies to Lipoproteins
 Applications Tested/Suitable for anti-APOE antibody   

EIA/ELISA, Immunohistochemistry - Formalin/Paraffin, Immunoprecipitation, Western Blot

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NCBI/Uniprot data below describe general gene information for APOE. It may not necessarily be applicable to this product.
 NCBI GI #    114039
 NCBI GeneID    348
 NCBI Accession #    P02649.1 [Other Products]
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 UniProt Primary Accession #    P02649 [Other Products]
 UniProt Secondary Accession #    Q9P2S4; B2RC15; C0JYY5 [Other Products]
 UniProt Related Accession #    P02649; Q13791; Q6LA97; Q6LBZ1; Q8TCZ8 [Other Products]
 Molecular Weight    36,154 Da [Similar Products]
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 NCBI Official Full Name    Apolipoprotein E
 NCBI Official Synonym Full Names    apolipoprotein E
 NCBI Official Symbol    APOE [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    apolipoprotein E; apo-E; apolipoprotein E3; OTTHUMP00000159143; OTTHUMP00000197075; OTTHUMP00000197076; OTTHUMP00000197077
 UniProt Protein Name    Apolipoprotein E
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOE [Similar Products]
 UniProt Entry Name    APOE_HUMAN
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 NCBI Summary for APOE    Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq]
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 UniProt Comments for APOE    APOE: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. Defects in APOE are a cause of hyperlipoproteinemia type 3 (HLPP3); also known as familial dysbetalipoproteinemia. Individuals with HLPP3 are clinically characterized by xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons and on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause. The vast majority of the patients are homozygous for APOE*2 alleles. More severe cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease (CAD). Individuals carrying the common APOE*4 variant are at higher risk of CAD. Genetic variations in APOE are associated with Alzheimer disease type 2 (AD2). It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. The APOE*4 allele is genetically associated with the common late onset familial and sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known. Defects in APOE are a cause of sea-blue histiocyte disease (SBHD); also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease and other sphingolipidoses. Defects in APOE are a cause of lipoprotein glomerulopathy (LPG). LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese and Chinese origin. The disorder has rarely been described in Caucasians. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Secreted; Secreted, signal peptide; Lipid-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: Golgi apparatus; extracellular space; microtubule; endoplasmic reticulum; lysosome; early endosome; dendrite; extracellular region; nuclear envelope; extracellular matrix; chylomicron; extrinsic to external side of plasma membrane; membrane; cell soma; late endosome; cytoplasm; plasma membrane; nucleus; vesicle

Molecular Function: lipid transporter activity; heparin binding; identical protein binding; protein homodimerization activity; metal chelating activity; beta-amyloid binding; cholesterol binding; antioxidant activity; protein binding; low-density lipoprotein receptor binding; cholesterol transporter activity; hydroxyapatite binding; phospholipid binding; tau protein binding; lipid binding

Biological Process: phototransduction, visible light; lipoprotein catabolic process; negative regulation of MAP kinase activity; cGMP-mediated signaling; positive regulation of axon extension; positive regulation of membrane protein ectodomain proteolysis; axon regeneration in the peripheral nervous system; synaptic transmission, cholinergic; intracellular transport; triacylglycerol catabolic process; oligodendrocyte differentiation; negative regulation of neuron apoptosis; cholesterol catabolic process; long-chain fatty acid transport; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; positive regulation of nitric-oxide synthase activity; negative regulation of blood coagulation; lipoprotein metabolic process; regulation of axon extension; positive regulation of lipid biosynthetic process; negative regulation of blood vessel endothelial cell migration; maintenance of cellular localization; response to reactive oxygen species; cholesterol homeostasis; response to ethanol; positive regulation of cGMP biosynthetic process; lipoprotein biosynthetic process; regulation of gene expression; protein import; negative regulation of endothelial cell proliferation; nitric oxide mediated signal transduction; regulation of neuronal synaptic plasticity; response to dietary excess; vasodilation; response to insulin stimulus; positive regulation of low-density lipoprotein receptor catabolic process; phospholipid efflux; retinoid metabolic process; negative regulation of cholesterol biosynthetic process; aging; receptor-mediated endocytosis; response to retinoic acid; negative regulation of lipid biosynthetic process; neurite regeneration; cholesterol efflux; cytoskeleton organization and biogenesis; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; triacylglycerol metabolic process; reverse cholesterol transport; fatty acid homeostasis; negative regulation of inflammatory response; artery morphogenesis

Disease: Macular Degeneration, Age-related, 1; Alzheimer Disease 2; Alzheimer Disease 4; Lipoprotein Glomerulopathy; Sea-blue Histiocyte Disease
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Product References and Citations for anti-APOE antibody

   • Norman, R.R., et al., "Apolipoprotein E genotyping in Alzheimer's Disease", Ann. N.Y. Acad. Science, 801 (Reviews).
• Munoz, D.G., et al., (2000), "Causes of Alzheimer's disease", CMAJ, 162(1): 65-72.
• Tomiyama, T.,
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 Research Articles on APOE    1. Investigate if apolipoprotein epsilon4 allele moderates the influence of earthquake exposure on survivor health. Findings suggest a genetic variation in the apolipoprotein E gene may modify the health effects of the stress from natural disaster exposure.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOE antibodyPathways associated with anti-APOE antibody
 Reference Product  PubMed Publications
 APP antibody  >388 publications with APOE and APP
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Statin Pathway antibodies  Statin Pathway Diagram
Diseases associated with anti-APOE antibodyOrgans/Tissues associated with anti-APOE antibody
 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >5371 publications with APOE and Central Nervous System Diseases
 Cardiovascular Diseases Antibodies  >4508 publications with APOE and Cardiovascular Diseases
 Neurodegenerative Diseases Antibodies  >4412 publications with APOE and Neurodegenerative Diseases
 Alzheimer Disease Antibodies  >4331 publications with APOE and Alzheimer Disease
 Vascular Diseases Antibodies  >4246 publications with APOE and Vascular Diseases
 Atherosclerosis Antibodies  >3402 publications with APOE and Atherosclerosis
 Arteriosclerosis Antibodies  >2934 publications with APOE and Arteriosclerosis
 Hyperlipidemias Antibodies  >1592 publications with APOE and Hyperlipidemias
 Inflammation Antibodies  >888 publications with APOE and Inflammation
 Hypercholesterolemia Antibodies  >883 publications with APOE and Hypercholesterolemia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3126 publications with APOE and Brain
 Vascular Antibodies  >2856 publications with APOE and Vascular
 Liver Antibodies  >1487 publications with APOE and Liver
 Heart Antibodies  >1081 publications with APOE and Heart
 Muscle Antibodies  >843 publications with APOE and Muscle
 Nerve Antibodies  >493 publications with APOE and Nerve
 Bone Antibodies  >377 publications with APOE and Bone
 Kidney Antibodies  >368 publications with APOE and Kidney
 Lung Antibodies  >190 publications with APOE and Lung
 Intestine Antibodies  >152 publications with APOE and Intestine
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