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anti-DDC antibody :: Mouse Aromatic L-Amino Acid Decarboxylase, DOPA Decarboxylase, DDC Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS609374 anti-DDC antibody
Unit / Price
0.1 mL  /  $745 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aromatic L-Amino Acid Decarboxylase, DOPA Decarboxylase, DDC, Monoclonal Antibody

 Also Known As   

Aromatic L-Amino Acid Decarboxylase, DOPA Decarboxylase, DDC

 Product Synonym Names    Anti -Aromatic L-Amino Acid Decarboxylase, DOPA Decarboxylase, DDC
 Product Gene Name   

anti-DDC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (50526134..50633154, complement). Location: 7p12.2
 OMIM    107930
 3D Structure    ModBase 3D Structure for P20711
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    3H4
 Host    Mouse
 Species Reactivity    Bovine, Canine, Guinea Pig, Human, Monkey, Rabbit, Rat, Sheep
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 Specificity    Recognizes human DDC at ~50kD. Species Crossreactvity
 Purity/Purification    Ascites
 Form/Format    Supplied as a liquid in 0.02% sodium azide, 40% glycerol.
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 Immunogen    A 16 amino acid peptide sequence near the NH2-terminus of human DDC coupled to KLH
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-DDC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DDC antibody

   DDC (EC 1.1.128) belongs to the family group II Decarboxylase (DDC, GAD, HDC and TYRD). DDC catalyzes the formation of tryptamine from L-tyrosine. It also acts on 5-hydroxy-LO-tryptophan and dihydroxy-L-Phenylalanine (DOPA). Human DDC (480 aa, chromosome 7p11) is a homodimer in the native state. It requires pyridoxal phosphate as a cofactor.
 Product Categories/Family for anti-DDC antibody    Antibodies; Abs to Enzymes, Decarboxylase
 Applications Tested/Suitable for anti-DDC antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-DDC antibody    Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1:1000-1:5000 (ECL) (~50kD band)
ELISA: 1:10,000-1:50,000 using 1ug/ml control peptide per well.
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NCBI/Uniprot data below describe general gene information for DDC. It may not necessarily be applicable to this product.
 NCBI GI #    257538
 NCBI GeneID    1644
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 UniProt Primary Accession #    P20711 [Other Products]
 UniProt Secondary Accession #    Q16723; Q75MJ6 [Other Products]
 UniProt Related Accession #    P20711; Q53Y41; Q5W5T9; Q6IBS8 [Other Products]
 Molecular Weight    53,926 Da [Similar Products]
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 NCBI Official Full Name    aromatic L-amino acid decarboxylase
 NCBI Official Synonym Full Names    dopa decarboxylase (aromatic L-amino acid decarboxylase)
 NCBI Official Symbol    DDC [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    aromatic-L-amino-acid decarboxylase; OTTHUMP00000159585; OTTHUMP00000209020; OTTHUMP00000209022; OTTHUMP00000209025; OTTHUMP00000209026
 UniProt Protein Name    Aromatic-L-amino-acid decarboxylase
 UniProt Synonym Protein Names   
DOPA decarboxylase
 Protein Family    Aromatic-L-amino-acid decarboxylase
 UniProt Gene Name    DDC [Similar Products]
 UniProt Synonym Gene Names    AADC [Similar Products]
 UniProt Entry Name    DDC_HUMAN
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 NCBI Summary for DDC    The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
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 UniProt Comments for DDC    DDC: Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Homodimer. Belongs to the group II decarboxylase family.

Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tryptophan; Nuclear receptor co-regulator; EC; Lyase; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 7p12.2

Cellular Component: synaptic vesicle; cell soma; axon; cytosol

Molecular Function: protein domain specific binding; amino acid binding; aromatic-L-amino-acid decarboxylase activity; protein binding; enzyme binding; pyridoxal phosphate binding

Biological Process: circadian rhythm; amino acid metabolic process; catecholamine biosynthetic process; indolalkylamine biosynthetic process; multicellular organismal aging; isoquinoline alkaloid metabolic process; dopamine biosynthetic process; serotonin biosynthetic process; synaptic vesicle amine transport; phytoalexin metabolic process; response to pyrethroid

Disease: Aromatic L-amino Acid Decarboxylase Deficiency
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 Research Articles on DDC    1. the human DDC gene undergoes complex processing, leading to the formation of multiple mRNA isoforms in tumor cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DDC antibodyDiseases associated with anti-DDC antibody
 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Biosynthesis Of Amine And Peptide Hormones Pathway antibodies  Biosynthesis Of Amine And Peptide Hormones Pathway Diagram
 Catecholamine Biosynthesis Pathway antibodies  Catecholamine Biosynthesis Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Hormones Pathway antibodies  Metabolism Of Hormones Pathway Diagram
 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >268 publications with DDC and Drug Toxicity
 Neoplasms Antibodies  >139 publications with DDC and Neoplasms
 Central Nervous System Diseases Antibodies  >78 publications with DDC and Central Nervous System Diseases
 Liver Diseases Antibodies  >72 publications with DDC and Liver Diseases
 Mental Disorders Antibodies  >51 publications with DDC and Mental Disorders
 Carcinoma Antibodies  >46 publications with DDC and Carcinoma
 Neurodegenerative Diseases Antibodies  >39 publications with DDC and Neurodegenerative Diseases
 Necrosis Antibodies  >34 publications with DDC and Necrosis
 Leukemia Antibodies  >33 publications with DDC and Leukemia
 Pain Antibodies  >25 publications with DDC and Pain
Organs/Tissues associated with anti-DDC antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >371 publications with DDC and Blood
 Liver Antibodies  >256 publications with DDC and Liver
 Brain Antibodies  >224 publications with DDC and Brain
 Nerve Antibodies  >60 publications with DDC and Nerve
 Kidney Antibodies  >59 publications with DDC and Kidney
 Lung Antibodies  >41 publications with DDC and Lung
 Intestine Antibodies  >25 publications with DDC and Intestine
 Eye Antibodies  >22 publications with DDC and Eye
 Prostate Antibodies  >17 publications with DDC and Prostate
 Pancreas Antibodies  >14 publications with DDC and Pancreas
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