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anti-AURKB antibody :: Mouse Aurora Kinase B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140364 anti-AURKB antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aurora Kinase B (AURKB), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Aurora Kinase B

 Product Synonym Names    AURKB Antibody; Aurora Kinase B, Mouse Anti Human; Serine/threonine-protein kinase 12; Aurora kinase B; Serine/threonine-protein kinase aurora-B; Aurora- and Ipl1-like midbody-associated protein 1; Aurora/IPL1-related kinase 2; Aurora-related kinase 2; AIM-1; ARK-2; STK-1; AURKB; AIK2; AIM1; ARK2; STK12; AurB; IPL1; STK5; aurkb-sv1; aurkb-sv2
 Product Gene Name   

anti-AURKB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604970
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 Clonality    Monoclonal
 Isotype    IgG2b heavy chain and kappa light chain
 Clone Number    PAT2B1AT
 Host    Mouse
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 Purity/Purification    AURKB antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
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 Immunogen    Anti-human AURKB mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human AURKB amino acids 1-344 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-AURKB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AURKB antibody

   Introduction: Aurora Kinase B (AURKB) belongs to a family of mitotic serine/threonine kinases. AURKB connects with chromosomes for the period of prophase prior to relocalizing to the spindle at anaphase. AURKB localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB controls chromosome segregation through the control of microtubule-kinetochore attachment and cytokinesis. AURKB is required for kinetochore localization of BUB1 and SGOL1. AURKB expression during the G2/M phase transition is firmly coordinated with histone H3 phosphorylation, while overexpression is seen in many kinds of cancers. AURKB phosphorylates ''Ser-10'' and ''Ser-28'' of histone H3 during mitosis. AURKB is a component of the CPC (chromosomal passenger complex), which is a complex that acts as a key regulator of mitosis. High level expression of AURKB is seen in the thymus, which is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. AURKB is expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
 Product Categories/Family for anti-AURKB antibody    MONOCLONAL ANTIBODIES, ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme
 Applications Tested/Suitable for anti-AURKB antibody   

ELISA (EIA), Immunofluorescence (IF)

 Application Notes for anti-AURKB antibody    AURKB antibody has been tested by ELISA and Immunofluorescence analyses to assure specificity and reactivity. Since applications vary, each investigation should be titrated by a reagent to obtain optimal results. Recommended dilution range for Immunofluorescence is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.
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NCBI/Uniprot data below describe general gene information for AURKB. It may not necessarily be applicable to this product.
 NCBI GI #    83776600
 NCBI GeneID    9212
 NCBI Accession #    NP_004208.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004217.3 [Other Products]
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 UniProt Secondary Accession #    O14630; O60446; O95083; Q96DV5; Q9UQ46; B4DNM4; C7G533; C7G534; C7G535; D3DTR4; J9JID1 [Other Products]
 UniProt Related Accession #    Q96GD4 [Other Products]
 Molecular Weight    39,467 Da
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 NCBI Official Full Name    aurora kinase B isoform 1
 NCBI Official Synonym Full Names    aurora kinase B
 NCBI Official Symbol    AURKB [Similar Products]
 NCBI Official Synonym Symbols   
AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
[Similar Products]
 NCBI Protein Information    aurora kinase B; ARK-2; STK-1; aurora 1; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and Ipl1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B
 UniProt Protein Name    Aurora kinase B
 UniProt Synonym Protein Names   
Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B
 Protein Family    Aurora kinase
 UniProt Gene Name    AURKB [Similar Products]
 UniProt Synonym Gene Names    AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; AIM-1; ARK-2; Aurora-related kinase 2 [Similar Products]
 UniProt Entry Name    AURKB_HUMAN
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 NCBI Summary for AURKB    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
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 UniProt Comments for AURKB    AurB: a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation.

Protein type: Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: spindle microtubule; spindle; spindle pole centrosome; midbody; spindle midzone; nucleus; cytosol; condensed nuclear chromosome, pericentric region; chromocenter

Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; ATP binding

Biological Process: positive regulation of cytokinesis; spindle stabilization; spindle checkpoint; spindle midzone assembly involved in mitosis; protein amino acid autophosphorylation; regulation of chromosome segregation; negative regulation of transcription from RNA polymerase II promoter; attachment of spindle microtubules to kinetochore; protein amino acid phosphorylation; negative regulation of cytokinesis; cell proliferation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; abscission; histone modification; mitotic cell cycle; negative regulation of protein binding; negative regulation of B cell apoptosis; aging
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 Research Articles on AURKB    1. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AURKB antibodyPathways associated with anti-AURKB antibody
 Reference Product  PubMed Publications
 INCENP antibody  >94 publications with AURKB and INCENP
 BIRC5 antibody  >83 publications with AURKB and BIRC5
 CDCA8 antibody  >25 publications with AURKB and CDCA8
 NDC80 antibody  >23 publications with AURKB and NDC80
 CDC20 antibody  >12 publications with AURKB and CDC20
 BUB1B antibody  >10 publications with AURKB and BUB1B
 KIF23 antibody  >9 publications with AURKB and KIF23
 KIF20A antibody  >4 publications with AURKB and KIF20A
 CENPA antibody  >4 publications with AURKB and CENPA
 RACGAP1 antibody  >1 publications with AURKB and RACGAP1
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Aurora C Signaling Pathway antibodies  Aurora C Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
Diseases associated with anti-AURKB antibodyOrgans/Tissues associated with anti-AURKB antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >30 publications with AURKB and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >28 publications with AURKB and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >21 publications with AURKB and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >21 publications with AURKB and Lung Neoplasms
 Nervous System Diseases Antibodies  >18 publications with AURKB and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >16 publications with AURKB and Neoplasm Metastasis
 Pancreatic Neoplasms Antibodies  >14 publications with AURKB and Pancreatic Neoplasms
 Disease Models, Animal Antibodies  >13 publications with AURKB and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >12 publications with AURKB and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >11 publications with AURKB and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with AURKB and Blood
 Lung Antibodies  >27 publications with AURKB and Lung
 Liver Antibodies  >22 publications with AURKB and Liver
 Brain Antibodies  >20 publications with AURKB and Brain
 Prostate Antibodies  >17 publications with AURKB and Prostate
 Bone Antibodies  >16 publications with AURKB and Bone
 Bone Marrow Antibodies  >13 publications with AURKB and Bone Marrow
 Testis Antibodies  >11 publications with AURKB and Testis
 Lymph Antibodies  >11 publications with AURKB and Lymph
 Lymph Node Antibodies  >11 publications with AURKB and Lymph Node
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