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anti-B2M antibody :: Mouse anti-Human B2M / Beta 2 Microglobulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245229
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B2M / Beta 2 Microglobulin, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal [clone 2213] (IgG1) to Human B2M / Beta 2 Microglobulin

 Product Synonym Names    Anti-B2M / Beta 2 Microglobulin Antibody (clone 2213) IHC-plus; B2M; Beta 2 Microglobulin; Beta-2-microglobulin; Beta-2-microglobin; Human B2M; Beta 2 Microglobulin
 Product Gene Name   

anti-B2M antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 241600
 3D Structure    ModBase 3D Structure for P61769
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2213
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Specific for human beta 2 microglobulin. B2M is the beta chain of MHC class I molecules. The precursor protein has a molecular weight of approximately 14 kD and is 119 amino acids in length.
 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 8.0, 0.05% sodium azide, 10% glycerol.
 Concentration    1.1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Highly pure beta-2-microglobulin from human urine.
 Immunogen    B2M / Beta 2 Microglobulin antibody was raised against highly pure beta-2-microglobulin from human urine.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-B2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-B2M antibody

   Beta 2-microglobulin is the low molecular weight component of HLA antigens and as such is involved in the presentation of endogenous antigens, activation of T lymphocytes and functional emergence of natural killer cells. It is found in the serum of normal individuals and in the urine in elevated amounts in patients with Wilson disease, cadmium poisoning and other conditions leading renal tubular dysfunction.
 Applications Tested/Suitable for anti-B2M antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-B2M antibody    ELISA, IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-B2M antibody    Anti-B2M antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-B2M antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-B2M antibody    Anti-B2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-B2M antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for B2M. It may not necessarily be applicable to this product.
 NCBI GI #    4757826
 NCBI GeneID    567
 NCBI Accession #    NP_004039.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004048.2 [Other Products]
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 UniProt Primary Accession #    P61769 [Other Products]
 UniProt Secondary Accession #    P01884; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4 [Other Products]
 UniProt Related Accession #    P61769 [Other Products]
 Molecular Weight    13,715 Da
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 NCBI Official Full Name    beta-2-microglobulin
 NCBI Official Synonym Full Names    beta-2-microglobulin
 NCBI Official Symbol    B2M [Similar Products]
 NCBI Protein Information    beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules
 UniProt Protein Name    Beta-2-microglobulin
 Protein Family    Beta-2-microglobulin
 UniProt Gene Name    B2M [Similar Products]
 UniProt Entry Name    B2MG_HUMAN
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 NCBI Summary for B2M    This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
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 UniProt Comments for B2M    B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; endoplasmic reticulum lumen; early endosome membrane; cytoplasm; extracellular region; plasma membrane; MHC class I protein complex; external side of plasma membrane

Molecular Function: identical protein binding; protein binding

Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; iron ion homeostasis; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Disease: Hypoproteinemia, Hypercatabolic
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 Research Articles on B2M    1. Serum beta2-microglobulin levels correlate with tumor stage in MM.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-B2M antibodyPathways associated with anti-B2M antibody
 Reference Product  PubMed Publications
 HLA-A antibody  >15 publications with B2M and HLA-A
 TFRC antibody  >12 publications with B2M and TFRC
 HFE antibody  >3 publications with B2M and HFE
 LILRB1 antibody  >1 publications with B2M and LILRB1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with anti-B2M antibodyOrgans/Tissues associated with anti-B2M antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >82 publications with B2M and Cardiovascular Diseases
 Kidney Diseases Antibodies  >69 publications with B2M and Kidney Diseases
 Carcinoma Antibodies  >41 publications with B2M and Carcinoma
 Inflammation Antibodies  >36 publications with B2M and Inflammation
 Renal Insufficiency Antibodies  >28 publications with B2M and Renal Insufficiency
 Disease Models, Animal Antibodies  >28 publications with B2M and Disease Models, Animal
 Proteinuria Antibodies  >25 publications with B2M and Proteinuria
 Liver Diseases Antibodies  >21 publications with B2M and Liver Diseases
 Necrosis Antibodies  >20 publications with B2M and Necrosis
 Autoimmune Diseases Antibodies  >19 publications with B2M and Autoimmune Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >273 publications with B2M and Blood
 Kidney Antibodies  >108 publications with B2M and Kidney
 Bone Antibodies  >76 publications with B2M and Bone
 Bone Marrow Antibodies  >59 publications with B2M and Bone Marrow
 Liver Antibodies  >40 publications with B2M and Liver
 Heart Antibodies  >30 publications with B2M and Heart
 Skin Antibodies  >28 publications with B2M and Skin
 Brain Antibodies  >27 publications with B2M and Brain
 Muscle Antibodies  >27 publications with B2M and Muscle
 Vascular Antibodies  >24 publications with B2M and Vascular
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