Q5T2L0
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UniProt Related Accession #
NCBI Official Full Name
B7-H4 protein
NCBI Official Synonym Full Names
V-set domain containing T cell activation inhibitor 1
NCBI Official Synonym Symbols
B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; FLJ22418; RP11-229A19.4; VTCN1 [Similar Products]
NCBI Protein Information
V-set domain-containing T-cell activation inhibitor 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4
UniProt Protein Name
Uncharacterized protein
UniProt Entry Name
Q5T2L0_HUMAN
NCBI Summary for VTCN1
B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]
UniProt Comments for VTCN1
VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: integral to membrane; external side of plasma membrane
Molecular Function: receptor binding
Biological Process: response to protozoan; immune system process; positive regulation of T cell proliferation; negative regulation of T cell activation
Research Articles on VTCN1
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Products associated with anti-VTCN1 antibody
Diseases associated with anti-VTCN1 antibody
Organs/Tissues associated with anti-VTCN1 antibody
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