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anti-VTCN1 antibody :: Mouse anti-Human B7H4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS608880
Immunohistochemistry
Unit / Price
0.2 mg  /  $645 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B7H4 (VTCN1), Monoclonal Antibody

★Popular Item★
 Also Known As   

B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287, PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation Inhibitor 1, VCTN1)

 Product Synonym Names    Anti -B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287, PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation Inhibitor 1, VCTN1)
 Product Gene Name   

anti-VTCN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    chromosome: 1; Location: 1p13.1
 3D Structure    ModBase 3D Structure for Q5T2L0
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10B249
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human B7H4.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
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 Immunogen    Human B7H4
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-VTCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VTCN1 antibody

   B7H4, also known as B7x, is a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7H4 deficient mice are only minimally affected; suggesting B7H4 is important in the fine tuning of the T-cell mediated immune response. B7H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC).
 Product Categories/Family for anti-VTCN1 antibody    Antibodies; Abs to T Cells
 Applications Tested/Suitable for anti-VTCN1 antibody   

Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

 Application Notes for anti-VTCN1 antibody    Suitable for use in Flow Cytometry and Immunohistochemistry.
Dilution: Flow Cytometry: 1:25-1:50; 10ul labels 10e6 cells in 100ul.
Immunohistochemistry (Paraffin): 1:50. Does not require digestion pretreatment of paraffin sections. Does not require heat-treatment prior to staining paraffin sections.
Immunohistochemistry: Frozen sections
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 Immunohistochemistry of anti-VTCN1 antibody    Paraffin embedded breast carcinoma stained with MBS608880
anti-VTCN1 antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for VTCN1. It may not necessarily be applicable to this product.
 NCBI GI #    42357719
 NCBI GeneID    79679
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 UniProt Primary Accession #    Q5T2L0 [Other Products]
 UniProt Related Accession #    Q5T2L0; Q6P097; Q7Z7D3 [Other Products]
 Molecular Weight    31,259 Da [Similar Products]
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 NCBI Official Full Name    B7-H4 protein
 NCBI Official Synonym Full Names    V-set domain containing T cell activation inhibitor 1
 NCBI Official Symbol    VTCN1 [Similar Products]
 NCBI Official Synonym Symbols   
B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; FLJ22418; RP11-229A19.4; VTCN1
[Similar Products]
 NCBI Protein Information    V-set domain-containing T-cell activation inhibitor 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4
 UniProt Protein Name    Uncharacterized protein
 Protein Family    V-set domain containing T-cell activation inhibitor
 UniProt Gene Name    VTCN1 [Similar Products]
 UniProt Entry Name    Q5T2L0_HUMAN
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 NCBI Summary for VTCN1    B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]
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 UniProt Comments for VTCN1    VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: receptor binding

Biological Process: response to protozoan; immune system process; positive regulation of T cell proliferation; negative regulation of T cell activation
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 Research Articles on VTCN1    1. Novel role of B7-H4 molecule in the suppressive effect of hBMSCs on T-cell activation and proliferation.
2. B7-H4 directly promotes malignant transformation of ovarian cancer cell line.
3. B7-H4 gene polymorphism may contribute to the sporadic breast cancer risk and prognosis in Chinese Han women.
4. Observational study of gene-disease association. (HuGE Navigator)
5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
6. renal cell carcinoma patients are more likely to have detectable sB7x compared with controls and higher sB7x levels correlate with advanced tumor stage
7. B7-H4 was expressed more often in pancreatic ductal carcinoma than was p53.
8. B7-H4 expression was low in normal ovaries and in benign tumors while half of early stage and two-thirds of late stage cancers over-expressed B7-H4.
9. Tight regulation of B7-H4 expression at the translational level is observed in normal peripheral tissues and a potential role indicated in the evasion of tumor immunity.
10. patients with renal cell carcinoma (RCC) tumors expressing both B7-H4 and B7-H1 are at an even greater risk of death from RCC
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VTCN1 antibodyDiseases associated with anti-VTCN1 antibody
 Reference Product  PubMed Publications
 BTLA antibody  >3 publications with VTCN1 and BTLA
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with VTCN1 and Neoplasms
 Carcinoma Antibodies  >16 publications with VTCN1 and Carcinoma
 Ovarian Neoplasms Antibodies  >14 publications with VTCN1 and Ovarian Neoplasms
 Gonadal Disorders Antibodies  >14 publications with VTCN1 and Gonadal Disorders
 Ovarian Diseases Antibodies  >14 publications with VTCN1 and Ovarian Diseases
 Breast Neoplasms Antibodies  >8 publications with VTCN1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >8 publications with VTCN1 and Adenocarcinoma
 Inflammation Antibodies  >5 publications with VTCN1 and Inflammation
 Lung Neoplasms Antibodies  >4 publications with VTCN1 and Lung Neoplasms
 Kidney Diseases Antibodies  >4 publications with VTCN1 and Kidney Diseases
Organs/Tissues associated with anti-VTCN1 antibody
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >5 publications with VTCN1 and Pancreas
 Lung Antibodies  >5 publications with VTCN1 and Lung
 Kidney Antibodies  >4 publications with VTCN1 and Kidney
 Liver Antibodies  >3 publications with VTCN1 and Liver
 Bone Antibodies  >3 publications with VTCN1 and Bone
 Ovary Antibodies  >3 publications with VTCN1 and Ovary
 Prostate Antibodies  >2 publications with VTCN1 and Prostate
 Uterus Antibodies  >2 publications with VTCN1 and Uterus
 Placenta Antibodies  >1 publications with VTCN1 and Placenta
 Embryonic Tissue Antibodies  >1 publications with VTCN1 and Embryonic Tissue
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