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anti-BACE1 antibody :: Rabbit BACE1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS607346 anti-BACE1 antibody
Unit / Price
0.1 mL  /  $480 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BACE1, Monoclonal Antibody

 Also Known As   

BACE1 (Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Beta-site APP Cleaving Enzyme 1, BACE 1, APP beta Secretase, Aspartyl Protease 2, Asp 2, ASP2, Asp-2, Beta Secretase 1, Beta Secretase, Beta Site Amyloid beta A4 Precursor Protein Cleaving Enzy

 Product Synonym Names    Anti -BACE1 (Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Beta-site APP Cleaving Enzyme 1, BACE 1, APP beta Secretase, Aspartyl Protease 2, Asp 2, ASP2, Asp-2, Beta Secretase 1, Beta Secretase, Beta Site Amyloid beta A4 Precursor Protein Cleaving Enzy
 Product Gene Name   

anti-BACE1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (117156402..117186972, complement). Location: 11q23.2-q23.3
 OMIM    604252
 3D Structure    ModBase 3D Structure for P56817
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    10E7
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human BACE. Species crossreactivity: mouse, rat.
 Form/Format    Supplied in 10 mM sodium HEPES (pH 7.5), 150mM NaCl, 100ug/ml BSA and 50% glycerol.
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 Immunogen    Synthetic peptide corresponding to residues surrounding Asp490 of human BACE protein (KLH- coupled).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-BACE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BACE1 antibody

   -secretase (BACE) is an aspartic acid proteinase that catalyses the initial step in APP processing by cleaving and releasing a soluble, extracellular APP- (sAPP) ectodomain and generating a membrane-bound, carboxy-terminal fragment consisting of 99 amino acids (CTF99). Additional processing of CTF99 by -secretase generates the amyloid -peptide (A) that forms aggregates in the brains of Alzheimer disease (AD) patients. BACE is an attractive target for inhibitors in AD therapy since it catalyses the first and rate limiting step in amyloidogenic APP processing (1). Pro-BACE-1 is synthesized in the ER before it is transported to the trans-Golgi network to undergo maturation (2). BACE1 functions as a dimer and is phosphorylated at Ser498 by casein kinase 1, which is necessary for recycling back to the membrane from the early endosome (3,4).
 Product Categories/Family for anti-BACE1 antibody    Antibodies; Abs to Apoptosis
 Applications Tested/Suitable for anti-BACE1 antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-BACE1 antibody    Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Immunoprecipitation: 1:50.
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NCBI/Uniprot data below describe general gene information for BACE1. It may not necessarily be applicable to this product.
 NCBI GI #    333755186
 NCBI GeneID    23621
 NCBI Accession #    NP_001193978.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001207049.1 [Other Products]
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 UniProt Primary Accession #    P56817 [Other Products]
 UniProt Secondary Accession #    Q9BYB9; Q9BYC0; Q9BYC1; Q9UJT5; Q9ULS1; A0M8W7; B0YIU9; E9PE65; H7BXJ9 [Other Products]
 UniProt Related Accession #    P56817 [Other Products]
 Molecular Weight    55,711 Da [Similar Products]
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 NCBI Official Full Name    beta-secretase 1 isoform F
 NCBI Official Synonym Full Names    beta-site APP-cleaving enzyme 1
 NCBI Official Symbol    BACE1 [Similar Products]
 NCBI Official Synonym Symbols   
ASP2; BACE; HSPC104
[Similar Products]
 NCBI Protein Information    beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme
 UniProt Protein Name    Beta-secretase 1
 UniProt Synonym Protein Names   
Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
 Protein Family    Beta-secretase
 UniProt Gene Name    BACE1 [Similar Products]
 UniProt Synonym Gene Names    BACE; KIAA1149; ASP2; Asp 2 [Similar Products]
 UniProt Entry Name    BACE1_HUMAN
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 NCBI Summary for BACE1    Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
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 UniProt Comments for BACE1    BACE: an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described.

Protein type: Membrane protein, integral; EC 3.4.23.46; Protease

Chromosomal Location of Human Ortholog: 11q23.2-q23.3

Cellular Component: multivesicular body; Golgi apparatus; cytoplasmic vesicle membrane; cell surface; endoplasmic reticulum; axon; integral to plasma membrane; late endosome; integral to membrane; plasma membrane; trans-Golgi network; endosome

Molecular Function: protein binding; enzyme binding; beta-amyloid binding; beta-aspartyl-peptidase activity; aspartic-type endopeptidase activity

Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; proteolysis
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 Research Articles on BACE1    1. we found that BACE1 levels were significantly lower in AD compared to CN subjects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BACE1 antibodyPathways associated with anti-BACE1 antibody
 Reference Product  PubMed Publications
 APP antibody  >1035 publications with BACE1 and APP
 PSEN1 antibody  >282 publications with BACE1 and PSEN1
 RTN3 antibody  >17 publications with BACE1 and RTN3
 GGA3 antibody  >12 publications with BACE1 and GGA3
 GGA1 antibody  >12 publications with BACE1 and GGA1
 NCSTN antibody  >4 publications with BACE1 and NCSTN
 GGA2 antibody  >3 publications with BACE1 and GGA2
 PLSCR1 antibody  >1 publications with BACE1 and PLSCR1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
Diseases associated with anti-BACE1 antibodyOrgans/Tissues associated with anti-BACE1 antibody
 Disease Name  Pubmed Publications
 Alzheimer Disease Antibodies  >1150 publications with BACE1 and Alzheimer Disease
 Brain Diseases Antibodies  >1103 publications with BACE1 and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1081 publications with BACE1 and Neurodegenerative Diseases
 Neoplasms Antibodies  >114 publications with BACE1 and Neoplasms
 Necrosis Antibodies  >91 publications with BACE1 and Necrosis
 Memory Disorders Antibodies  >56 publications with BACE1 and Memory Disorders
 Inflammation Antibodies  >52 publications with BACE1 and Inflammation
 Cognition Disorders Antibodies  >46 publications with BACE1 and Cognition Disorders
 Learning Disorders Antibodies  >44 publications with BACE1 and Learning Disorders
 Nerve Degeneration Antibodies  >21 publications with BACE1 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >940 publications with BACE1 and Brain
 Blood Antibodies  >154 publications with BACE1 and Blood
 Kidney Antibodies  >86 publications with BACE1 and Kidney
 Vascular Antibodies  >56 publications with BACE1 and Vascular
 Embryonic Tissue Antibodies  >26 publications with BACE1 and Embryonic Tissue
 Ovary Antibodies  >23 publications with BACE1 and Ovary
 Muscle Antibodies  >22 publications with BACE1 and Muscle
 Liver Antibodies  >22 publications with BACE1 and Liver
 Ear Antibodies  >15 publications with BACE1 and Ear
 Pancreas Antibodies  >13 publications with BACE1 and Pancreas
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