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anti-BPI antibody :: Mouse anti-Human BACTERICIDAL PERMEABILITY INCREASING PROTEIN Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604935 anti-BPI antibody
Unit / Price
0.1 mg  /  $940 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI), Monoclonal Antibody

 Also Known As   

BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI, CAP57)

 Product Synonym Names    Anti -BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI, CAP57)
 Product Gene Name   

anti-BPI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 13; NC_007311.4 (67778730..67805090)
 3D Structure    ModBase 3D Structure for P17453
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9G128
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). 3F9 recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
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 Immunogen    Human BPI.
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 Preparation and Storage    -20 degree C
 Other Notes    Small volumes of anti-BPI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BPI antibody

   The antimicrobial protein BPI is a 55kD protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21kD bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage
 Product Categories/Family for anti-BPI antibody    Antibodies; Abs to Proteins
 Application Notes for anti-BPI antibody    Suitable for use in immunoassays both as coating and as detector.
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NCBI/Uniprot data below describe general gene information for BPI. It may not necessarily be applicable to this product.
 NCBI GI #    27806919
 NCBI GeneID    280734
 NCBI Accession #    NP_776320.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_173895.2 [Other Products]
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 UniProt Primary Accession #    P17453 [Other Products]
 UniProt Secondary Accession #    Q3T0P4 [Other Products]
 UniProt Related Accession #    P17453 [Other Products]
 Molecular Weight    53,442 Da [Similar Products]
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 NCBI Official Full Name    bactericidal permeability-increasing protein
 NCBI Official Symbol    BPI [Similar Products]
 NCBI Protein Information    bactericidal permeability-increasing protein
 UniProt Protein Name    Bactericidal permeability-increasing protein
 Protein Family    Bactericidal permeability-increasing protein
 UniProt Gene Name    BPI [Similar Products]
 UniProt Entry Name    BPI_BOVIN
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 UniProt Comments for BPI    Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

Subunit structure: Monomer. Homodimer; disulfide-linked

Subcellular location: Secreted

By similarity. Cytoplasmic granule membrane

By similarity. Note: Membrane-associated in polymorphonuclear Leukocytes (PMN) granules

Tissue specificity: Restricted to cells of the myeloid series.

Domain: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested

Sequence similarities: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
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 Research Articles on BPI    1. Polymorphism in BPI has no effect on daughter yield deviation for somatic cell score in Holstein cattle.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-BPI antibodyOrgans/Tissues associated with anti-BPI antibody
 Disease Name  Pubmed Publications
 Pain Antibodies  >274 publications with BPI and Pain
 Nervous System Diseases Antibodies  >235 publications with BPI and Nervous System Diseases
 Neoplasms Antibodies  >127 publications with BPI and Neoplasms
 Immune System Diseases Antibodies  >67 publications with BPI and Immune System Diseases
 Colitis Antibodies  >22 publications with BPI and Colitis
 Breast Neoplasms Antibodies  >18 publications with BPI and Breast Neoplasms
 Nausea Antibodies  >18 publications with BPI and Nausea
 Liver Diseases Antibodies  >15 publications with BPI and Liver Diseases
 Pulmonary Fibrosis Antibodies  >13 publications with BPI and Pulmonary Fibrosis
 Arthritis, Rheumatoid Antibodies  >11 publications with BPI and Arthritis, Rheumatoid
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >27 publications with BPI and Liver
 Skin Antibodies  >19 publications with BPI and Skin
 Intestine Antibodies  >17 publications with BPI and Intestine
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