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anti-BAP1 antibody :: Mouse anti-Human BAP1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120218
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAP1, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human BAP1

 Product Synonym Names    Homo sapiens BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1); hucep-6; FLJ35406;FLJ37180; HUCEP-13; KIAA0272; DKFZp686N04275
 Product Gene Name   

anti-BAP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    156240
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2058C3a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-BAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BAP1 antibody

   The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-BAP1 antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

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 Quality Control of anti-BAP1 antibody    Western blot analysis of immunized recombinant protein, using anti-BAP1 monoclonal antibody.
anti-BAP1 antibody Quality Control image
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 Quality Control #2 of anti-BAP1 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-BAP1 antibody Quality Control #2 image
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 Immunocytochemistry (ICC) of anti-BAP1 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-BAP1 mAb. [Lot No.2058C3a-1]
anti-BAP1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for BAP1. It may not necessarily be applicable to this product.
 NCBI GI #    507116140
 NCBI GeneID    8314
 NCBI Accession #    NP_004647.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004656 [Other Products]
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 UniProt Secondary Accession #    Q6LEM0; Q7Z5E8; A8K993 [Other Products]
 UniProt Related Accession #    Q92560 [Other Products]
 Molecular Weight    80,362 Da
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 NCBI Official Full Name    Homo sapiens BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1), mRNA
 NCBI Official Synonym Full Names    BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
 NCBI Official Symbol    BAP1 [Similar Products]
 NCBI Official Synonym Symbols   
UCHL2; hucep-6; HUCEP-13
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase BAP1; cerebral protein 6; cerebral protein-13
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase BAP1
 UniProt Synonym Protein Names   
BRCA1-associated protein 1; Cerebral protein 6
 Protein Family    BON1-associated protein
 UniProt Gene Name    BAP1 [Similar Products]
 UniProt Entry Name    BAP1_HUMAN
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 NCBI Summary for BAP1    This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
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 UniProt Comments for BAP1    BAP1: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1. Highly expressed in testis, placenta and ovary. Expressed in breast. Belongs to the peptidase C12 family. BAP1 subfamily.

Protein type: Ubiquitin conjugating system; Protease; Ubiquitin-specific protease; EC 3.4.19.12; Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: peptidase activity; protein binding; ubiquitin-specific protease activity; chromatin binding

Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; protein deubiquitination; regulation of cell cycle; protein modification process; regulation of cell growth

Disease: Tumor Predisposition Syndrome
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 Research Articles on BAP1    1. The combined BAP1-BRAFV600E+ immunoprofile appears to be a constant feature of BAP1 tumor syndrome-associated melanocytic lesions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BAP1 antibodyDiseases associated with anti-BAP1 antibody
 Reference Product  PubMed Publications
 ASXL1 antibody  >10 publications with BAP1 and ASXL1
 HCFC1 antibody  >8 publications with BAP1 and HCFC1
 BMI1 antibody  >6 publications with BAP1 and BMI1
 ASXL2 antibody  >4 publications with BAP1 and ASXL2
 PCGF1 antibody  >1 publications with BAP1 and PCGF1
 RING1 antibody  >1 publications with BAP1 and RING1
 Disease Name  Pubmed Publications
 Uveal melanoma Antibodies  >59 publications with BAP1 and Uveal melanoma
 Nevi and Melanomas Antibodies  >55 publications with BAP1 and Nevi and Melanomas
 Mesothelioma Antibodies  >46 publications with BAP1 and Mesothelioma
 Carcinoma, Renal Cell Antibodies  >38 publications with BAP1 and Carcinoma, Renal Cell
 Kidney Diseases Antibodies  >23 publications with BAP1 and Kidney Diseases
 Lung Neoplasms Antibodies  >18 publications with BAP1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >16 publications with BAP1 and Breast Neoplasms
 Necrosis Antibodies  >12 publications with BAP1 and Necrosis
 Liver Neoplasms Antibodies  >12 publications with BAP1 and Liver Neoplasms
 Liver Diseases Antibodies  >11 publications with BAP1 and Liver Diseases
Organs/Tissues associated with anti-BAP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >33 publications with BAP1 and Skin
 Kidney Antibodies  >28 publications with BAP1 and Kidney
 Lung Antibodies  >27 publications with BAP1 and Lung
 Eye Antibodies  >24 publications with BAP1 and Eye
 Blood Antibodies  >22 publications with BAP1 and Blood
 Liver Antibodies  >22 publications with BAP1 and Liver
 Muscle Antibodies  >16 publications with BAP1 and Muscle
 Brain Antibodies  >8 publications with BAP1 and Brain
 Bone Antibodies  >5 publications with BAP1 and Bone
 Prostate Antibodies  >4 publications with BAP1 and Prostate
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