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anti-BAX antibody :: Mouse BAX Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245269
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAX, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 6A7] (IgG1) to Human BAX

 Product Synonym Names    Anti-BAX Antibody (clone 6A7) IHC-plus; BAX; BCL2-associated X protein; Bcl2-L-4; Apoptosis regulator BAX; Bcl-2-like protein 4; BCL2L4; Human BAX
 Product Gene Name   

anti-BAX antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600040
 3D Structure    ModBase 3D Structure for Q07812
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    6A7
 Host    Mouse
 Species Reactivity    Human, Monkey, Mouse, Rat
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 Specificity    Amino acid:12-24 common to human, mouse, and rat Bax protein.
 Purity/Purification    Affinity Purified
 Form/Format    Phosphate-buffered solution, pH 7.2, 0.09% sodium azide at 0.5 mg/ml.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human BAX.
 Immunogen Type    Synthetic peptide
 Immunogen    BAX antibody was raised against synthetic peptide from human BAX.
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 Preparation and Storage    +4 degree C. Store undiluted.
 Other Notes    Small volumes of anti-BAX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BAX antibody

   Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death.
 Product Categories/Family for anti-BAX antibody    Family: Apoptosis
 Applications Tested/Suitable for anti-BAX antibody   

Immunohistochemistry (IHC - Paraffin), Immunoprecipitation (IP)

 Application Notes for anti-BAX antibody    IHC-P (10 - 12 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-BAX antibody    Anti-BAX antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-BAX antibody Immunohistochemistry (IHC) (IHC) image
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 Immunoprecipitation (IP) of anti-BAX antibody    Extracts from Hela cell lysate was immunoprecipitated with clone 6A7 (lane 1), 4 ug purified monoclonal antibody without cell lysate (clone 6A7, lane 2), or Hela cell lysate without immunoprecipitation (lane 3) were resolved by electrophoresis, transferred to nitrocellulose, and probed with anti-Bax antibody, poly6251.
anti-BAX antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for BAX. It may not necessarily be applicable to this product.
 NCBI GI #    4757838
 NCBI GeneID    581
 NCBI Accession #    NP_004315.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004324.3 [Other Products]
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 UniProt Primary Accession #    Q07812 [Other Products]
 UniProt Secondary Accession #    P55269; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6; A8K4W1 [Other Products]
 UniProt Related Accession #    Q07812 [Other Products]
 Molecular Weight    19,718 Da
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 NCBI Official Full Name    apoptosis regulator BAX isoform beta
 NCBI Official Synonym Full Names    BCL2-associated X protein
 NCBI Official Symbol    BAX [Similar Products]
 NCBI Official Synonym Symbols   
BCL2L4
[Similar Products]
 NCBI Protein Information    apoptosis regulator BAX; bcl2-L-4; Baxdelta2G9; Baxdelta2omega; Baxdelta2G9omega; bcl-2-like protein 4; BCL2-associated X protein omega
 UniProt Protein Name    Apoptosis regulator BAX
 UniProt Synonym Protein Names   
Bcl-2-like protein 4; Bcl2-L-4
 Protein Family    Bax inhibitor
 UniProt Gene Name    BAX [Similar Products]
 UniProt Synonym Gene Names    BCL2L4; Bcl2-L-4 [Similar Products]
 UniProt Entry Name    BAX_HUMAN
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 NCBI Summary for BAX    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BAX    BAX: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37. Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. Belongs to the Bcl-2 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Apoptosis; Tumor suppressor; Mitochondrial

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: mitochondrial permeability transition pore complex; pore complex; endoplasmic reticulum membrane; mitochondrial outer membrane; membrane; mitochondrion; endoplasmic reticulum; nuclear envelope; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; channel activity; BH3 domain binding; lipid binding

Biological Process: hypothalamus development; viral reproduction; regulation of cell cycle; positive regulation of apoptosis; response to toxin; myeloid cell homeostasis; germ cell programmed cell death; B cell apoptosis; germ cell development; regulation of mammary gland epithelial cell proliferation; spermatid differentiation; regulation of mitochondrial membrane potential; development of secondary sexual characteristics; protein insertion into mitochondrial membrane during induction of apoptosis; establishment and/or maintenance of transmembrane electrochemical gradient; negative regulation of neuron apoptosis; negative regulation of protein binding; kidney development; release of cytochrome c from mitochondria; positive regulation of B cell apoptosis; regulation of protein homodimerization activity; vagina development; protein oligomerization; fertilization; unfolded protein response, activation of signaling protein activity; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; retina development in camera-type eye; negative regulation of fibroblast proliferation; reduction of endoplasmic reticulum calcium ion concentration; glycosphingolipid metabolic process; mitochondrial fragmentation during apoptosis; cerebral cortex development; regulation of nitrogen utilization; post-embryonic camera-type eye morphogenesis; positive regulation of pigmentation; regulation of protein heterodimerization activity; T cell homeostatic proliferation; apoptosis; neuron migration; negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis involved in mammary gland involution; release of matrix enzymes from mitochondria; response to salt stress; positive regulation of protein oligomerization; apoptotic mitochondrial changes; B cell homeostatic proliferation; ovarian follicle development; B cell homeostasis; positive regulation of neuron apoptosis; response to gamma radiation; response to axon injury; B cell negative selection; protein homooligomerization; caspase activation; transformed cell apoptosis; mitochondrial fusion; Sertoli cell proliferation; odontogenesis of dentine-containing teeth; endoplasmic reticulum calcium ion homeostasis; neuron apoptosis; homeostasis of number of cells within a tissue; retinal cell programmed cell death; blood vessel remodeling; caspase activation via cytochrome c; positive regulation of release of sequestered calcium ion into cytosol
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 Research Articles on BAX    1. c.-248G > A polymorphism related to risk of cutaneous melanoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BAX antibodyDiseases associated with anti-BAX antibody
 Products by Pathway  Pathway Diagram
 Activation, Translocation And Oligomerization Of BAX Pathway antibodies  Activation, Translocation And Oligomerization Of BAX Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1993 publications with BAX and Necrosis
 Nervous System Diseases Antibodies  >1845 publications with BAX and Nervous System Diseases
 Heart Diseases Antibodies  >1839 publications with BAX and Heart Diseases
 Ischemia Antibodies  >1517 publications with BAX and Ischemia
 Brain Diseases Antibodies  >1376 publications with BAX and Brain Diseases
 Inflammation Antibodies  >1009 publications with BAX and Inflammation
 Breast Neoplasms Antibodies  >950 publications with BAX and Breast Neoplasms
 Liver Diseases Antibodies  >946 publications with BAX and Liver Diseases
 Intestinal Neoplasms Antibodies  >832 publications with BAX and Intestinal Neoplasms
 Neoplasms, Experimental Antibodies  >753 publications with BAX and Neoplasms, Experimental
Organs/Tissues associated with anti-BAX antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3128 publications with BAX and Blood
 Brain Antibodies  >2413 publications with BAX and Brain
 Liver Antibodies  >1715 publications with BAX and Liver
 Lung Antibodies  >1317 publications with BAX and Lung
 Bone Antibodies  >777 publications with BAX and Bone
 Nerve Antibodies  >731 publications with BAX and Nerve
 Prostate Antibodies  >711 publications with BAX and Prostate
 Skin Antibodies  >513 publications with BAX and Skin
 Stomach Antibodies  >490 publications with BAX and Stomach
 Eye Antibodies  >397 publications with BAX and Eye
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