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anti-TNFRSF17 antibody :: Rat anti-Mouse BCMA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602082 anti-TNFRSF17 antibody
Unit / Price
0.1 mg  /  $645 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCMA (TNFRSF17), Monoclonal Antibody

 Also Known As   

BCMA (B Cell Maturation Protein)

 Product Synonym Names    Anti -BCMA (B Cell Maturation Protein)
 Product Gene Name   

anti-TNFRSF17 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (12058964..12061925). Location: 16p13.1
 OMIM    109545
 3D Structure    ModBase 3D Structure for Q02223
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    6D163
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    Recognizes mouse BCMA. Does not cross-react with human BCMA.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.02% sodium azide.
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 Immunogen    Recombinant mouse BCMA:Fc. The extracellular domain of mouse BCMA (aa 1-46) is fused at the C-terminus to a linker peptide (2 aa) and the Fc portion of human IgG1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.  
 Other Notes    Small volumes of anti-TNFRSF17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TNFRSF17 antibody

   BCMA is a member of the TNF receptor superfamily. It binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines. It plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184aa type I transmembrane protein, which contains a 54aa extracellular domain, a 23aa transmembrane domain, and a 107aa extracellular domain.
 Product Categories/Family for anti-TNFRSF17 antibody    Antibodies; Abs to Apoptosis
 Applications Tested/Suitable for anti-TNFRSF17 antibody   

Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

 Application Notes for anti-TNFRSF17 antibody    Suitable for use in Immunoprecipitation, Flow Cytometry, Western Blot and Functional Application.
Dilution: Immunoprecipitation: 1:200
Flow Cytometry: 1:1000
Western Blot: 1:1000
Functional Application: Blocks binding of BAFF to mouse BCMA.
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NCBI/Uniprot data below describe general gene information for TNFRSF17. It may not necessarily be applicable to this product.
 NCBI GI #    14488254
 NCBI GeneID    608
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 UniProt Primary Accession #    Q02223 [Other Products]
 UniProt Related Accession #    Q02223; Q13808; Q2TQ40; Q6PE46 [Other Products]
 Molecular Weight    20,165 Da [Similar Products]
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 NCBI Official Full Name    BCMA
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 17
 NCBI Official Symbol    TNFRSF17 [Similar Products]
 NCBI Official Synonym Symbols   
BCM; BCMA; CD269
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 17; OTTHUMP00000160261; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 17
 UniProt Synonym Protein Names   
B-cell maturation protein
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF17 [Similar Products]
 UniProt Synonym Gene Names    BCM; BCMA [Similar Products]
 UniProt Entry Name    TNR17_HUMAN
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 NCBI Summary for TNFRSF17    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq]
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 UniProt Comments for TNFRSF17    TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: integral to membrane; plasma membrane; endomembrane system

Molecular Function: receptor activity

Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction
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 Research Articles on TNFRSF17    1. Signaling through BCMA enhances B cell activation following exposure to TLR9 agonists, and increased expression in SLE may contribute to the production of IgG autoantibodies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFRSF17 antibodyPathways associated with anti-TNFRSF17 antibody
 Reference Product  PubMed Publications
 TNFSF13B antibody  >55 publications with TNFRSF17 and TNFSF13B
 TNFSF13 antibody  >27 publications with TNFRSF17 and TNFSF13
 TRAF3 antibody  >1 publications with TNFRSF17 and TRAF3
 TRAF2 antibody  >1 publications with TNFRSF17 and TRAF2
 TRAF1 antibody  >1 publications with TNFRSF17 and TRAF1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
Diseases associated with anti-TNFRSF17 antibodyOrgans/Tissues associated with anti-TNFRSF17 antibody
 Disease Name  Pubmed Publications
 Arthritis, Rheumatoid Antibodies  >6 publications with TNFRSF17 and Arthritis, Rheumatoid
 Multiple Myeloma Antibodies  >5 publications with TNFRSF17 and Multiple Myeloma
 Leukemia Antibodies  >4 publications with TNFRSF17 and Leukemia
 Nervous System Diseases Antibodies  >2 publications with TNFRSF17 and Nervous System Diseases
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >1 publications with TNFRSF17 and Leukemia, Lymphocytic, Chronic, B-Cell
 Blood Coagulation Disorders Antibodies  >1 publications with TNFRSF17 and Blood Coagulation Disorders
 Colitis Antibodies  >1 publications with TNFRSF17 and Colitis
 Neoplasm Invasiveness Antibodies  >1 publications with TNFRSF17 and Neoplasm Invasiveness
 Burkitt Lymphoma Antibodies  >1 publications with TNFRSF17 and Burkitt Lymphoma
 Colorectal Neoplasms Antibodies  >1 publications with TNFRSF17 and Colorectal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >4 publications with TNFRSF17 and Lymph Node
 Pharynx Antibodies  >2 publications with TNFRSF17 and Pharynx
 Connective Tissue Antibodies  >1 publications with TNFRSF17 and Connective Tissue
 Lung Antibodies  >1 publications with TNFRSF17 and Lung
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