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anti-BHMT antibody :: Mouse anti-Human BHMT Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246471
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BHMT, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 8C11H5] (IgG1) to Human BHMT

 Product Synonym Names    Anti-BHMT Antibody (clone 8C11H5) IHC-plus; BHMT; BHMT1; Human BHMT
 Product Gene Name   

anti-BHMT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602888
 3D Structure    ModBase 3D Structure for Q93088
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    8C11H5
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Human BHMT
 Purity/Purification    Ascites
 Form/Format    Ascites fluid, 0.03% sodium azide
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 Target Species    Human
 Immunogen Description    Purified recombinant human BHMT expressed in E Coli.
 Immunogen    BHMT antibody was raised against purified recombinant human BHMT expressed in E Coli.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-BHMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BHMT antibody

   Betaine-homocysteine methyltransferase is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in BHMT could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.
 Applications Tested/Suitable for anti-BHMT antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-BHMT antibody    ELISA, IHC-P (1:200), WB (1:500 - 1:2000)
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 Immunohistochemistry (IHC) of anti-BHMT antibody    Anti-BHMT antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
anti-BHMT antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BHMT antibody    Anti-BHMT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
anti-BHMT antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-BHMT antibody    Western blot of anti-BHMT monoclonal antibody against truncated Trx-BHMT recombinant protein(1)
anti-BHMT antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BHMT. It may not necessarily be applicable to this product.
 NCBI GI #    157266337
 NCBI GeneID    635
 NCBI Accession #    NP_001704.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001713.2 [Other Products]
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 UniProt Primary Accession #    Q93088 [Other Products]
 UniProt Secondary Accession #    Q9UNI9 [Other Products]
 UniProt Related Accession #    Q93088 [Other Products]
 Molecular Weight    44,998 Da
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 NCBI Official Full Name    betaine--homocysteine S-methyltransferase 1
 NCBI Official Synonym Full Names    betaine--homocysteine S-methyltransferase
 NCBI Official Symbol    BHMT [Similar Products]
 NCBI Official Synonym Symbols   
BHMT1; HEL-S-61p
[Similar Products]
 NCBI Protein Information    betaine--homocysteine S-methyltransferase 1; epididymis secretory sperm binding protein Li 61p
 UniProt Protein Name    Betaine--homocysteine S-methyltransferase 1
 Protein Family    Betaine--homocysteine S-methyltransferase
 UniProt Gene Name    BHMT [Similar Products]
 UniProt Entry Name    BHMT1_HUMAN
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 NCBI Summary for BHMT    This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BHMT    BHMT: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

Protein type: EC 2.1.1.5; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; Methyltransferase

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding; protein complex binding

Biological Process: S-methylmethionine cycle; protein amino acid methylation; betaine catabolic process; sulfur amino acid metabolic process; S-adenosylmethionine metabolic process; response to organic nitrogen; betaine metabolic process; regulation of homocysteine metabolic process
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 Research Articles on BHMT    1. Women harboring the single nucleotide polymorphism BHMT 742G>A have a decreased risk of a Down Syndrome pregnancy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BHMT antibodyPathways associated with anti-BHMT antibody
 Reference Product  PubMed Publications
 CBS antibody  >38 publications with BHMT and CBS
 AHCY antibody  >7 publications with BHMT and AHCY
 MAT1A antibody  >6 publications with BHMT and MAT1A
 MAT2A antibody  >5 publications with BHMT and MAT2A
 MAT2B antibody  >4 publications with BHMT and MAT2B
 CTH antibody  >2 publications with BHMT and CTH
 AHCYL1 antibody  >1 publications with BHMT and AHCYL1
 DMGDH antibody  >1 publications with BHMT and DMGDH
 Products by Pathway  Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 Sulfur Amino Acid Metabolism Pathway antibodies  Sulfur Amino Acid Metabolism Pathway Diagram
 Trans-sulfuration And One Carbon Metabolism Pathway antibodies  Trans-sulfuration And One Carbon Metabolism Pathway Diagram
Diseases associated with anti-BHMT antibodyOrgans/Tissues associated with anti-BHMT antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >31 publications with BHMT and Liver Diseases
 Cardiovascular Diseases Antibodies  >22 publications with BHMT and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >16 publications with BHMT and Nervous System Diseases
 Fatty Liver Antibodies  >14 publications with BHMT and Fatty Liver
 Liver Neoplasms Antibodies  >11 publications with BHMT and Liver Neoplasms
 Disease Models, Animal Antibodies  >10 publications with BHMT and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >10 publications with BHMT and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >8 publications with BHMT and Heart Diseases
 Kidney Diseases Antibodies  >7 publications with BHMT and Kidney Diseases
 Drug-Induced Liver Injury Antibodies  >7 publications with BHMT and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >120 publications with BHMT and Liver
 Kidney Antibodies  >27 publications with BHMT and Kidney
 Brain Antibodies  >8 publications with BHMT and Brain
 Intestine Antibodies  >3 publications with BHMT and Intestine
 Eye Antibodies  >3 publications with BHMT and Eye
 Embryonic Tissue Antibodies  >2 publications with BHMT and Embryonic Tissue
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