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anti-Kcnmb2 antibody :: Mouse BK Beta2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS804398
Unit / Price
0.1 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BK Beta2 (Kcnmb2), Monoclonal Antibody

 Also Known As   

BK Beta2 Antibody: ATTO 680

 Product Synonym Names    KCNMB2; Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Calcium-activated potassium channel; subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
 Product Gene Name   

anti-Kcnmb2 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: BK Beta2 Clone #S53-32 (MBS800649)
ATTO 680 Conjugated Antibody: BK Beta2 Clone #S53-32 (MBS804398)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9CZM9
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    S53-32
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    Protein G Purified
 Concentration    1mg/mL (lot specific)
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 Conjugate    ATTO 680
 Storage Buffer    PBS pH7.4, 50% glycerol, 0.09% sodium azide
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 Preparation and Storage    -20 degree C
 Other Notes    Small volumes of anti-Kcnmb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Kcnmb2 antibody

   Background Info: No cross-reactivity against BKBeta1, BKBeta3 or BKBeta4.

Scientific Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (4). This has major implications on other physiological processes in tissues other than the brain.
 Product Categories/Family for anti-Kcnmb2 antibody    Ion Channels, Neuroscience
 Applications Tested/Suitable for anti-Kcnmb2 antibody   

Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

 Application Notes for anti-Kcnmb2 antibody    1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)
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 Immunohistochemistry (IHC) of anti-Kcnmb2 antibody    Immunohistochemistry analysis using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower epidermal cells positive, but quite dull.
anti-Kcnmb2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-Kcnmb2 antibody    Western Blot analysis of Human Cell line lysates showing detection of BK Beta2 Potassium Channel protein using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.
anti-Kcnmb2 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry/Immunofluorescence (ICC/IF) of anti-Kcnmb2 antibody    Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20 degree C. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dottiness and dull.
anti-Kcnmb2 antibody Immunocytochemistry/Immunofluorescence (ICC/IF) (ICC) image
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NCBI/Uniprot data below describe general gene information for Kcnmb2. It may not necessarily be applicable to this product.
 NCBI GI #    21312300
 NCBI GeneID    72413
 NCBI Accession #    NP_082507.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_028231.2 [Other Products]
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 UniProt Primary Accession #    Q9CZM9 [Other Products]
 UniProt Related Accession #    Q9CZM9 [Other Products]
 Molecular Weight    27,120 Da [Similar Products]
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 NCBI Official Full Name    calcium-activated potassium channel subunit beta-2
 NCBI Official Synonym Full Names    potassium large conductance calcium-activated channel, subfamily M, beta member 2
 NCBI Official Symbol    Kcnmb2 [Similar Products]
 NCBI Official Synonym Symbols   
2700049B16Rik; 3110031N04Rik
[Similar Products]
 NCBI Protein Information    calcium-activated potassium channel subunit beta-2; BKbeta2; slo-beta-2; k(VCA)beta-2; BK channel subunit beta-2; maxi K channel subunit beta-2; charybdotoxin receptor subunit beta-2; calcium-activated potassium channel, subfamily M subunit beta-2
 UniProt Protein Name    Calcium-activated potassium channel subunit beta-2
 UniProt Synonym Protein Names   
BK channel subunit beta-2; BKbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
 Protein Family    Calcium-activated potassium channel
 UniProt Gene Name    Kcnmb2 [Similar Products]
 UniProt Synonym Gene Names    BKbeta2 [Similar Products]
 UniProt Entry Name    KCMB2_MOUSE
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 UniProt Comments for Kcnmb2    KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: voltage-gated potassium channel complex; membrane; integral to plasma membrane; integral to membrane

Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity; potassium channel activity

Biological Process: regulation of action potential; synaptic transmission; transport; generation of action potential; ion transport; detection of calcium ion; potassium ion transport
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Product References and Citations for anti-Kcnmb2 antibody

   1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1- 13. 4. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481- 1489.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Kcnmb2 antibodyDiseases associated with anti-Kcnmb2 antibody
 Products by Pathway  Pathway Diagram
 Ca2+ Activated K+ Channels Pathway antibodies  Ca2+ Activated K+ Channels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 CGMP Effects Pathway antibodies  CGMP Effects Pathway Diagram
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1 publications with Kcnmb2 and Fibrosis
Organs/Tissues associated with anti-Kcnmb2 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with Kcnmb2 and Eye
 Brain Antibodies  >1 publications with Kcnmb2 and Brain
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