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anti-BMPR1B antibody :: Mouse anti-Human BMPR1B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS633576 anti-BMPR1B antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BMPR1B, Monoclonal Antibody

 Also Known As   

BMPR1B (Bone Morphogenetic Protein Receptor Type-1B, BMP Type-1B Receptor, BMPR-1B, CDw293)

 Product Synonym Names    Anti -BMPR1B (Bone Morphogenetic Protein Receptor Type-1B, BMP Type-1B Receptor, BMPR-1B, CDw293)
 Product Gene Name   

anti-BMPR1B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (95679128..96079601). Location: 4q22-q24
 OMIM    112600
 3D Structure    ModBase 3D Structure for O00238
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    2F3
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human BMPR1B.
 Purity/Purification    Purified
Purified.
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    BMPR1B (AAH47773, 14-503aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-BMPR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BMPR1B antibody

   The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55kD and type II receptors of about 70-80kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
 Product Categories/Family for anti-BMPR1B antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-BMPR1B antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-BMPR1B antibody    Suitable for use in ELISA and Western Blot.
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NCBI/Uniprot data below describe general gene information for BMPR1B. It may not necessarily be applicable to this product.
 NCBI GI #    4502431
 NCBI GeneID    658
 NCBI Accession #    NP_001194.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001203.2 [Other Products]
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 UniProt Primary Accession #    O00238 [Other Products]
 UniProt Secondary Accession #    P78366; B2R953 [Other Products]
 UniProt Related Accession #    O00238 [Other Products]
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 NCBI Official Full Name    bone morphogenetic protein receptor type-1B
 NCBI Official Synonym Full Names    bone morphogenetic protein receptor, type IB
 NCBI Official Symbol    BMPR1B [Similar Products]
 NCBI Official Synonym Symbols   
ALK6; ALK-6; CDw293
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein receptor type-1B; BMPR-1B; OTTHUMP00000161621; OTTHUMP00000161622; OTTHUMP00000219359; OTTHUMP00000219880; OTTHUMP00000219882; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase
 UniProt Protein Name    Bone morphogenetic protein receptor type-1B
 Protein Family    Bone morphogenetic protein receptor
 UniProt Entry Name    BMR1B_HUMAN
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 NCBI Summary for BMPR1B    This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq]
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 UniProt Comments for BMPR1B    BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; EC 2.7.11.30; Kinase, protein; Membrane protein, integral; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22-q24

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: chondrocyte development; positive regulation of bone mineralization; limb morphogenesis; protein amino acid phosphorylation; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; eye development; dorsal/ventral pattern formation; retina development in camera-type eye; proteoglycan biosynthetic process; ovarian cumulus expansion; positive regulation of cell differentiation; inflammatory response; skeletal development; cartilage condensation; retinal ganglion cell axon guidance

Disease: Chondrodysplasia, Acromesomelic, With Genital Anomalies; Brachydactyly, Type A2
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 Research Articles on BMPR1B    1. BMPR1B were detected in the human retina and retinoblastoma cell lines.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BMPR1B antibodyPathways associated with anti-BMPR1B antibody
 Reference Product  PubMed Publications
 BMPR1A antibody  >137 publications with BMPR1B and BMPR1A
 BMPR2 antibody  >72 publications with BMPR1B and BMPR2
 BMP2 antibody  >41 publications with BMPR1B and BMP2
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-BMPR1B antibodyOrgans/Tissues associated with anti-BMPR1B antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >21 publications with BMPR1B and Neoplasms
 Congenital Abnormalities Antibodies  >14 publications with BMPR1B and Congenital Abnormalities
 Bone Diseases, Developmental Antibodies  >7 publications with BMPR1B and Bone Diseases, Developmental
 Limb Deformities, Congenital Antibodies  >7 publications with BMPR1B and Limb Deformities, Congenital
 Brachydactyly type A2 Antibodies  >6 publications with BMPR1B and Brachydactyly type A2
 Craniofacial Abnormalities Antibodies  >5 publications with BMPR1B and Craniofacial Abnormalities
 Carcinoma Antibodies  >5 publications with BMPR1B and Carcinoma
 Lung Diseases Antibodies  >4 publications with BMPR1B and Lung Diseases
 Breast Neoplasms Antibodies  >4 publications with BMPR1B and Breast Neoplasms
 Intestinal Diseases Antibodies  >4 publications with BMPR1B and Intestinal Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >151 publications with BMPR1B and Bone
 Embryonic Tissue Antibodies  >16 publications with BMPR1B and Embryonic Tissue
 Ovary Antibodies  >15 publications with BMPR1B and Ovary
 Brain Antibodies  >13 publications with BMPR1B and Brain
 Muscle Antibodies  >10 publications with BMPR1B and Muscle
 Connective Tissue Antibodies  >9 publications with BMPR1B and Connective Tissue
 Eye Antibodies  >8 publications with BMPR1B and Eye
 Nerve Antibodies  >8 publications with BMPR1B and Nerve
 Vascular Antibodies  >7 publications with BMPR1B and Vascular
 Lung Antibodies  >7 publications with BMPR1B and Lung
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