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anti-BORIS antibody :: Rat BORIS Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS532845 anti-BORIS antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BORIS, Monoclonal Antibody

★Popular Item★
 Also Known As   

BORIS antibody

 Product Synonym Names    Monoclonal BORIS; Anti-BORIS; Brother of the Regulator of Imprinted Sites
 Product Gene Name   

anti-BORIS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607022
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    KT72
 Host    Rat
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 Specificity    Mouse
 Purity/Purification    BORIS antibody was purified by Protein G chromatography.
 Form/Format    Supplied in PBS containing 0.1% sodium azide as a preservative
 Concentration    1 mg/ml (lot specific)
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 Biological Significance    BORIS is a novel male germ-line-specific protein associated with epigenetic reprogramming events.
 Biohazard Information    This product contains sodium azide which is hazardous
 Immunogen    BORIS antibody was raised in Rat using Mouse BORIS as the immunogen.
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 Preparation and Storage    Store at 4 degree C for up to 1 month. For long term storage, aliquot and store at -20 to -80 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-BORIS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BORIS antibody

   Rat monoclonal BORIS antibody
 Product Categories/Family for anti-BORIS antibody    DNA & RNA
 Applications Tested/Suitable for anti-BORIS antibody   

Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-BORIS antibody    IF: 1-10 ug/ml
WB: 0.1-1 ug/ml
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NCBI/Uniprot data below describe general gene information for BORIS. It may not necessarily be applicable to this product.
 NCBI GI #    82882230
 NCBI Accession #    ABB92839.1 [Other Products]
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 UniProt Secondary Accession #    A0S6W1; A1L4C6; A6XGL8; A6XGM2; A6XGM3; A6XGM8; A6XGN0; A6XGN1; A6XGN2; A6XGN3; A6XGN4 [Other Products]
 Molecular Weight    35,417 Da
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 NCBI Official Full Name    BORIS-like protein
 UniProt Protein Name    Transcriptional repressor CTCFL
 UniProt Synonym Protein Names   
Brother of the regulator of imprinted sites; CCCTC-binding factor; CTCF paralog; CTCF-like protein; Cancer/testis antigen 27; CT27; Zinc finger protein CTCF-T
 UniProt Gene Name    CTCFL [Similar Products]
 UniProt Synonym Gene Names    BORIS; CT27 [Similar Products]
 UniProt Entry Name    CTCFL_HUMAN
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 UniProt Comments for BORIS    BORIS: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3. Testis specific. Specifically expressed in primary spermatocytes. Belongs to the CTCF zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; histone binding; sequence-specific DNA binding; metal ion binding

Biological Process: histone methylation; genetic imprinting; transcription, DNA-dependent; DNA methylation during gametogenesis; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of histone H3-K4 methylation; cell cycle
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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