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anti-BRCA1 antibody :: Mouse BRCA1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190077 anti-BRCA1 antibody
Unit / Price
0.1 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BRCA1, Monoclonal Antibody

★Popular Item★
 Also Known As   

BRCA1 Monoclonal Antibody

 Product Synonym Names    Anti-BRCA1; BRCA1
 Product Gene Name   

anti-BRCA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (41196312..41277500, complement). Location: 17q21
 OMIM    113705
 3D Structure    ModBase 3D Structure for P38398
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 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Host    Mouse
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 Specificity    Anti-BRCA1 [Murine MAb recognizes full-length BRCA1, a 220 kDa nuclear phosphoprotein.]
This antibody recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation.
 Form/Format    100 ug Protein G purified antibody in PBS, pH 7.4
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 Antigen    GST fusion protein expressedin E. coli corresponding to aa 341-748of full-length BRCA1.
 Stabilizer    None
 Preservatives    None. Available on request.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.
 Other Notes    Small volumes of anti-BRCA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-BRCA1 antibody    Cancer Research Products
 Applications Tested/Suitable for anti-BRCA1 antibody   

Immunoblot, Immunoprecipitation

 Application Notes for anti-BRCA1 antibody    Immunoblotting: use at 1-10 ug/ml.
Immunoprecipitation: use at 1-10 ug/ml.
Positive controls: Any normal human tissue, especially those containing rapidly proliferating cells, such aslymphoid germinal centers.
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NCBI/Uniprot data below describe general gene information for BRCA1. It may not necessarily be applicable to this product.
 NCBI GI #    1698399
 NCBI GeneID    672
 NCBI Accession #    AAC37594.1 [Other Products]
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 UniProt Primary Accession #    P38398 [Other Products]
 UniProt Secondary Accession #    O15129; Q3LRJ0; Q7KYU9 [Other Products]
 UniProt Related Accession #    P38398; Q05BZ9; Q1RMC1; Q3B890; Q3B891; Q3LRH8; Q3LRJ6; Q3YB49; Q3YB50; Q3YB52 [Other Products]
 Molecular Weight    207,721 Da [Similar Products]
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 NCBI Official Full Name    BRCA1
 NCBI Official Synonym Full Names    breast cancer 1, early onset
 NCBI Official Symbol    BRCA1 [Similar Products]
 NCBI Official Synonym Symbols   
IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1
[Similar Products]
 NCBI Protein Information    breast cancer type 1 susceptibility protein; OTTHUMP00000212143; OTTHUMP00000212147; OTTHUMP00000212148; OTTHUMP00000212149; OTTHUMP00000212150; OTTHUMP00000212151; OTTHUMP00000212155; RING finger protein 53; BRCA1/BRCA2-containing complex, subunit 1; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein
 UniProt Protein Name    Breast cancer type 1 susceptibility protein
 UniProt Synonym Protein Names   
RING finger protein 53
 Protein Family    BRCA1-A complex
 UniProt Gene Name    BRCA1 [Similar Products]
 UniProt Synonym Gene Names    RNF53 [Similar Products]
 UniProt Entry Name    BRCA1_HUMAN
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 NCBI Summary for BRCA1    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq]
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 UniProt Comments for BRCA1    BRCA1: the BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACC1 and preventing its dephosphorylation. Defects in BRCA1 are a cause of genetic susceptibility to breast cancer. Mutations in BRCA1 are thought to be responsible for more than 80% of inherited breast-ovarian cancer. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association may be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts (via BRCT domains) with CTIP. Associates with RNA polymerase II holoenzyme. Interacts with SMC1 and COBRA1. Interacts (via BRCT domains) with BRIP1. Interacts with FANCD2 (ubiquitinated). Interacts with BAP1. Interacts with Artemis and claspin. Interacts with H2AFX (phosphorylated on S140). Interacts with CHK1. Interacts with BRCC3. Five human isoforms are produced by alternative splicing and alternative initiation. Isoform 1 and isoform 3 are widely expressed. Isoform 1 is largely nuclear, while isoforms 3 and 5 are cytoplasmic.

Protein type: Nuclear receptor co-regulator; Tumor suppressor; Transcription, coactivator/corepressor; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; gamma-tubulin ring complex; protein complex; condensed nuclear chromosome; BRCA1-BARD1 complex; cytoplasm; plasma membrane; chromosome; ribonucleoprotein complex; nucleus; ubiquitin ligase complex

Molecular Function: tubulin binding; protein binding; enzyme binding; androgen receptor binding; DNA binding; zinc ion binding; RNA binding; ubiquitin protein ligase binding; transcription coactivator activity; ubiquitin-protein ligase activity; damaged DNA binding; ligase activity

Biological Process: genetic imprinting; apoptosis; positive regulation of transcription, DNA-dependent; dosage compensation, by inactivation of X chromosome; centrosome cycle; protein ubiquitination; negative regulation of histone H3-K4 methylation; positive regulation of histone H3-K4 methylation; chromosome segregation; negative regulation of histone acetylation; regulation of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; DNA replication; negative regulation of fatty acid biosynthetic process; fatty acid biosynthetic process; positive regulation of histone H3-K9 methylation; negative regulation of histone H3-K9 methylation; protein autoubiquitination; chordate embryonic development; positive regulation of DNA repair; postreplication repair; DNA repair; negative regulation of centriole replication; double-strand break repair via homologous recombination; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of angiogenesis; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of transcription from RNA polymerase III promoter; positive regulation of protein ubiquitination; response to estrogen stimulus; androgen receptor signaling pathway; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; response to ionizing radiation; negative regulation of transcription, DNA-dependent; G2/M transition DNA damage checkpoint; response to DNA damage stimulus

Disease: Breast-ovarian Cancer, Familial, Susceptibility To, 1; Pancreatic Cancer, Susceptibility To, 4; Breast Cancer
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Product References and Citations for anti-BRCA1 antibody

   Chen, Y et al. (1995) Science 270: 789-791; Chen, C-F et al. (1995) J Biol Chem 271: 32863-32868; Chen, Y et al. (1996) Cancer Res 56: 3168-3172.
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 Research Articles on BRCA1    1. BRCA1 germline mutations are associated with uterine serous carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BRCA1 antibodyPathways associated with anti-BRCA1 antibody
 Reference Product  PubMed Publications
 BRCA2 antibody  >4605 publications with BRCA1 and BRCA2
 RAD51 antibody  >292 publications with BRCA1 and RAD51
 TP53 antibody  >283 publications with BRCA1 and TP53
 FANCA antibody  >222 publications with BRCA1 and FANCA
 BARD1 antibody  >210 publications with BRCA1 and BARD1
 ATR antibody  >145 publications with BRCA1 and ATR
 CHEK2 antibody  >129 publications with BRCA1 and CHEK2
 MLH1 antibody  >115 publications with BRCA1 and MLH1
 MYC antibody  >112 publications with BRCA1 and MYC
 FANCD2 antibody  >107 publications with BRCA1 and FANCD2
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 ATM Mediated Phosphorylation Of Repair Proteins Pathway antibodies  ATM Mediated Phosphorylation Of Repair Proteins Pathway Diagram
 ATM Mediated Response To DNA Double-strand Break Pathway antibodies  ATM Mediated Response To DNA Double-strand Break Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
Diseases associated with anti-BRCA1 antibodyOrgans/Tissues associated with anti-BRCA1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6349 publications with BRCA1 and Neoplasms
 Breast Neoplasms Antibodies  >5410 publications with BRCA1 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >2889 publications with BRCA1 and Ovarian Neoplasms
 Carcinoma Antibodies  >1091 publications with BRCA1 and Carcinoma
 Adenocarcinoma Antibodies  >446 publications with BRCA1 and Adenocarcinoma
 Death Antibodies  >284 publications with BRCA1 and Death
 Colorectal Neoplasms Antibodies  >223 publications with BRCA1 and Colorectal Neoplasms
 Anemia Antibodies  >208 publications with BRCA1 and Anemia
 Recurrence Antibodies  >179 publications with BRCA1 and Recurrence
 Prostatic Neoplasms Antibodies  >158 publications with BRCA1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >480 publications with BRCA1 and Blood
 Ovary Antibodies  >228 publications with BRCA1 and Ovary
 Prostate Antibodies  >221 publications with BRCA1 and Prostate
 Lung Antibodies  >138 publications with BRCA1 and Lung
 Mammary Gland Antibodies  >136 publications with BRCA1 and Mammary Gland
 Lymph Antibodies  >123 publications with BRCA1 and Lymph
 Lymph Node Antibodies  >122 publications with BRCA1 and Lymph Node
 Bone Antibodies  >80 publications with BRCA1 and Bone
 Kidney Antibodies  >72 publications with BRCA1 and Kidney
 Brain Antibodies  >71 publications with BRCA1 and Brain
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