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anti-BSG antibody :: Mouse anti-Human Basigin / Emmprin / CD147 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245487
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Basigin / Emmprin / CD147 (BSG), Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone MEM-M6/1] (IgG1) to Human Basigin / Emmprin / CD147

 Product Synonym Names    Anti-Basigin / Emmprin / CD147 Antibody (clone MEM-M6/1) IHC-plus; BSG; 5F7; Basigin; Basigin (Ok blood group); CD147 antigen; Collagenase stimulatory factor; EMMPRIN; OK; OK blood group antigen; TCSF; CD147; M6; Emmprin; Human Basigin; Emmprin; CD147
 Product Gene Name   

anti-BSG antibody

[Similar Products]
 Product Synonym Gene Name    CD147 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 111380
 3D Structure    ModBase 3D Structure for P35613
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MEM-M6/1
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.4, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    recombinant CD147Rg consisting of the cDNA coding for the hinge region CH2 and CH3 domain of human IgG1.
 Immunogen Type    Recombinant protein
 Immunogen    Basigin / Emmprin / CD147 antibody was raised against recombinant CD147Rg consisting of the cDNA coding for the hinge region CH2 and CH3 domain of human IgG1.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-BSG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BSG antibody

   CD147 (BSG) is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
 Applications Tested/Suitable for anti-BSG antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

 Application Notes for anti-BSG antibody    Flo (1:50 - 1:100), IHC-P (10 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-BSG antibody    Anti-CD147 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-BSG antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BSG antibody    Anti-CD147 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-BSG antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BSG antibody    Anti-CD147 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-BSG antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-BSG antibody    Staining of red blood cells
anti-BSG antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for BSG. It may not necessarily be applicable to this product.
 NCBI GI #    38372919
 NCBI GeneID    682
 NCBI Accession #    NP_001719.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001728.3 [Other Products]
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 UniProt Primary Accession #    P35613 [Other Products]
 UniProt Secondary Accession #    Q7Z796; Q8IZL7; A6NJW1; D3YLG5 [Other Products]
 UniProt Related Accession #    P35613 [Other Products]
 Molecular Weight    22,764 Da
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 NCBI Official Full Name    basigin isoform 1
 NCBI Official Synonym Full Names    basigin (Ok blood group)
 NCBI Official Symbol    BSG [Similar Products]
 NCBI Official Synonym Symbols   
M6; OK; 5F7; TCSF; CD147; EMMPRIN
[Similar Products]
 NCBI Protein Information    basigin; CD147 antigen; OK blood group antigen; collagenase stimulatory factor; leukocyte activation antigen M6; extracellular matrix metalloproteinase inducer; tumor cell-derived collagenase stimulatory factor
 UniProt Protein Name    Basigin
 UniProt Synonym Protein Names   
5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; CD_antigen: CD147
 Protein Family    Basigin
 UniProt Gene Name    BSG [Similar Products]
 UniProt Synonym Gene Names    EMMPRIN; TCSF [Similar Products]
 UniProt Entry Name    BASI_HUMAN
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 NCBI Summary for BSG    The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BSG    BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: Golgi membrane; focal adhesion; mitochondrion; membrane; integral to plasma membrane; melanosome; plasma membrane; sarcolemma; acrosomal membrane; lipid raft

Molecular Function: mannose binding; protein binding

Biological Process: response to peptide hormone stimulus; extracellular matrix organization and biogenesis; response to cAMP; decidualization; odontogenesis of dentine-containing teeth; response to mercury ion; cellular metabolic process; extracellular matrix disassembly; cell surface receptor linked signal transduction; blood coagulation; pyruvate metabolic process; leukocyte migration; embryo implantation

Disease: Blood Group--ok
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 Research Articles on BSG    1. High expression of CD147 is associated with drug resistance in ovarian cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BSG antibodyPathways associated with anti-BSG antibody
 Reference Product  PubMed Publications
 SLC16A4 antibody  >17 publications with BSG and SLC16A4
 MMP1 antibody  >5 publications with BSG and MMP1
 SLC16A3 antibody  >4 publications with BSG and SLC16A3
 CAV1 antibody  >3 publications with BSG and CAV1
 AJAP1 antibody  >1 publications with BSG and AJAP1
 SLC16A8 antibody  >1 publications with BSG and SLC16A8
 PPIL2 antibody  >1 publications with BSG and PPIL2
 SLC16A1 antibody  >1 publications with BSG and SLC16A1
 Products by Pathway  Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway antibodies  Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway Diagram
Diseases associated with anti-BSG antibodyOrgans/Tissues associated with anti-BSG antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >154 publications with BSG and Carcinoma
 Neoplasm Metastasis Antibodies  >84 publications with BSG and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >72 publications with BSG and Adenocarcinoma
 Neoplasm Invasiveness Antibodies  >70 publications with BSG and Neoplasm Invasiveness
 Inflammation Antibodies  >47 publications with BSG and Inflammation
 Breast Neoplasms Antibodies  >40 publications with BSG and Breast Neoplasms
 Liver Diseases Antibodies  >37 publications with BSG and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >33 publications with BSG and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >30 publications with BSG and Liver Neoplasms
 Necrosis Antibodies  >28 publications with BSG and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >353 publications with BSG and Blood
 Brain Antibodies  >184 publications with BSG and Brain
 Vascular Antibodies  >98 publications with BSG and Vascular
 Muscle Antibodies  >57 publications with BSG and Muscle
 Lung Antibodies  >51 publications with BSG and Lung
 Nerve Antibodies  >51 publications with BSG and Nerve
 Liver Antibodies  >50 publications with BSG and Liver
 Eye Antibodies  >41 publications with BSG and Eye
 Lymph Antibodies  >38 publications with BSG and Lymph
 Lymph Node Antibodies  >37 publications with BSG and Lymph Node
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