P20749.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
47,584 Da
NCBI Official Full Name
B-cell lymphoma 3 protein
NCBI Official Synonym Full Names
B-cell CLL/lymphoma 3
NCBI Official Synonym Symbols
NCBI Protein Information
B-cell lymphoma 3 protein; BCL-3; proto-oncogene BCL3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3-encoded protein; chronic lymphatic leukemia protein
UniProt Protein Name
B-cell lymphoma 3 protein
UniProt Synonym Protein Names
Proto-oncogene BCL3
UniProt Synonym Gene Names
UniProt Entry Name
BCL3_HUMAN
NCBI Summary for Bcl-3
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
UniProt Comments for Bcl-3
Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation
By similarity. Ref.4
Subunit structure: Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD
By similarity. Ref.4 Ref.5 Ref.6 Ref.7
Subcellular location: Nucleus. Cytoplasm
By similarity. Cytoplasm › perinuclear region
By similarity. Note: Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation
By similarity.
Post-translational modification: Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation
By similarity.Activated by phosphorylation.
Involvement in disease: A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
Sequence similarities: Contains 7 ANK repeats.
Caution: It is uncertain whether Met-1 or Met-9 is the initiator.
Sequence caution: The sequence AAA51815.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA51816.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH64993.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on Bcl-3
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Pathways associated with anti-Bcl-3 antibody
Diseases associated with anti-Bcl-3 antibody
Organs/Tissues associated with anti-Bcl-3 antibody
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