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anti-BECN1 antibody :: Beclin 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS475123
Western Blot (WB)
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Beclin 1 (BECN1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Beclin 1 Mouse mAb

 Product Synonym Names    APG6; ATG 6; ATG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; Beclin 1 (coiled coil moesin like BCL2 interacting protein); Beclin 1 autophagy related; Beclin-1; Beclin1; BECN 1; BECN1; BECN1_HUMAN; Coiled coil myosin like BCL2 interacting protein; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS 30; VPS30
 Product Gene Name   

anti-BECN1 antibody

[Similar Products]
 Product Synonym Gene Name    ATG6; VPS30; beclin1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF077301 mRNA
 3D Structure    ModBase 3D Structure for Q14457
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4F4-B10-C9
 Host    Mouse
Source: Human
 Species Reactivity    Human, Mouse, Rat, Monkey, Hamster
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 Purity/Purification    Affinity Purified
 Form/Format    Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol
 Concentration    1mg/ml (lot specific)
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 Immunogen    Purified recombinant human Beclin 1 protein fragments expressed in E Coli.
 Sensitivity    This antibody detects endogenous levels of Beclin 1 and does not cross-react with related proteins.
 Sequence Similarities    Belongs to the beclin family.
 Subunit Structure    Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 upregulates autophagy, while the one containing Rubicon downregulates autophagy By similarity. Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB By similarity. Interacts with DAPK1.
 Subcellular Location    Golgi apparatus; trans-Golgi network membrane; Peripheral membrane protein.
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 Other Notes    Small volumes of anti-BECN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BECN1 antibody

   Entrez Summary: Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).
UniPort Summary Function: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
 Product Categories/Family for anti-BECN1 antibody    Metabolism; Pathways and Processes; Metabolism processes; Autophagy and mitophagy; Cancer; Signal transduction; Autophagy; Microbiology; Interspecies Interaction; Host Immune Response
 Applications Tested/Suitable for anti-BECN1 antibody   

Western Blot (WB)

 Application Notes for anti-BECN1 antibody    WB: 1:1000
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 Western Blot (WB) of anti-BECN1 antibody    Western blot detection of Beclin 1 in Hela, 3T3, C6, COS7, CHO-K1, Rat brain and Jurkat cell lysates using Beclin 1 mouse mAb (1:1000 diluted).Predicted band size:52KDa.Observed band size:55KDa.
anti-BECN1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BECN1. It may not necessarily be applicable to this product.
 NCBI GI #    929524267
 NCBI GeneID    8678
 NCBI Accession #    NP_001300927.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003766.3 [Other Products]
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 UniProt Primary Accession #    Q14457 [Other Products]
 UniProt Secondary Accession #    O75595; Q9UNA8; B2R6N7 [Other Products]
 UniProt Related Accession #    Q14457 [Other Products]
 Molecular Weight    55
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 NCBI Official Full Name    beclin-1 isoform a
 NCBI Official Synonym Full Names    beclin 1
 NCBI Official Symbol    BECN1 [Similar Products]
 NCBI Official Synonym Symbols   
ATG6; VPS30; beclin1
[Similar Products]
 NCBI Protein Information    beclin-1
 UniProt Protein Name    Beclin-1
 UniProt Synonym Protein Names   
Coiled-coil myosin-like BCL2-interacting protein; Protein GT197
 Protein Family    Beclin
 UniProt Gene Name    BECN1 [Similar Products]
 UniProt Synonym Gene Names    GT197 [Similar Products]
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 NCBI Summary for BECN1    This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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 UniProt Comments for BECN1    beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Protein type: Adaptor/scaffold; Autophagy; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: cytosol; endoplasmic reticulum; endosome; extrinsic to membrane; mitochondrion

Molecular Function: phosphoinositide 3-kinase binding; protein binding; ubiquitin protein ligase binding

Biological Process: autophagic vacuole formation; autophagy; cellular defense response; cellular response to glucose starvation; cellular response to nitrogen starvation; CVT pathway; cytokinesis; late endosome to vacuole transport; macroautophagy; mitotic metaphase plate congression; positive regulation of autophagy; receptor catabolic process; regulation of cytokinesis
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 Research Articles on BECN1    1. Both Beclin-1 and HIF-1alpha could be considered as important biomarkers determinants of pathogenesis and survival in acute leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BECN1 antibodyPathways associated with anti-BECN1 antibody
 Reference Product  PubMed Publications
 BCL2 antibody  >87 publications with BECN1 and BCL2
 BCL2L1 antibody  >69 publications with BECN1 and BCL2L1
 UVRAG antibody  >54 publications with BECN1 and UVRAG
 ATG14 antibody  >49 publications with BECN1 and ATG14
 PIK3C3 antibody  >39 publications with BECN1 and PIK3C3
 AMBRA1 antibody  >32 publications with BECN1 and AMBRA1
 PARK2 antibody  >26 publications with BECN1 and PARK2
 MCL1 antibody  >18 publications with BECN1 and MCL1
 PIK3R4 antibody  >14 publications with BECN1 and PIK3R4
 Products by Pathway  Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Autophagy Pathway antibodies  Autophagy Pathway Diagram
 Autophagy Pathway antibodies  Autophagy Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Deubiquitination Pathway antibodies  Deubiquitination Pathway Diagram
 Macroautophagy Pathway antibodies  Macroautophagy Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Nanoparticle Triggered Autophagic Cell Death Pathway antibodies  Nanoparticle Triggered Autophagic Cell Death Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with anti-BECN1 antibodyOrgans/Tissues associated with anti-BECN1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >201 publications with BECN1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >142 publications with BECN1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >122 publications with BECN1 and Disease Models, Animal
 Necrosis Antibodies  >107 publications with BECN1 and Necrosis
 Inflammation Antibodies  >81 publications with BECN1 and Inflammation
 Liver Diseases Antibodies  >81 publications with BECN1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >69 publications with BECN1 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >62 publications with BECN1 and Heart Diseases
 Lung Neoplasms Antibodies  >47 publications with BECN1 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >47 publications with BECN1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >205 publications with BECN1 and Brain
 Blood Antibodies  >142 publications with BECN1 and Blood
 Liver Antibodies  >124 publications with BECN1 and Liver
 Muscle Antibodies  >119 publications with BECN1 and Muscle
 Heart Antibodies  >104 publications with BECN1 and Heart
 Lung Antibodies  >93 publications with BECN1 and Lung
 Vascular Antibodies  >73 publications with BECN1 and Vascular
 Nerve Antibodies  >50 publications with BECN1 and Nerve
 Kidney Antibodies  >47 publications with BECN1 and Kidney
 Bone Antibodies  >38 publications with BECN1 and Bone
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