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anti-B2M antibody :: Mouse Beta 2 Microglobulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS592082
Western Blot
Unit / Price
0.5 mg  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Beta 2 Microglobulin (B2M), Monoclonal Antibody

 Also Known As   

mAb anti-Human Beta 2 Microglobulin

 Product Synonym Names    Beta 2 Microglobulin; Mouse monoclonal antibody to human beta 2 microglobulin (B2MG)
 Product Gene Name   

anti-B2M antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109700
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    D6D1
 Host    Mouse
 Species Reactivity    Human. Others not tested
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 Specificity    Beta 2 Microglobulin
 Purity/Purification    Protein G affinity purified
 Form/Format    Lyophilized from a solution in 0.01M PBS, pH 7.2
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 Target Protein    Human beta 2 microglobulin
 Immunogen    Recombinant human beta 2 microglobulin
 Myeloma    Sp2/0-Ag14
 Light Chain    Kappa
 Reconstitution    Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
 Research Area    Renal disease, plasma cell cancer
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-B2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-B2M antibody

   Mouse monoclonal antibody to Human Beta 2 MG, Protein G affinity purified. Human beta 2 microglobulin (B2MG) is a component of major histocompatibility complex 1 (MHC1). It is abundant at the surface of lymphocytes and exists at the surface of all cell types except red cells. B2MG is normally filtered out of blood through glomeruli, but the process is impaired in patients with renal diseases. Elevated B2MG level is implicated with lymphoma, multiple myeloma, renal diseases, viral infections and auto-immune conditions.
 Product Categories/Family for anti-B2M antibody    Primary antibody; Monoclonal Antibodies to Human Inflammatory Proteins
 Applications Tested/Suitable for anti-B2M antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-B2M antibody    ELISA: The antibody reacts with human B2MG.
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 Western Blot of anti-B2M antibody    Detect recombinant human B2MG antigen (100ng/lane) using antihuman B2MG mAb D6D1 at 1ug/mL dilution.
anti-B2M antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for B2M. It may not necessarily be applicable to this product.
 NCBI GI #    4757826
 NCBI GeneID    567
 NCBI Accession #    NP_004039.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004048.2 [Other Products]
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 UniProt Secondary Accession #    P01884; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4 [Other Products]
 UniProt Related Accession #    P61769 [Other Products]
 Molecular Weight    13,715 Da [Similar Products]
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 NCBI Official Full Name    beta-2-microglobulin
 NCBI Official Synonym Full Names    beta-2-microglobulin
 NCBI Official Symbol    B2M [Similar Products]
 NCBI Protein Information    beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin
 UniProt Protein Name    Beta-2-microglobulin
 Protein Family    Beta-2-microglobulin
 UniProt Gene Name    B2M [Similar Products]
 UniProt Entry Name    B2MG_HUMAN
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 NCBI Summary for B2M    This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
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 UniProt Comments for B2M    B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: Golgi apparatus; extracellular space; focal adhesion; endoplasmic reticulum lumen; extracellular region; Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; cytoplasm; plasma membrane; MHC class I protein complex; external side of plasma membrane

Molecular Function: identical protein binding; protein binding

Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; response to molecule of bacterial origin; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Disease: Hypoproteinemia, Hypercatabolic
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 Research Articles on B2M    1. results suggest that serum beta2M and GGT levels are useful indicators for evaluating the occurrence of slight inflammation as background, which promotes atherosclerosis even in healthy children.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to mAb anti-Human Beta 2 Microglobulin
 Catalog #  Product Name  Catalog #  Product Name
 MBS375121  Mouse Anti-Beta 2 Microglobulin [B1]  MBS240614  Rabbit Polyclonal to Human B2M / Beta 2 Microglobulin
 MBS682136  Human Beta 2 Microglobulin (r beta 2M (human))  MBS245109  Mouse Monoclonal [clone B2M-02] (IgG1) to Human B2M / Beta 2 Microglobulin
 MBS534219  beta 2 Microglobulin antibody  MBS212290  MOUSE ANTI RAT BETA 2 MICROGLOBULIN
 MBS219582  MOUSE ANTI HUMAN BETA 2 MICROGLOBULIN:HRP  MBS592280  mAb anti-Human Beta 2 Microglobulin
 MBS143949  Recombinant Human Beta 2 Microglobulin, His Tag  MBS534311  beta 2 Microglobulin antibody (biotin)
Products associated with anti-B2M antibodyPathways associated with anti-B2M antibody
 Reference Product  PubMed Publications
 HLA-A antibody  >16 publications with B2M and HLA-A
 TFRC antibody  >12 publications with B2M and TFRC
 HFE antibody  >3 publications with B2M and HFE
 LILRB1 antibody  >1 publications with B2M and LILRB1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with anti-B2M antibodyOrgans/Tissues associated with anti-B2M antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >82 publications with B2M and Cardiovascular Diseases
 Kidney Diseases Antibodies  >70 publications with B2M and Kidney Diseases
 Inflammation Antibodies  >40 publications with B2M and Inflammation
 Disease Models, Animal Antibodies  >30 publications with B2M and Disease Models, Animal
 Renal Insufficiency Antibodies  >28 publications with B2M and Renal Insufficiency
 Proteinuria Antibodies  >25 publications with B2M and Proteinuria
 Liver Diseases Antibodies  >21 publications with B2M and Liver Diseases
 Necrosis Antibodies  >20 publications with B2M and Necrosis
 Autoimmune Diseases Antibodies  >19 publications with B2M and Autoimmune Diseases
 Adenocarcinoma Antibodies  >19 publications with B2M and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >277 publications with B2M and Blood
 Kidney Antibodies  >110 publications with B2M and Kidney
 Bone Antibodies  >76 publications with B2M and Bone
 Bone Marrow Antibodies  >59 publications with B2M and Bone Marrow
 Liver Antibodies  >41 publications with B2M and Liver
 Heart Antibodies  >32 publications with B2M and Heart
 Skin Antibodies  >30 publications with B2M and Skin
 Muscle Antibodies  >29 publications with B2M and Muscle
 Brain Antibodies  >28 publications with B2M and Brain
 Vascular Antibodies  >24 publications with B2M and Vascular
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