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anti-Bmi1 antibody :: Mouse anti-Human Bmi1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850829
Testing Data
Unit / Price
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bmi1, Monoclonal Antibody

 Also Known As   

Bmi1 Antibody

 Product Gene Name   

anti-Bmi1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164831
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein G-Sepharose affinity purified
 Form/Format    Liquid
 Concentration    50ug/50ul (lot specific)
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 Relevance    The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.
 Perservative    0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
 Immunogen    Synthetic peptide from the N-terminal region of human Bmi1, conjugated to KLH.
 Cellular Localization    Nucleus
 Pathway    telomerase activity
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of anti-Bmi1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Bmi1 antibody

   Background: Mouse monoclonal IgG to Bmi1
 Product Categories/Family for anti-Bmi1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-Bmi1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-Bmi1 antibody    ELISA: 1/5000 - 1/20000, WB: 1/100-1/2000
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 Testing Data of anti-Bmi1 antibody    Bmi1 antibody at 1/500 dilution. Hela whole cell lysate at 40ug/Lane. Predicted band size: 37Kda. Observed band size: 37Kda.
anti-Bmi1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Bmi1. It may not necessarily be applicable to this product.
 NCBI GI #    39725706
 NCBI GeneID    648
 NCBI Accession #    NP_005171.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_005180.5 [Other Products]
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 UniProt Secondary Accession #    Q16030; Q5T8Z3; Q96F37 [Other Products]
 UniProt Related Accession #    P35226 [Other Products]
 Molecular Weight    36,949 Da
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 NCBI Official Full Name    Homo sapiens BMI1 polycomb ring finger oncogene (BMI1), mRNA
 NCBI Official Synonym Full Names    BMI1 proto-oncogene, polycomb ring finger
 NCBI Official Symbol    BMI1 [Similar Products]
 NCBI Official Synonym Symbols   
PCGF4; RNF51; FLVI2/BMI1
[Similar Products]
 NCBI Protein Information    polycomb complex protein BMI-1; flvi-2/bmi-1; ring finger protein 51; polycomb group protein Bmi1; BMI1 polycomb ring finger oncogene; polycomb group RING finger protein 4; BMI1 polycomb ring finger proto-oncogene; B lymphoma Mo-MLV insertion region 1 homolog; murine leukemia viral (bmi-1) oncogene homolog
 UniProt Protein Name    Polycomb complex protein BMI-1
 UniProt Synonym Protein Names   
Polycomb group RING finger protein 4; RING finger protein 51
 Protein Family    Polycomb complex protein
 UniProt Gene Name    BMI1 [Similar Products]
 UniProt Synonym Gene Names    PCGF4; RNF51 [Similar Products]
 UniProt Entry Name    BMI1_HUMAN
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 NCBI Summary for Bmi1    This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Bmi1    BMI1: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. Component of a PRC1-like complex. Interacts with RING1 and RING2. Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1.

Protein type: Ubiquitin conjugating system; Ubiquitin ligase; Ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; Oncoprotein

Chromosomal Location of Human Ortholog: 10p11.23

Cellular Component: nucleoplasm; heterochromatin; nuclear body; cytoplasm; PcG protein complex; nucleus; ubiquitin ligase complex

Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; ubiquitin-protein ligase activity; chromatin binding

Biological Process: transcription, DNA-dependent; in utero embryonic development; positive regulation of immature T cell proliferation in the thymus; negative regulation of transcription from RNA polymerase II promoter; humoral immune response; embryonic skeletal morphogenesis; segment specification; rostrocaudal neural tube patterning; positive regulation of fibroblast proliferation; regulation of gene expression; positive regulation of ubiquitin-protein ligase activity; histone ubiquitination; DNA methylation; positive regulation of B cell proliferation; somatic stem cell division; hemopoiesis; histone acetylation; brain development
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 Research Articles on Bmi1    1. Bmi-1 might be involved in gastric cancer at both transcription and translation levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Bmi1 antibodyPathways associated with anti-Bmi1 antibody
 Reference Product  PubMed Publications
 RING1 antibody  >37 publications with Bmi1 and RING1
 RNF2 antibody  >19 publications with Bmi1 and RNF2
 CBX4 antibody  >15 publications with Bmi1 and CBX4
 CBX2 antibody  >12 publications with Bmi1 and CBX2
 PHC1 antibody  >9 publications with Bmi1 and PHC1
 CBX7 antibody  >8 publications with Bmi1 and CBX7
 CBX8 antibody  >5 publications with Bmi1 and CBX8
 PHC2 antibody  >4 publications with Bmi1 and PHC2
 PHC3 antibody  >2 publications with Bmi1 and PHC3
 CBX6 antibody  >1 publications with Bmi1 and CBX6
 Products by Pathway  Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Oxidative Stress Induced Senescence Pathway antibodies  Oxidative Stress Induced Senescence Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Organs/Tissues associated with anti-Bmi1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >93 publications with Bmi1 and Brain
 Blood Antibodies  >89 publications with Bmi1 and Blood
 Bone Antibodies  >80 publications with Bmi1 and Bone
 Lung Antibodies  >54 publications with Bmi1 and Lung
 Bone Marrow Antibodies  >49 publications with Bmi1 and Bone Marrow
 Lymph Node Antibodies  >45 publications with Bmi1 and Lymph Node
 Liver Antibodies  >43 publications with Bmi1 and Liver
 Prostate Antibodies  >40 publications with Bmi1 and Prostate
 Intestine Antibodies  >39 publications with Bmi1 and Intestine
 Embryonic Tissue Antibodies  >39 publications with Bmi1 and Embryonic Tissue
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