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anti-BGLAP antibody :: Mouse Bovine Osteocalcin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190074 anti-BGLAP antibody
Unit / Price
0.1 mg  /  $450 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bovine Osteocalcin (BGLAP), Monoclonal Antibody

 Also Known As   

Bovine Osteocalcin Monoclonal Antibody

 Product Synonym Names    Bovine Osteocalcin; Osteocalcin
 Product Gene Name   

anti-BGLAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (156211951..156213112). Location: 1q25-q31
 OMIM    112260
 3D Structure    ModBase 3D Structure for P02818
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 Clonality    Monoclonal
 Clone Number    OC4-30
 Host    Mouse
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 Specificity    Bovine Osteocalcin [Mouse monoclonal antibody to Bovine Osteocalcin]
Epitope: Residues 4-9
Subclass: IgG1 : Reactivity: Bov, Hu, Rbt, Pig, Dog, Goat, Sheep, Chicken; none with Mouse or Rat
 Form/Format    100 ug IgG in 10 mM PBS, pH 7.4, lyophilized.
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 Antigen    Bovine osteocalcin
 Stabilizer    1% BSA
 Preservatives    0.1% Sodium Azide
 Dilutions Instructions    Reconstitute in distilled water to the final desired concentration.
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 Preparation and Storage    Lyophilized antibody is stable at 4 degree C for 2 years. Store the reconstituted solution in aliquots at -20 degree C for one year or at 4 degree C for 6 months. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-BGLAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-BGLAP antibody    Hormone and Serum Protein Antibodies
 Applications Tested/Suitable for anti-BGLAP antibody   

ELISA, Western Blot, Immunohistochemistry

 Application Notes for anti-BGLAP antibody    Immunohistochemistry: 10 ug/ml on paraffin embedded and frozen tissue sections.
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NCBI/Uniprot data below describe general gene information for BGLAP. It may not necessarily be applicable to this product.
 NCBI GI #    40316933
 NCBI GeneID    632
 NCBI Accession #    NP_954642.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199173.4 [Other Products]
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 UniProt Primary Accession #    P02818 [Other Products]
 UniProt Secondary Accession #    Q5TCK6 [Other Products]
 UniProt Related Accession #    P02818 [Other Products]
 Molecular Weight    10,963 Da [Similar Products]
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 NCBI Official Full Name    osteocalcin preproprotein
 NCBI Official Synonym Full Names    bone gamma-carboxyglutamate (gla) protein
 NCBI Official Symbol    BGLAP [Similar Products]
 NCBI Official Synonym Symbols   
OC; BGP
[Similar Products]
 NCBI Protein Information    osteocalcin; bone Gla protein; OTTHUMP00000016586; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin)
 UniProt Protein Name    Osteocalcin
 UniProt Synonym Protein Names   
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
 Protein Family    Osteocalcin
 UniProt Gene Name    BGLAP [Similar Products]
 UniProt Entry Name    OSTCN_HUMAN
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 NCBI Summary for BGLAP    This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
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 UniProt Comments for BGLAP    osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.

Protein type: Secreted; Secreted, signal peptide; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; cytoplasm; dendrite; perikaryon

Molecular Function: structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity

Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; osteoblast differentiation; odontogenesis; regulation of osteoclast differentiation; response to vitamin D; response to ethanol; response to vitamin K; response to estrogen stimulus; response to mechanical stimulus; response to zinc ion; response to hydroxyisoflavone; response to activity; cell adhesion; regulation of bone mineralization; skeletal development
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 Research Articles on BGLAP    1. Data show that osteocalcin synthesis was significantly reduced in the stable HSP27-transfected MC3T3-E1 cells and normal human osteoblasts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BGLAP antibodyDiseases associated with anti-BGLAP antibody
 Products by Pathway  Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic M-M/G1 Phases Pathway antibodies  Mitotic M-M/G1 Phases Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
 Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies  Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram
 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >4 publications with BGLAP and Bone Diseases
 Bone Resorption Antibodies  >4 publications with BGLAP and Bone Resorption
 Neoplasms Antibodies  >3 publications with BGLAP and Neoplasms
 Metabolic Diseases Antibodies  >3 publications with BGLAP and Metabolic Diseases
 Osteoporosis Antibodies  >3 publications with BGLAP and Osteoporosis
 Leukemia Antibodies  >2 publications with BGLAP and Leukemia
 Diabetes Mellitus Antibodies  >2 publications with BGLAP and Diabetes Mellitus
 Insulin Resistance Antibodies  >2 publications with BGLAP and Insulin Resistance
 Hypertension Antibodies  >1 publications with BGLAP and Hypertension
 Adenocarcinoma Antibodies  >1 publications with BGLAP and Adenocarcinoma
Organs/Tissues associated with anti-BGLAP antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >23 publications with BGLAP and Bone
 Brain Antibodies  >2 publications with BGLAP and Brain
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