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anti-Bcan antibody :: Mouse anti-Rat, Mouse Brevican Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS801724
Western Blot (WB)
Unit / Price
0.1 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Brevican (Bcan), Monoclonal Antibody

 Also Known As   

Brevican Antibody: FITC

 Product Synonym Names    BCAN; BEHAB; CSPG7; Brain enriched hyaluronan binding protein antibody; Brevican core protein; Brevican core protein isoform 1; Brevican core protein isoform 2; Brevican proteoglycan; Chondroitin sulfate proteoglycan 7
 Product Gene Name   

anti-Bcan antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Brevican Clone #S294A-6 (MBS800457)
FITC Conjugated Antibody: Brevican Clone #S294A-6 (MBS801724)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P55068
 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    S294A-6
 Host    Mouse
 Species Reactivity    Rat, Mouse
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 Form/Format    Protein G Purified
 Concentration    1mg/mL (lot specific)
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 Conjugate    FITC
 Storage Buffer    PBS pH7.4, 50% glycerol, 0.09% sodium azide
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 Preparation and Storage    -20 degree C
 Other Notes    Small volumes of anti-Bcan antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Bcan antibody

   Background Info: Detects ~140kDa (and smaller due to proteolytic cleavage)

Scientific Background: Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.
 Product Categories/Family for anti-Bcan antibody    Neuroscience
 Applications Tested/Suitable for anti-Bcan antibody   

Immunocytochemistry (ICC), Western Blot (WB)

 Application Notes for anti-Bcan antibody    1:1000 (WB)
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 Western Blot (WB) of anti-Bcan antibody    Western Blot analysis of Rat Brain Membrane showing detection of ~140 kDa Brevican protein using Mouse Anti-Brevican Monoclonal Antibody, Clone S294A-6. Lane 1: MW Ladder. Lane 2: Rat Brain Membrane (10 ug). Load: 10 ug. Block: 5% milk. Primary Antibody: Mouse Anti-Brevican Monoclonal Antibody at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: TMB solution for 10 min at RT. Predicted/Observed Size: ~140 kDa.
anti-Bcan antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Bcan. It may not necessarily be applicable to this product.
 NCBI GI #    75992948
 NCBI GeneID    25393
 NCBI Accession #    NP_001028837.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033665.1 [Other Products]
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 UniProt Primary Accession #    P55068 [Other Products]
 UniProt Secondary Accession #    Q62860; Q63040; Q63513 [Other Products]
 UniProt Related Accession #    P55068 [Other Products]
 Molecular Weight    69,085 Da [Similar Products]
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 NCBI Official Full Name    brevican core protein isoform 1
 NCBI Official Synonym Full Names    brevican
 NCBI Official Symbol    Bcan [Similar Products]
 NCBI Official Synonym Symbols   
BEHAB; ALPBRE
[Similar Products]
 NCBI Protein Information    brevican core protein; brain-enriched hyaluronan-binding protein; brevican (brain specific proteoglycan in the aggrecan family)
 UniProt Protein Name    Brevican core protein
 UniProt Synonym Protein Names   
Brain-enriched hyaluronan-binding protein; BEHAB
 Protein Family    Brevican core protein
 UniProt Gene Name    Bcan [Similar Products]
 UniProt Synonym Gene Names    Behab; BEHAB [Similar Products]
 UniProt Entry Name    PGCB_RAT
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 NCBI Summary for Bcan    brain-specific member of the aggrecan family of chondroitin sulfate proteoglycans; extracellular matrix (ECM) protein; binds hyaluronan, a ubiquitous component of the ECM [RGD, Feb 2006]
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 UniProt Comments for Bcan    BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; proteinaceous extracellular matrix; dendrite; synapse

Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding

Biological Process: central nervous system development; hippocampus development; cell adhesion; skeletal development; regulation of neuronal synaptic plasticity
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Product References and Citations for anti-Bcan antibody

   1. Yamada H., Watanabe K., Shimonaka M. and Yamaguchi Y. (1994) J. Biol. Chem. 269: 10119-10126. 2. Yamada H., Watanabe K., Shimonaka M., Yamasaki M. and Yamaguchi Y. (1995) Biochem. Biophys. Res. Commun. 216: 957-963. 3. Rauch U., et al. (1997) Genomics 44: 15-21. 4. Zhang H., Kelly G., Zerillo C., Jaworski D.M. and Hockfield S. (1998) J. Neurosci. 7: 2370-2376. 5. Aspberg A., Adam S., Kostka G., Timpl R. and Heinegard D. (1999) J. Biol. Chem. 274: 20444-20449.
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 Research Articles on Bcan    1. Brevican deposition is elevated in response to progressive gray matter injury, whereas diminished versican expression may be associated with deep cerebral white matter injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Bcan antibodyDiseases associated with anti-Bcan antibody
 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >51 publications with Bcan and Nervous System Diseases
 Disease Models, Animal Antibodies  >16 publications with Bcan and Disease Models, Animal
 Spinal Cord Diseases Antibodies  >14 publications with Bcan and Spinal Cord Diseases
 Urinary Bladder Neoplasms Antibodies  >8 publications with Bcan and Urinary Bladder Neoplasms
 Inflammation Antibodies  >7 publications with Bcan and Inflammation
 Lung Neoplasms Antibodies  >3 publications with Bcan and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with Bcan and Neoplasms, Experimental
 Lung Diseases Antibodies  >3 publications with Bcan and Lung Diseases
 Breast Neoplasms Antibodies  >3 publications with Bcan and Breast Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with Bcan and Congenital Abnormalities
Organs/Tissues associated with anti-Bcan antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >121 publications with Bcan and Brain
 Dorsal Root Ganglion Antibodies  >5 publications with Bcan and Dorsal Root Ganglion
 Pituitary Gland Antibodies  >2 publications with Bcan and Pituitary Gland
 Eye Antibodies  >1 publications with Bcan and Eye
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