NP_001028837.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
brevican core protein isoform 1
NCBI Official Synonym Full Names
brevican
NCBI Protein Information
brevican core protein; brain-enriched hyaluronan-binding protein; brevican (brain specific proteoglycan in the aggrecan family)
UniProt Protein Name
Brevican core protein
UniProt Synonym Protein Names
Brain-enriched hyaluronan-binding protein; BEHAB
UniProt Synonym Gene Names
UniProt Entry Name
PGCB_RAT
NCBI Summary for Bcan
brain-specific member of the aggrecan family of chondroitin sulfate proteoglycans; extracellular matrix (ECM) protein; binds hyaluronan, a ubiquitous component of the ECM [RGD, Feb 2006]
UniProt Comments for Bcan
BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Secreted; Secreted, signal peptide
Cellular Component: extracellular space; proteinaceous extracellular matrix; dendrite; synapse
Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding
Biological Process: central nervous system development; hippocampus development; cell adhesion; skeletal development; regulation of neuronal synaptic plasticity
Product References and Citations for anti-Bcan antibody
1. Yamada H., Watanabe K., Shimonaka M. and Yamaguchi Y. (1994) J. Biol. Chem. 269: 10119-10126. 2. Yamada H., Watanabe K., Shimonaka M., Yamasaki M. and Yamaguchi Y. (1995) Biochem. Biophys. Res. Commun. 216: 957-963. 3. Rauch U., et al. (1997) Genomics 44: 15-21. 4. Zhang H., Kelly G., Zerillo C., Jaworski D.M. and Hockfield S. (1998) J. Neurosci. 7: 2370-2376. 5. Aspberg A., Adam S., Kostka G., Timpl R. and Heinegard D. (1999) J. Biol. Chem. 274: 20444-20449.
Research Articles on Bcan
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Pathways associated with anti-Bcan antibody
Diseases associated with anti-Bcan antibody
Organs/Tissues associated with anti-Bcan antibody
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