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anti-Pou4f1 antibody :: Mouse Brn3A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601428 anti-Pou4f1 antibody
Unit / Price
1 mL  /  $680 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Brn3A (Pou4f1), Monoclonal Antibody

 Also Known As   

Brn3A (Pou Domain Transcription Factor)

 Product Synonym Names    Anti -Brn3A (Pou Domain Transcription Factor)
 Product Gene Name   

anti-Pou4f1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    chromosome: 14; Location: 14; 14 E1-E3
 3D Structure    ModBase 3D Structure for P17208
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2Q24
 Host    Mouse
 Species Reactivity    Chicken, Monkey
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 Specificity    Brn-3a. Shows no reactivity to Brn-3b or Brn-3c by Western blot. Showed no reactivity to Brn-3a knock-out mice. Species Reactivity: Monkey and chicken
 Purity/Purification    Supernatant
Culture supernatant
 Form/Format    Supplied as a liquid. No preservative added.
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 Immunogen    aa186-224 of Brn-3a fused to the T7 gene 10 protein (1).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Pou4f1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Pou4f1 antibody

   Brn3a (transcription factor 1 (brain specific homeobox/POU domain protein 3A) POU4F1, POU domain, class 4, RDC-1) is a transcription factor specifically expressed in cells of the developing mammalian nervous system.
 Product Categories/Family for anti-Pou4f1 antibody    Antibodies; Abs to Proteins
 Applications Tested/Suitable for anti-Pou4f1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Pou4f1 antibody    Suitable for use in Immunohistochemistry, Western Blot.
Dilution: Immunohistochemistry: 1:5-1:125
Western blot: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for Pou4f1. It may not necessarily be applicable to this product.
 NCBI GI #    51921650
 NCBI GeneID    18996
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 UniProt Primary Accession #    P17208 [Other Products]
 UniProt Secondary Accession #    E9QPT6 [Other Products]
 UniProt Related Accession #    P17208; Q64FM2; Q78NA5; Q80ZA2 [Other Products]
 Molecular Weight    42,767 Da [Similar Products]
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 NCBI Official Full Name    Brn3a
 NCBI Official Synonym Full Names    POU domain, class 4, transcription factor 1
 NCBI Official Symbol    Pou4f1 [Similar Products]
 NCBI Official Synonym Symbols   
Brn3; Brn-3; Brn3a; Brn3.0; Brn-3.0; E130119J07Rik; Pou4f1
[Similar Products]
 NCBI Protein Information    POU domain, class 4, transcription factor 1; brn-3A; brain-3A; brain-specific homeobox/POU domain protein 3A
 UniProt Protein Name    POU domain, class 4, transcription factor 1
 UniProt Synonym Protein Names   
Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A; Brn-3.0
 Protein Family    POU domain, class 4, transcription factor
 UniProt Gene Name    Pou4f1 [Similar Products]
 UniProt Synonym Gene Names    Brn-3; Brn3; Brn3a [Similar Products]
 UniProt Entry Name    PO4F1_MOUSE
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 UniProt Comments for Pou4f1    POU4F1: Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons. Belongs to the POU transcription factor family. Class- 4 subfamily.

Protein type: DNA-binding; Cell development/differentiation; Transcription factor

Cellular Component: neuron projection; nuclear chromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; nervous system development; trigeminal nerve development; central nervous system neuron differentiation; transcription, DNA-dependent; positive regulation of apoptosis; multicellular organismal development; peripheral nervous system neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; habenula development; regulation of transcription from RNA polymerase II promoter; cell migration in hindbrain; neuron differentiation; peripheral nervous system neuron development; proprioception during equilibrioception; regulation of neurogenesis; regulation of transcription, DNA-dependent; suckling behavior; neuron fate specification; mesoderm development; positive regulation of transcription from RNA polymerase II promoter; sensory system development; negative regulation of neuron apoptosis
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 Research Articles on Pou4f1    1. data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins
2. Data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes.
3. Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.
4. these findings begin to define a gene regulatory pathway for habenula development in mammals, and the roles of Nurr1 and Brn3a therein.
5. Brn-3a deficiency affects the number and cell size of CGRP- and calcium-binding protein-containing neurons.
6. Loss of Brn3a leads to an increase in the ratio of bistratified to monostratified RGCs, with only modest RGC loss and little effect on central projections.
7. Brn3a represses differences in gene expression between sensory neurons generated at different axial levels, and regulates developmental gene expression; functionally similar populations of neurons are generated from different embryological substrates.
8. results suggest that co-factors binding to p73 C terminus facilitate activation on Bax but not p21 CIP1/Waf1 promoter and that Brn-3a modulates this interaction
9. Data suggest that Brn-3a and b POU factors may play an important role in the development and maintenance of critical cell types and structures within the heart, in part via developmental regulation of myocardial Hsp27 expression.
10. Data show that Pou4f1 is regionally enriched in the Brainstem (Pons and Medulla) of mouse brain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-Pou4f1 antibodyOrgans/Tissues associated with anti-Pou4f1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >25 publications with Pou4f1 and Neoplasms
 Nervous System Diseases Antibodies  >16 publications with Pou4f1 and Nervous System Diseases
 Uterine Cervical Neoplasms Antibodies  >7 publications with Pou4f1 and Uterine Cervical Neoplasms
 Brain Diseases Antibodies  >4 publications with Pou4f1 and Brain Diseases
 Pain Antibodies  >4 publications with Pou4f1 and Pain
 Cervical Intraepithelial Neoplasia Antibodies  >4 publications with Pou4f1 and Cervical Intraepithelial Neoplasia
 Leukemia, Myeloid, Acute Antibodies  >3 publications with Pou4f1 and Leukemia, Myeloid, Acute
 Disease Models, Animal Antibodies  >3 publications with Pou4f1 and Disease Models, Animal
 Nerve Degeneration Antibodies  >1 publications with Pou4f1 and Nerve Degeneration
 Craniofacial Abnormalities Antibodies  >1 publications with Pou4f1 and Craniofacial Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with Pou4f1 and Brain
 Eye Antibodies  >21 publications with Pou4f1 and Eye
 Dorsal Root Ganglion Antibodies  >17 publications with Pou4f1 and Dorsal Root Ganglion
 Embryonic Tissue Antibodies  >15 publications with Pou4f1 and Embryonic Tissue
 Spinal Cord Antibodies  >8 publications with Pou4f1 and Spinal Cord
 Liver Antibodies  >4 publications with Pou4f1 and Liver
 Testis Antibodies  >1 publications with Pou4f1 and Testis
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