NP_001189668.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
BUB1-related protein BUBR1
NCBI Official Synonym Symbols
BUB1-related (BUB1: budding uninhibited by benzymidazol 1); BUBR1; F4P9.33; F4P9_33 [Similar Products]
NCBI Protein Information
BUB1-related protein BUBR1
UniProt Protein Name
Mitotic spindle checkpoint protein BUBR1
UniProt Synonym Protein Names
BUB1-related protein 1
UniProt Synonym Gene Names
UniProt Entry Name
BUBR1_ARATH
NCBI Summary for BUBR1
Encodes BUBR1. May have the spindle assembly checkpoint protein functions conserved from yeast to humans.
UniProt Comments for BUBR1
Function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions may be to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C
By similarity. Ref.5
Subunit structure: Interacts with anaphase-promoting complex/cyclosome (APC/C)
By similarity. Part of the mitotic checkpoint complex (MCC); interacts with CDC20-1 and CDC20-2. Interacts with MAD2 at chromocenters and with BUB3.1. Ref.5 Ref.6
Subcellular location: Chromosome. Cytoplasm. Nucleus. Chromosome › centromere › kinetochore. Cytoplasm › cytoskeleton › spindle. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome
By similarity. Note: Cytoplasmic in interphase cells. Accumulates onto both kinetochores and the spindle microtubules in cell arrested in metaphase. Associates with unattached kinetochores in early prophase upon spindle assembly checkpoint (SAC) activation. Present in chromocenters. Ref.5
Tissue specificity: Expressed in actively dividing tissues, early in organ development, in young leaves, lateral root primordia and root meristems. Ref.5
Induction: Cell cycle regulated expression with a distinct expression peak at the G2/M boundary. Ref.5
Domain: The KEN box is required for its ubiquitination and degradation
By similarity.BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.
Sequence similarities: Contains 1 BUB1 N-terminal domain.
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Products associated with anti-BUBR1 antibody
Organs/Tissues associated with anti-BUBR1 antibody
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