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anti-C-MYC antibody :: Mouse C-MYC Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS215610
Unit / Price
0.1 mg  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-MYC, Monoclonal Antibody

★Popular Item★
 Also Known As   

MOUSE ANTI C-MYC:ALK.PHOS.

 Product Gene Name   

anti-C-MYC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113970
 3D Structure    ModBase 3D Structure for P01106
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9E10
 Host    Mouse
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 Form/Format    Alk. Phos.
Purified IgG conjugated to Alkaline Phosphatase - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-C-MYC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-C-MYC antibody

   Mouse anti c-myc antibody, clone 9E10 detects the p62c-myc proto-oncogene protein, which is involved in the regulation of the cell cycle and cell growth. C-myc is primarily located to the cell nucleus, but has also been shown to localised to the cytoplasm in several cell lines (Craig et al. 1993). Overexpression of c-myc has been reported in a wide variety of human cancers (Nesbit et al. 1999). Mouse anti c-myc antibody, clone 9E10 recognizes the sequence EQKLISEEDL and may be used to detect proteins and peptides labelled with molecular tags containing this sequence (Hilpert et al. 2001).
 Applications Tested/Suitable for anti-C-MYC antibody   

Immunohistology Frozen, ELISA (EIA), Immunohistology Paraffin, Western Blot (WB)*

 Application Notes for anti-C-MYC antibody    Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections prior to staining This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
ELISA: Minimum Dilution: 1/500; Maximum Dilution: 1/5000
Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/500; Application Note: 9E10 recognizes c-myc under non-reducing conditions
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 Testing Data of anti-C-MYC antibody    c-myc tagged protein detected with Mouse anti c-myc:Alk Phos
anti-C-MYC antibody Testing Data image
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 Testing Data of anti-C-MYC antibody    Western blot analysis of HEK293 embryonic kidney cell line whole cell lysate probed with Mouse anti Human c-myc antibody (MBS212564) followed by HRP conjugated Goat anti Mouse IgG secondary antibody visualized using chemiluminescence
anti-C-MYC antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for C-MYC. It may not necessarily be applicable to this product.
 NCBI GI #    71774083
 NCBI GeneID    4609
 NCBI Accession #    NP_002458.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002467.4 [Other Products]
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 UniProt Primary Accession #    P01106 [Other Products]
 UniProt Secondary Accession #    P01107; Q14026; A8WFE7 [Other Products]
 UniProt Related Accession #    P01106 [Other Products]
 Molecular Weight    50,565 Da
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 NCBI Official Full Name    myc proto-oncogene protein
 NCBI Official Synonym Full Names    v-myc avian myelocytomatosis viral oncogene homolog
 NCBI Official Symbol    MYC [Similar Products]
 NCBI Official Synonym Symbols   
MRTL; MYCC; c-Myc; bHLHe39
[Similar Products]
 NCBI Protein Information    myc proto-oncogene protein; avian myelocytomatosis viral oncogene homolog; class E basic helix-loop-helix protein 39; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc myelocytomatosis viral oncogene homolog
 UniProt Protein Name    Myc proto-oncogene protein
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
 Protein Family    C-Myc-binding protein
 UniProt Gene Name    MYC [Similar Products]
 UniProt Synonym Gene Names    BHLHE39; bHLHe39 [Similar Products]
 UniProt Entry Name    MYC_HUMAN
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 NCBI Summary for C-MYC    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C-MYC    Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: Nucleolus; Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: nucleoplasm; protein complex; nucleolus; cytosol; nucleus

Molecular Function: protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity

Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; regulation of telomere maintenance; transcription, DNA-dependent; MAPKKK cascade; negative regulation of cell division; negative regulation of stress-activated MAPK cascade; negative regulation of monocyte differentiation; chromatin remodeling; regulation of gene expression; ureteric bud branching; negative regulation of fibroblast proliferation; energy reserve metabolic process; positive regulation of transcription from RNA polymerase II promoter; gene expression; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis

Disease: Burkitt Lymphoma
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 Research Articles on C-MYC    1. A conserved Myc region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 is recruited to Myc-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C-MYC antibodyPathways associated with anti-C-MYC antibody
 Reference Product  PubMed Publications
 MAX antibody  >993 publications with C-MYC and MAX
 SP1 antibody  >295 publications with C-MYC and SP1
 FBXW7 antibody  >100 publications with C-MYC and FBXW7
 SKP2 antibody  >85 publications with C-MYC and SKP2
 TRRAP antibody  >42 publications with C-MYC and TRRAP
 EP300 antibody  >19 publications with C-MYC and EP300
 PFDN5 antibody  >12 publications with C-MYC and PFDN5
 UBC antibody  >11 publications with C-MYC and UBC
 GSK3B antibody  >6 publications with C-MYC and GSK3B
 PIAS2 antibody  >3 publications with C-MYC and PIAS2
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
Diseases associated with anti-C-MYC antibodyOrgans/Tissues associated with anti-C-MYC antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3851 publications with C-MYC and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >2619 publications with C-MYC and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >2254 publications with C-MYC and Neoplasms, Experimental
 Neuroectodermal Tumors Antibodies  >2215 publications with C-MYC and Neuroectodermal Tumors
 Adenocarcinoma Antibodies  >1678 publications with C-MYC and Adenocarcinoma
 Neuroblastoma Antibodies  >1515 publications with C-MYC and Neuroblastoma
 Disease Models, Animal Antibodies  >1473 publications with C-MYC and Disease Models, Animal
 Breast Neoplasms Antibodies  >1430 publications with C-MYC and Breast Neoplasms
 Liver Neoplasms Antibodies  >1088 publications with C-MYC and Liver Neoplasms
 Disease Progression Antibodies  >1069 publications with C-MYC and Disease Progression
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3597 publications with C-MYC and Blood
 Liver Antibodies  >1967 publications with C-MYC and Liver
 Lung Antibodies  >1444 publications with C-MYC and Lung
 Bone Antibodies  >1366 publications with C-MYC and Bone
 Brain Antibodies  >1210 publications with C-MYC and Brain
 Muscle Antibodies  >1144 publications with C-MYC and Muscle
 Bone Marrow Antibodies  >954 publications with C-MYC and Bone Marrow
 Vascular Antibodies  >919 publications with C-MYC and Vascular
 Kidney Antibodies  >845 publications with C-MYC and Kidney
 Prostate Antibodies  >747 publications with C-MYC and Prostate
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