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anti-raf1a antibody :: Mouse C-Raf (N-terminal Region) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS470008
Testing Data
Unit / Price
0.1 mL  /  $280 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-Raf (N-terminal Region) (raf1a), Monoclonal Antibody

★Popular Item★
 Also Known As   

C-Raf (N-terminal Region)

 Product Synonym Names    Raf-1
 Product Gene Name   

anti-raf1a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 23; NC_007134.5 (4764341..4775456)
 3D Structure    ModBase 3D Structure for Q90458
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 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
 Species Reactivity    Human, Rat, Mouse
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 Specificity    This antibody detects a 74 kDa* protein corresponding to the molecular mass of C-Raf on SDS-PAGE immunoblots of human A431 and Jurkat cells.
 Purity/Purification    Protein G Purified
 Form/Format    Mouse monoclonal, protein G purified antibody is supplied in 100ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
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 Immunogen    Clone (M208) was generated from a sequence corresponding to amino acids in the N-terminal region of human C-Raf. This C-Raf sequence has high homology to rat and mouse C-Raf.
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 Preparation and Storage    Store at -20 degree C. Do not aliquot. Stable for 1 year.
 Other Notes    Small volumes of anti-raf1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-raf1a antibody

   The Ras-Raf-MAP kinase signaling pathway is involved in control of cell proliferation and differentiation. The Raf kinase family includes A-Raf, BRaf, and C-Raf. Each family member has three highly conserved regions (CR1-3). The N-terminal CR1 contains the Ras-GTP-binding domain. The CR2 contains a negative regulatory serine residue (C-Raf (S259)/B-Raf (S365)) that may bind 14-3-3 proteins. The CR3 is the catalytic domain that contains phosphorylation sites for Raf-regulating enzymes within two segments, the N-region and the activation segment. Activation of C-Raf involves phosphorylation at many sites including Ser-338, Tyr-341, and multiple catalytic domain sites. EGF receptor activation leads to phosphorylation of Ser-471, which is critical for C-Raf kinase activity and is required for interaction with MEK. In B-Raf, the corresponding conserved site is Ser-578, and mutation of this residue to alanine produces an inactivate kinase. Thus, this Raf phosphorylation site may be critical for kinase activity and may be important for MEK binding and activation.
 Applications Tested/Suitable for anti-raf1a antibody   

ELISA, Western Blot

 Application Notes for anti-raf1a antibody    ELISA: 1:2000
Western Blot: 1:1000
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 Testing Data of anti-raf1a antibody    anti-raf1a antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for raf1a. It may not necessarily be applicable to this product.
 NCBI GI #    534977
 NCBI GeneID    30716
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 UniProt Primary Accession #    Q90458 [Other Products]
 UniProt Related Accession #    Q6BE22; Q76FQ3; Q76I87; Q7ZTR8; Q7ZZW3; Q90458 [Other Products]
 Molecular Weight    34,871 Da [Similar Products]
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 NCBI Official Full Name    c-raf
 NCBI Official Synonym Full Names    v-raf-1 murine leukemia viral oncogene homolog 1a
 NCBI Official Symbol    raf1a [Similar Products]
 NCBI Official Synonym Symbols   
craf; raf1; c-raf
[Similar Products]
 NCBI Protein Information    RAF proto-oncogene serine/threonine-protein kinase; serine/threonine protein kinase RAF1; murine leukemia viral oncogene homolog; v-raf-1 murine leukemia viral oncogene homolog 1
 UniProt Protein Name    C-raf protein
 UniProt Gene Name    raf1a [Similar Products]
 UniProt Synonym Gene Names    c-raf [Similar Products]
 UniProt Entry Name    Q90458_DANRE
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Product References and Citations for anti-raf1a antibody

   • Mason, C.S. et al. (1999) EMBOJ 18(8):2137.
• Zhu, J. et al. (2005). Mol. Biol. Cell 16:4733.
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 Research Articles on raf1a    1. analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-raf1a antibody
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 ERK1 - ERK2 MAPK Cascade Pathway antibodies  ERK1 - ERK2 MAPK Cascade Pathway Diagram
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