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| Product Name
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C Reactive Protein (CRP), Monoclonal Antibody
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| Also Known As
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MAb to CRP
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| Product Synonym Names
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Monoclonal Antibody to Human C Reactive Protein (CRP)
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Chromosome Location
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Chromosome: 1; NC_000001.10 (159682079..159684379, complement). Location: 1q21-q23
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| OMIM
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123260
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| 3D Structure
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ModBase 3D Structure for P02741
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| Clonality
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Monoclonal
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| Isotype
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IgG1
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| Clone Number
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C2
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| Host
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Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.
Source: Ascites
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| Species Reactivity
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Human
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| Specificity
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C Reactive Protein (CRP)
Human CRP. Recognizes antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
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| Purity/Purification
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>90% pure (SDS-PAGE). Protein A chromatography
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| Form/Format
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Biotin, Liquid
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| Concentration
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1.2mg/ml (Sigma protein assay kit) (lot specific)
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| Immunogen
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Purified Human CRP
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| Affinity Constant
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Not determined
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| Buffer
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20mM Tris-HCl, pH 7.5 containing 150mM Sodium chloride
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| Preservative
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0.1% Sodium azide
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| Important Note
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Centrifuge before opening to ensure complete recovery of vial contents.
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| Warnings
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This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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| Preparation and Storage
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Store at 2 to 8 degree C.
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of anti-CRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Product Categories/Family for anti-CRP antibody
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Monoclonal Antibodies to Proteins and Bioactive Peptides
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| NCBI/Uniprot data below describe general gene information for CRP. It may not necessarily be applicable to this product. |
| NCBI GI #
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117486
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| NCBI GeneID
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1401
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| NCBI Accession #
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P02741.1
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[Other Products]
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| UniProt Primary Accession #
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P02741
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[Other Products]
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| UniProt Secondary Accession #
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Q08AK3; Q8WW75; A8K078; D3DVD9; D3DVE0
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[Other Products]
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| UniProt Related Accession #
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P02741; Q5VVP7
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[Other Products]
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| Molecular Weight
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25,039 Da
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[Similar Products]
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TOP
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| NCBI Official Full Name
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C-reactive protein
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| NCBI Official Synonym Full Names
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C-reactive protein, pentraxin-related
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| NCBI Official Symbol
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CRP
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[Similar Products]
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| NCBI Official Synonym Symbols
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PTX1; MGC88244; MGC149895
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[Similar Products]
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| NCBI Protein Information
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C-reactive protein; pentraxin 1; OTTHUMP00000033307
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| UniProt Protein Name
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C-reactive protein
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| Protein Family
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Cryparin
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| UniProt Gene Name
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CRP
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[Similar Products]
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| UniProt Synonym Gene Names
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PTX1
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[Similar Products]
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| UniProt Entry Name
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CRP_HUMAN
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| NCBI Summary for CRP
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The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq]
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| UniProt Comments for CRP
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Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Cofactor: Binds 2 calcium ions per subunit.
Subunit structure: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
Subcellular location: Secreted.
Tissue specificity: Found in plasma.
Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6.
Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.
Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain.
Mass spectrometry: Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref.15Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref.15
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TOP
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| Research Articles on CRP
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1. Findings indicate that IL-6 is a powerful independent predictor of future CV events in high-risk Japanese patients, suggesting its predictive value is superior to hs-CRP.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with anti-CRP antibody | Pathways associated with anti-CRP antibody |
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| Diseases associated with anti-CRP antibody | Organs/Tissues associated with anti-CRP antibody |
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TOP
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Antibody 
