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anti-C1q antibody :: Mouse C1q Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214405 anti-C1q antibody
Unit / Price
0.1 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C1q, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN C1q

 Product Gene Name   

anti-C1q antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120550
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3R9/2
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    Approximate Protein Concentration: 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Histology Positive Control Tissue    Kidney from patients with streptococcal glomerulonephritis.
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from the date of despatch.
 Other Notes    Small volumes of anti-C1q antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-C1q antibody

   Mouse anti human C1q antibody, clone 3R9/2, recognizes human complement component 1 q (C1q), a 156kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A-, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis (Troedson et al. 2013).
 Applications Tested/Suitable for anti-C1q antibody   

Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-C1q antibody    Immunohistology: For best results MyBioSource recommend HISTAR detection kits.
Immunohistology - Frozen: Minimum Dilution: 1:500; Maximum Dilution: 1:1000
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NCBI/Uniprot data below describe general gene information for C1q. It may not necessarily be applicable to this product.
 NCBI GI #    7705753
 NCBI GeneID    712
 NCBI Accession #    NP_057075.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_015991.2 [Other Products]
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 UniProt Secondary Accession #    Q5T963; B2R4X2 [Other Products]
 UniProt Related Accession #    P02745 [Other Products]
 Molecular Weight    26,017 Da
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 NCBI Official Full Name    complement C1q subcomponent subunit A
 NCBI Official Synonym Full Names    complement component 1, q subcomponent, A chain
 NCBI Official Symbol    C1QA [Similar Products]
 NCBI Protein Information    complement C1q subcomponent subunit A; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain
 UniProt Protein Name    Complement C1q subcomponent subunit A
 Protein Family    C1q-related factor
 UniProt Gene Name    C1QA [Similar Products]
 UniProt Entry Name    C1QA_HUMAN
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 NCBI Summary for C1q    This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C1q    C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein binding

Biological Process: cell-cell signaling; innate immune response; complement activation, classical pathway; complement activation

Disease: C1q Deficiency
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 Research Articles on C1q    1. C1q expression correlates with active disease in human tuberculosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C1q antibodyPathways associated with anti-C1q antibody
 Reference Product  PubMed Publications
 C1QB antibody  >24 publications with C1q and C1QB
 C1QC antibody  >20 publications with C1q and C1QC
 C1S antibody  >3 publications with C1q and C1S
 C1R antibody  >3 publications with C1q and C1R
 TYROBP antibody  >2 publications with C1q and TYROBP
 CSF1R antibody  >1 publications with C1q and CSF1R
 SERPING1 antibody  >1 publications with C1q and SERPING1
 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-C1q antibodyOrgans/Tissues associated with anti-C1q antibody
 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >21 publications with C1q and Lupus Erythematosus, Systemic
 Inflammation Antibodies  >11 publications with C1q and Inflammation
 Nervous System Diseases Antibodies  >8 publications with C1q and Nervous System Diseases
 Necrosis Antibodies  >6 publications with C1q and Necrosis
 Liver Diseases Antibodies  >6 publications with C1q and Liver Diseases
 Brain Diseases Antibodies  >6 publications with C1q and Brain Diseases
 Kidney Diseases Antibodies  >5 publications with C1q and Kidney Diseases
 Breast Neoplasms Antibodies  >4 publications with C1q and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with C1q and Cardiovascular Diseases
 Hypertension Antibodies  >2 publications with C1q and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with C1q and Liver
 Spleen Antibodies  >9 publications with C1q and Spleen
 Kidney Antibodies  >8 publications with C1q and Kidney
 Vascular Antibodies  >7 publications with C1q and Vascular
 Brain Antibodies  >7 publications with C1q and Brain
 Bone Antibodies  >7 publications with C1q and Bone
 Muscle Antibodies  >6 publications with C1q and Muscle
 Skin Antibodies  >5 publications with C1q and Skin
 Lung Antibodies  >5 publications with C1q and Lung
 Eye Antibodies  >4 publications with C1q and Eye
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