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anti-C4d antibody :: Mouse C4d Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS212940 anti-C4d antibody
Unit / Price
0.1 mg  /  $635 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C4d, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN C4d (NEOANTIGEN)

 Product Gene Name   

anti-C4d antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120820
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    057-51.5.1.6
 Host    Mouse
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 Specificity    This item recognises a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation.

C4 has been linked to susceptibility to systemic lupus erythematosous.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.1% Sodium Azide (NaN3)
Preparation
 Immunogen    Purified human C4d
Histology Positive Control Tissue
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-C4d antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-C4d antibody

   MBS212940 recognises a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous.
 Applications Tested/Suitable for anti-C4d antibody   

Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS)

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NCBI/Uniprot data below describe general gene information for C4d. It may not necessarily be applicable to this product.
 NCBI GI #    178557739
 NCBI GeneID    721
 NCBI Accession #    NP_001002029.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002029.3 [Other Products]
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 UniProt Secondary Accession #    P01028; P78445; Q13160; Q13906; Q14033; Q14835; Q6U2E9; Q6U2G1; Q6U2I5; Q6U2L1; A2BHY4 [Other Products]
 UniProt Related Accession #    P0C0L5 [Other Products]
 Molecular Weight    192,751 Da
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 NCBI Official Full Name    complement C4-B preproprotein
 NCBI Official Synonym Full Names    complement component 4B (Chido blood group)
 NCBI Official Symbol    C4B [Similar Products]
 NCBI Official Synonym Symbols   
CH; C4F; CO4; C4B1; C4B2; C4B3; C4B5; C4BD; C4B12; C4B_2; CPAMD3
[Similar Products]
 NCBI Protein Information    complement C4-B; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; Chido form of C4; basic complement C4; complement C4B1a
 UniProt Protein Name    Complement C4-B
 UniProt Synonym Protein Names   
Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3Cleaved into the following 6 chains:Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain
 UniProt Gene Name    C4B [Similar Products]
 UniProt Synonym Gene Names    CO4; CPAMD3 [Similar Products]
 UniProt Entry Name    CO4B_HUMAN
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 NCBI Summary for C4d    This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C4d    C4B: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway. Defects in C4B are a cause of susceptibility to systemic lupus erythematosus (SLE). A chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Interindividual copy- number variation (CNV) of complement component C4 and associated polymorphisms result in different susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among subjects with only two copies of total C4. A high copy number is a protective factor against SLE. Defects in C4B are the cause of complement component 4B deficiency (C4BD). A rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus with or without associated glomerulonephritis.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: complement binding; endopeptidase inhibitor activity; carbohydrate binding

Biological Process: detection of molecule of bacterial origin; regulation of complement activation; innate immune response; opsonization; inflammatory response; complement activation, classical pathway; complement activation

Disease: Complement Component 4b Deficiency
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 Research Articles on C4d    1. Transplant glomerulopathy is associated with poor prognosis, independently of C4d detection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C4d antibodyPathways associated with anti-C4d antibody
 Reference Product  PubMed Publications
 C1S antibody  >65 publications with C4d and C1S
 TNXA antibody  >15 publications with C4d and TNXA
 CYP21A2 antibody  >12 publications with C4d and CYP21A2
 HLA-ABC antibody  >3 publications with C4d and HLA-ABC
 C5AR1 antibody  >1 publications with C4d and C5AR1
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
Organs/Tissues associated with anti-C4d antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1173 publications with C4d and Blood
 Kidney Antibodies  >392 publications with C4d and Kidney
 Liver Antibodies  >149 publications with C4d and Liver
 Heart Antibodies  >101 publications with C4d and Heart
 Lung Antibodies  >74 publications with C4d and Lung
 Brain Antibodies  >50 publications with C4d and Brain
 Muscle Antibodies  >49 publications with C4d and Muscle
 Bone Antibodies  >25 publications with C4d and Bone
 Spleen Antibodies  >24 publications with C4d and Spleen
 Nerve Antibodies  >18 publications with C4d and Nerve
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