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anti-C5AR1 antibody :: Mouse C5AR1 / CD88 / C5a Receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245494
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C5AR1 / CD88 / C5a Receptor, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal (IgG2a) to Human C5AR1 / CD88 / C5a Receptor

 Product Synonym Names    Anti-C5AR1 / CD88 / C5a Receptor Antibody IHC-plus; C5AR1; C5A; C5a-R; C5a ligand; C5a receptor; CD88; C5a anaphylatoxin receptor; C5AR; C5R1; CD88 antigen; Human C5AR1; CD88; C5a Receptor
 Product Gene Name   

anti-C5AR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113995
 3D Structure    ModBase 3D Structure for P21730
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
 Species Reactivity    Human, Rabbit
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 Specificity    Recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone 3H1738 was raised against a synthetic peptide Met1 -Asn31 and has recently been shown to recognize the heptameric peptide (D15DKDTLD21). Clone 3H1738 inhibits C5a binding to its receptor. Species cross-reactivity: Rabbit.
 Purity/Purification    Ion exchange Chromatography
 Form/Format    PBS, pH 7.4, 40% glycerol. No preservative added.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    C5aR - peptide: Met1 - Asn31.
 Immunogen Type    Synthetic peptide
 Immunogen    C5AR1 / CD88 / C5a Receptor antibody was raised against c5aR - peptide: Met1 - Asn31.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-C5AR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-C5AR1 antibody

   C5a Anaphylatoxin Receptor mediates the effects of one of the most potent chemotactic agents known, in a wide variety of inflammatory cell types. C5a receptor 1 has been implicated in asthma.
 Product Categories/Family for anti-C5AR1 antibody    Family: GPCR
Subfamily: Anaphylatoxin
 Applications Tested/Suitable for anti-C5AR1 antibody   

Immunohistochemistry (IHC - Paraffin), Flow Cytometry (FC/FACS), Functional Assay, Neutralization

 Application Notes for anti-C5AR1 antibody    Flo (1:50), Func, IHC-P (10 ug/ml), Neut
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-C5AR1 antibody    Anti-C5AR1 / CD88 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-C5AR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for C5AR1. It may not necessarily be applicable to this product.
 NCBI GI #    4502509
 NCBI GeneID    728
 NCBI Accession #    NP_001727.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001736.3 [Other Products]
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 UniProt Primary Accession #    P21730 [Other Products]
 UniProt Related Accession #    P21730 [Other Products]
 Molecular Weight    39,336 Da
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 NCBI Official Full Name    C5a anaphylatoxin chemotactic receptor 1
 NCBI Official Synonym Full Names    complement component 5a receptor 1
 NCBI Official Symbol    C5AR1 [Similar Products]
 NCBI Official Synonym Symbols   
C5A; C5AR; C5R1; CD88
[Similar Products]
 NCBI Protein Information    C5a anaphylatoxin chemotactic receptor 1; C5a-R; C5a ligand; C5a anaphylatoxin receptor; complement component 5 receptor 1
 UniProt Protein Name    C5a anaphylatoxin chemotactic receptor 1
 UniProt Synonym Protein Names   
C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88
 Protein Family    C5a anaphylatoxin chemotactic receptor
 UniProt Gene Name    C5AR1 [Similar Products]
 UniProt Synonym Gene Names    C5AR; C5R1; C5a-R; C5aR [Similar Products]
 UniProt Entry Name    C5AR1_HUMAN
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 UniProt Comments for C5AR1    C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: cell surface; integral to plasma membrane; basolateral plasma membrane; apical part of cell; cytoplasmic membrane-bound vesicle; plasma membrane

Molecular Function: complement component C5a receptor activity; complement component C5a binding; C5a anaphylatoxin receptor activity

Biological Process: neutrophil chemotaxis; sensory perception of chemical stimulus; organ regeneration; apoptosis; activation of MAPK activity; response to lipopolysaccharide; cell proliferation in hindbrain; signal transduction; chemotaxis; mRNA transcription from RNA polymerase II promoter; elevation of cytosolic calcium ion concentration; defense response to Gram-positive bacterium; phospholipase C activation; response to peptidoglycan; cellular defense response; immune response; negative regulation of neuron apoptosis; inflammatory response; positive regulation of epithelial cell proliferation
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 Research Articles on C5AR1    1. inhibition of TAFIa activity, however, was substrate-specific, because neither mAb inhibited the cleavage of thrombin-activated osteopontin and C5a by TAFIa, thus sparing the anti-inflammatory activity of TAFIa
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C5AR1 antibodyPathways associated with anti-C5AR1 antibody
 Reference Product  PubMed Publications
 C3AR1 antibody  >2 publications with C5AR1 and C3AR1
 GNAI2 antibody  >1 publications with C5AR1 and GNAI2
 FPR1 antibody  >1 publications with C5AR1 and FPR1
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Diseases associated with anti-C5AR1 antibodyOrgans/Tissues associated with anti-C5AR1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >41 publications with C5AR1 and Inflammation
 Immune System Diseases Antibodies  >21 publications with C5AR1 and Immune System Diseases
 Cardiovascular Diseases Antibodies  >11 publications with C5AR1 and Cardiovascular Diseases
 Necrosis Antibodies  >7 publications with C5AR1 and Necrosis
 Kidney Diseases Antibodies  >6 publications with C5AR1 and Kidney Diseases
 Nervous System Diseases Antibodies  >6 publications with C5AR1 and Nervous System Diseases
 Eye Diseases Antibodies  >3 publications with C5AR1 and Eye Diseases
 Lung Injury Antibodies  >3 publications with C5AR1 and Lung Injury
 Atherosclerosis Antibodies  >3 publications with C5AR1 and Atherosclerosis
 Fibrosis Antibodies  >3 publications with C5AR1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >52 publications with C5AR1 and Blood
 Bone Marrow Antibodies  >6 publications with C5AR1 and Bone Marrow
 Intestine Antibodies  >4 publications with C5AR1 and Intestine
 Brain Antibodies  >4 publications with C5AR1 and Brain
 Placenta Antibodies  >3 publications with C5AR1 and Placenta
 Uterus Antibodies  >1 publications with C5AR1 and Uterus
 Prostate Antibodies  >1 publications with C5AR1 and Prostate
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