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anti-CBLB antibody :: Mouse CBLB Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2527223
Western Blot (WB)
Unit / Price
0.06 mL  /  $220 +1 FREE 8GB USB
0.12 mL  /  $290 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CBLB, Monoclonal Antibody

 Also Known As   

CBLB Monoclonal Antibody

 Product Synonym Names    AI429560; AI851073; Cas Br M (murine) ecotropic retroviral transforming sequence b; Casitas B lineage lymphoma b; Casitas B lineage lymphoma proto oncogene b; Casitas B-lineage lymphoma proto-oncogene b; Cbl b; CBLB; CBLB; DKFZp686J10223; DKFZp779A0729; DKFZp779F1443; E3 ubiquitin protein ligase CBL B; E3 ubiquitin-protein ligase CBL-B; EC 6.3.2.-; FLJ36865; FLJ41152; Nbla00127; RING finger protein 56; RNF56; SH3 binding protein CBL B; SH3-binding protein CBL-B; Signal transduction protein CBL B; Signal transduction protein CBL-B
 Product Gene Name   

anti-CBLB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    More" target="_blank" rel="nofollow">604491 gene
 3D Structure    ModBase 3D Structure for Q13191
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 Clonality    Monoclonal
 Isotype    IgG3
 Clone Number    2D3A2
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Protein A purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    Fusion protein of CBLB
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, PH7.3
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CBLB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CBLB antibody

   CBLB(E3 ubiquitin-protein ligase CBL-B) is also known as RNF56 and plays a necessary role to prevent the inappropriate activation of NF-B in response to lipopolysaccharide and to polymicrobial sepsis. CBLB can be phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation. It also has a crucial role in the prevention of chronic inflammation and autoimmunity. This protein has 3 isoforms produced by alternative splicing.
 Product Categories/Family for anti-CBLB antibody    Cancer; Cell Biology; Immunology
 Applications Tested/Suitable for anti-CBLB antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-CBLB antibody    WB: 1:500-1:5000
IHC: 1:100-1:400
IF: 1:50-1:500
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 Western Blot (WB) of anti-CBLB antibody    Western Blot analysis of RAW 264.7 cells using CBLB Monoclonal Antibody at dilution of 1:1000
anti-CBLB antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CBLB. It may not necessarily be applicable to this product.
 NCBI GI #    1012443564
 NCBI GeneID    868
 NCBI Accession #    NP_001308717.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001321788.1 [Other Products]
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 UniProt Primary Accession #    Q13191 [Other Products]
 UniProt Secondary Accession #    Q13192; Q13193; Q3LIC0; Q63Z43; Q8IVC5; A8K9S7; B7WNM4 [Other Products]
 UniProt Related Accession #    Q13191 [Other Products]
 Molecular Weight    Calculated: 109kDa
Observed: 110kDa
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 NCBI Official Full Name    E3 ubiquitin-protein ligase CBL-B isoform b
 NCBI Official Synonym Full Names    Cbl proto-oncogene B
 NCBI Official Symbol    CBLB [Similar Products]
 NCBI Official Synonym Symbols   
Cbl-b; RNF56; Nbla00127
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase CBL-B
 UniProt Protein Name    E3 ubiquitin-protein ligase CBL-B
 UniProt Synonym Protein Names   
Casitas B-lineage lymphoma proto-oncogene b; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-BCurated; SH3-binding protein CBL-B; Signal transduction protein CBL-B
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    CBLB [Similar Products]
 UniProt Synonym Gene Names    RNF56 [Similar Products]
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 NCBI Summary for CBLB    This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
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 UniProt Comments for CBLB    E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
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 Research Articles on CBLB    1. miR-891b regulated the Smad3/ p21 axis by directly targeting the Cbl-b gene to inhibit the proliferative ability of pancreatic adenocarcinoma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CBLB antibodyPathways associated with anti-CBLB antibody
 Reference Product  PubMed Publications
 EGFR antibody  >17 publications with CBLB and EGFR
 SYK antibody  >15 publications with CBLB and SYK
 VAV1 antibody  >9 publications with CBLB and VAV1
 GRB2 antibody  >4 publications with CBLB and GRB2
 SH3KBP1 antibody  >4 publications with CBLB and SH3KBP1
 CRKL antibody  >2 publications with CBLB and CRKL
 UBC antibody  >1 publications with CBLB and UBC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-CBLB antibodyOrgans/Tissues associated with anti-CBLB antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >23 publications with CBLB and Nervous System Diseases
 Inflammation Antibodies  >16 publications with CBLB and Inflammation
 Neoplasms, Experimental Antibodies  >9 publications with CBLB and Neoplasms, Experimental
 Atrophy Antibodies  >8 publications with CBLB and Atrophy
 Necrosis Antibodies  >7 publications with CBLB and Necrosis
 Multiple Sclerosis Antibodies  >7 publications with CBLB and Multiple Sclerosis
 Lung Diseases Antibodies  >6 publications with CBLB and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with CBLB and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >4 publications with CBLB and Kidney Diseases
 Adenocarcinoma Antibodies  >4 publications with CBLB and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >114 publications with CBLB and Blood
 Bone Antibodies  >18 publications with CBLB and Bone
 Liver Antibodies  >15 publications with CBLB and Liver
 Muscle Antibodies  >13 publications with CBLB and Muscle
 Stomach Antibodies  >12 publications with CBLB and Stomach
 Lymph Node Antibodies  >10 publications with CBLB and Lymph Node
 Lung Antibodies  >9 publications with CBLB and Lung
 Bone Marrow Antibodies  >9 publications with CBLB and Bone Marrow
 Lymph Antibodies  >9 publications with CBLB and Lymph
 Kidney Antibodies  >8 publications with CBLB and Kidney
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