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anti-CCL-23 antibody :: Mouse anti-Human CCL-23 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690244 anti-CCL-23 antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCL-23, Monoclonal Antibody

 Also Known As   

Mouse Anti-Human CCL-23

 Product Synonym Names    CCL23; CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; CK-BETA-8
 Product Gene Name   

anti-CCL-23 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.11 (36013056..36018008, complement). Location: 17q12
 OMIM    602494
 3D Structure    ModBase 3D Structure for P55773
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    (12G21)
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CCL-23 (also called MPIF-1).
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CCL-23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CCL-23 antibody

   CCL23, also known as Myeloid Progenitor Inhibitory Factor1 (MPIF1), is a CC chemokine that is produced by some myeloid cell lines and monocytederived dendritic cells. It binds CCR1 and inhibits the differentiation of progenitor cells that give rise to granulocytes and macrophages. CCL23 is also chemotactic for resting T cells, neutrophils, monocytes and dendritic cells.
 Applications Tested/Suitable for anti-CCL-23 antibody   

Western Blot (WB), Neutr

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NCBI/Uniprot data below describe general gene information for CCL-23. It may not necessarily be applicable to this product.
 NCBI GI #    22538806
 NCBI GeneID    6368
 NCBI Accession #    NP_005055.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005064.4 [Other Products]
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 UniProt Primary Accession #    P55773 [Other Products]
 UniProt Secondary Accession #    O00174; O75950; Q52LD4; B7ZKQ3 [Other Products]
 UniProt Related Accession #    P55773 [Other Products]
 Molecular Weight    13,411 Da
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 NCBI Official Full Name    C-C motif chemokine 23 isoform CKbeta8-1
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 23
 NCBI Official Symbol    CCL23 [Similar Products]
 NCBI Official Synonym Symbols   
CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 23; C6 beta-chemokine; macrophage inflammatory protein 3; myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23
 UniProt Protein Name    C-C motif chemokine 23
 UniProt Synonym Protein Names   
CK-beta-8; CKB-8; Macrophage inflammatory protein 3; MIP-3; Myeloid progenitor inhibitory factor 1; MPIF-1; Small-inducible cytokine A23
 UniProt Gene Name    CCL23 [Similar Products]
 UniProt Synonym Gene Names    MIP3; MPIF1; SCYA23; CKB-8; MIP-3; MPIF-1 [Similar Products]
 UniProt Entry Name    CCL23_HUMAN
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 NCBI Summary for CCL-23    This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
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 UniProt Comments for CCL-23    Function: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Ref.9

Subcellular location: Secreted.

Tissue specificity: High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. Ref.9

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
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 Research Articles on CCL-23    1. Data show CCL23 stimulates chemotaxis of human THP-1 monocytes and enhances release of MMP-2, and suggest it plays a role in atherogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCL-23 antibodyPathways associated with anti-CCL-23 antibody
 Reference Product  PubMed Publications
 CCR1 antibody  >17 publications with CCL-23 and CCR1
 CCR2 antibody  >5 publications with CCL-23 and CCR2
 CCR3 antibody  >4 publications with CCL-23 and CCR3
 CXCR4 antibody  >3 publications with CCL-23 and CXCR4
 CCR5 antibody  >3 publications with CCL-23 and CCR5
 CX3CR1 antibody  >2 publications with CCL-23 and CX3CR1
 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies  Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-CCL-23 antibodyOrgans/Tissues associated with anti-CCL-23 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >7 publications with CCL-23 and Carcinoma
 Cardiovascular Diseases Antibodies  >3 publications with CCL-23 and Cardiovascular Diseases
 Leukemia, Myeloid, Acute Antibodies  >3 publications with CCL-23 and Leukemia, Myeloid, Acute
 Retinoblastoma Antibodies  >2 publications with CCL-23 and Retinoblastoma
 Obstetric Labor, Premature Antibodies  >2 publications with CCL-23 and Obstetric Labor, Premature
 Premature Birth Antibodies  >2 publications with CCL-23 and Premature Birth
 Fetal Resorption Antibodies  >1 publications with CCL-23 and Fetal Resorption
 Bone Neoplasms Antibodies  >1 publications with CCL-23 and Bone Neoplasms
 Fatty Liver Antibodies  >1 publications with CCL-23 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >2 publications with CCL-23 and Placenta
 Liver Antibodies  >2 publications with CCL-23 and Liver
 Lung Antibodies  >1 publications with CCL-23 and Lung
 Uncharacterized Tissue Antibodies  >1 publications with CCL-23 and Uncharacterized Tissue
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