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anti-CCNE1 antibody :: Mouse anti-Human CCNE1/Cyclin-E1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2543506 anti-CCNE1 antibody
Unit / Price
0.06 mL  /  $215 +1 FREE 8GB USB
0.12 mL  /  $330 +1 FREE 8GB USB
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCNE1/Cyclin-E1, Monoclonal Antibody

 Also Known As   

Mouse anti Human CCNE1/Cyclin-E1 Monoclonal Antibody

 Product Gene Name   

anti-CCNE1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M74093 mRNA
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human
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 Immunogen    Recombinant Human CCNE1/Cyclin-E1 protein
 Buffer    0.2 mum filtered solution in PBS with 5% trehalose
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 Preparation and Storage    This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CCNE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CCNE1 antibody   

Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-CCNE1 antibody    ICC/IF: 10-25 mug/mL
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NCBI/Uniprot data below describe general gene information for CCNE1. It may not necessarily be applicable to this product.
 NCBI GI #    333411298
 NCBI GeneID    898
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 UniProt Secondary Accession #    Q14091; Q8NFG1; Q92501; Q9UD21; A8K684 [Other Products]
 UniProt Related Accession #    P24864 [Other Products]
 Molecular Weight    45,150 Da
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 NCBI Official Full Name    cyclin E1, partial
 NCBI Official Synonym Full Names    cyclin E1
 NCBI Official Symbol    CCNE1 [Similar Products]
 NCBI Official Synonym Symbols   
CCNE; pCCNE1
[Similar Products]
 NCBI Protein Information    G1/S-specific cyclin-E1
 UniProt Protein Name    G1/S-specific cyclin-E1
 UniProt Gene Name    CCNE1 [Similar Products]
 UniProt Synonym Gene Names    CCNE [Similar Products]
 UniProt Entry Name    CCNE1_HUMAN
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 NCBI Summary for CCNE1    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
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 UniProt Comments for CCNE1    CCNE1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described.

Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 19q12

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; protein amino acid phosphorylation
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 Research Articles on CCNE1    1. These results indicate that miR-25 has anti-apoptosis roles in AGS cells, possibly via inhibiting FBXW7 and thus promoting oncogenes, such as CCNE1 and MYC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCNE1 antibodyPathways associated with anti-CCNE1 antibody
 Reference Product  PubMed Publications
 CDK2 antibody  >105 publications with CCNE1 and CDK2
 CDKN1A antibody  >44 publications with CCNE1 and CDKN1A
 CDKN1B antibody  >39 publications with CCNE1 and CDKN1B
 FBXW7 antibody  >19 publications with CCNE1 and FBXW7
 RB1 antibody  >18 publications with CCNE1 and RB1
 CDK1 antibody  >14 publications with CCNE1 and CDK1
 CDC25A antibody  >9 publications with CCNE1 and CDC25A
 E2F3 antibody  >4 publications with CCNE1 and E2F3
 Products by Pathway  Pathway Diagram
 ATM Signaling Pathway antibodies  ATM Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-CCNE1 antibodyOrgans/Tissues associated with anti-CCNE1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >74 publications with CCNE1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >73 publications with CCNE1 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >48 publications with CCNE1 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >29 publications with CCNE1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >27 publications with CCNE1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >27 publications with CCNE1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >26 publications with CCNE1 and Liver Diseases
 Disease Progression Antibodies  >25 publications with CCNE1 and Disease Progression
 Lung Neoplasms Antibodies  >21 publications with CCNE1 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >20 publications with CCNE1 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >43 publications with CCNE1 and Liver
 Lung Antibodies  >32 publications with CCNE1 and Lung
 Kidney Antibodies  >13 publications with CCNE1 and Kidney
 Ovary Antibodies  >12 publications with CCNE1 and Ovary
 Skin Antibodies  >10 publications with CCNE1 and Skin
 Prostate Antibodies  >10 publications with CCNE1 and Prostate
 Intestine Antibodies  >7 publications with CCNE1 and Intestine
 Embryonic Tissue Antibodies  >5 publications with CCNE1 and Embryonic Tissue
 Placenta Antibodies  >5 publications with CCNE1 and Placenta
 Eye Antibodies  >4 publications with CCNE1 and Eye
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